“…RNA-Seq analyses showed that the gain of LOC339059 repressed the expression of the interleukin family, especially IL-6/STAT3 signaling. The rescue of IL-6 in LOC339059-overexpressing cells reverted the inhibitory effects of the gain of LOC339059 on malignant cell phenotypes. …”
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“…However, the burden of invasive pneumococcal disease (IPD) remains poorly described, especially among older adults. We evaluated the incidence, demographics, clinical characteristics, and outcomes among older adults hospitalized with IPD in São Paulo (SP), the largest city in Brazil. …”
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“…The rise of the FLC-R and AMB-R phenotypes is worrying, especially in NA. MGX and ECH remained active against CAU regardless of the resistant phenotype or study period. …”
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“…[Figure: see text] [Figure: see text] CONCLUSION: Donor-derived Candida infections occur with significant associated morbidity, including graft loss, and mortality, especially in kidney recipients. Opportunity exists to further identify risks, improve communication across transplant centers, initiate appropriate antifungal therapy, and improve management of mycotic aneurysm due to candidiasis. …”
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“…Septic subjects had lower ex vivo PHA-induced cytokine production (Fig4), and relative lymphopenia by flow cytometry vs healthy controls, especially double negative-T cells (3.7% vs 8.4%; p=0.03) and γδ-T cells (2.9% vs 7.6%; p=0.03). 12 septic subjects had IP. …”
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“…Less than half of IDP have received a bivalent booster. Additional doses, especially the bivalent dose, enhances the immune response in this population. …”
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“…CONCLUSION: Although variable, there are still concerning misbeliefs surrounding antibiotic use for the management of respiratory illnesses, especially in the younger population. Different channels of communication may be required to increase health literacy on the appropriate use of antibiotics in the younger population. …”
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“…ICS confirmed significant regimen-dependent SNMO-specific increases in IFNγ, IL-2 and TNFα response especially in the CD4(+) T cell subset, including induction of polyfunctional CD4(+) T cells. …”
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“…BACKGROUND: Children and adults have had different experiences during the COVID-19 pandemic, especially in the context of new SARS-CoV-2 variants and changing vaccine eligibility. …”
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“…Dual assessment and management of insulin resistance and blood pressure contribute to the prevention of CVD, especially in younger individuals. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12933-023-02058-1.…”
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“…Several recent studies have shown the relationship between the TyG index and cardiovascular outcomes; however, the role of the TyG index in chronic coronary syndrome (CCS) progression has not been extensively assessed especially in population after revascularization. This study aimed to investigate the prognostic value of the TyG index in predicting MACEs in CCS patients undergoing percutaneous coronary intervention (PCI). …”
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“…BACKGROUND: Digital technologies, especially contact tracing apps, have been crucial in monitoring and tracing the transmission of COVID-19 worldwide. …”
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“…THZ1 significantly suppressed the phosphorylation of RNAPOLII, and this effect was stronger in KRAS‐G12V PDAC (especially at ser5). KRAS‐G12V PDAC had more H3K27ac‐binding super‐enhancers, and the inhibition of THZ1 on super‐enhancer activity was also stronger in KRAS‐G12V PDAC. …”
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“…Screening programs and early ID diagnostics are crucial for the follow-up of pregnant women, especially in iodine-deficient nations. There have been calls for universal salt iodization programs, but only approximately 71% of people have access to them. …”
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“…(iv) The observed advantages and disadvantages were varied and could not be compared, especially for the offspring of APA parents. LIMITATIONS, REASONS FOR CAUTION: Only English-language studies, published between 2000 and 2021, found in the above-mentioned databases were considered for this review. …”
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“…Therefore, physical exercises and mindfulness training may be recommended to improve interoception, especially in women and people suffering from somatic and mental problems. …”
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“…Collectively the neural outcomes of impaired astrocytic release of lactate manifest behaviourally as inefficient and inconsistent performance (variable response times across the lifespan, especially during activities that require sustained speeded responses and complex information processing). …”
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“…CONCLUSIONS: Our data suggest that a large proportion of the US men had suboptimal vitamin D status (especially during the winter/spring season), and both 25(OH)D and 1,25(OH)(2)D may play an important role in preventing prostate cancer progression. …”
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“…CONCLUSIONS: The three polymorphisms associated with increased EGFR protein production (shorter CA-SSR1 length and variant forms of SNPs −216 and −191) were found to be rare in East Asians as compared to other ethnicities, suggesting that the cells of East Asians may make relatively less intrinsic EGFR protein. Interestingly, especially in tumors from patients of East Asian ethnicity, EGFR mutations were found to favor the shorter allele of CA-SSR1, and selective amplification of the shorter allele of CA-SSR1 occurred frequently in tumors harboring a mutation. …”
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“…In addition to the results brought out in the separate sections I wish to direct especial attention to the following conclusions: (1) In ten cases of Cheyne-Stokes respiration observed clinically, the alternate periods of respiratory activity and apnœa were associated with Traube-Hering waves of blood pressure. …”
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