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  1. 277561
    “…Inclusion of subjects and data-analyses is ongoing, and data analysis will be more extensive in spring 2018, especially regarding the methodology: The current image derived input function suffers from partial volume effects (PVE). …”
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    S150. DOPAMINE SYNTHESIS CAPACITY IN ANTIPSYCHOTIC NAïVE FIRST EPISODE PSYCHOTIC PATIENTS
  2. 277562
    “…The metabolic changes in people with first-episode psychosis (FEP) taking place after the onset of psychosis can be especially harmful as these individuals are typically young and without major somatic illnesses. …”
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    F166. LOW-GRADE INFLAMMATION IN FIRST-EPISODE PSYCHOSIS IS DETERMINED BY WAIST CIRCUMFERENCE INCREASE
  3. 277563
    “…The results also suggest that baseline neuroanatomical measures are likely to be useful in prediction of psychosis especially (or only) among CHR cases who are below 18 years of age at the time of ascertainment.…”
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    S184. MACHINE LEARNING REVEALS DEVIANCE IN NEUROANATOMICAL MATURITY PREDICTIVE OF FUTURE PSYCHOSIS IN YOUTH AT CLINICAL HIGH RISK
  4. 277564
    “…This relationship was especially pronounced for the syndrome of Reality Distortion (rho = -.344, p < 0.05) and Disorganization (rho = -.303, p = 0.065), where higher symptom severity was seen in patients with lower mean GS. …”
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    T143. NOT A NUISANCE ANY MORE: GLOBAL FMRI SIGNAL AT REST, PROCESSING SPEED AND SYMPTOM SEVERITY IN SCHIZOPHRENIA
  5. 277565
    “…BACKGROUND: It is common knowledge that antipsychotic treatment improves the symptomatology in schizophrenia, especially for the psychotic and general symptoms. It is also a fact that patients with schizophrenia often report a reduced quality of life compared to healthy controls. …”
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    S250. RELATION BETWEEN PSYCHOPATHOLOGY AND QUALITY OF LIFE IN SCHIZOPHRENIA PATIENTS BEFORE AND AFTER FIRST ANTIPSYCHOTIC TREATMENT
  6. 277566
    “…Earlier studies have shown that PEs during childhood are predictive of later psychotic disorders, especially if they persist over time. We expect the possible risk factors to have a cumulative effect. …”
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    S34. DEVELOPMENTAL TRAJECTORIES OF PSYCHOTIC EXPERIENCES AND THEORY OF MIND IN 11-YEAR-OLD OFFSPRING OF PARENTS WITH SCHIZOPHRENIA OR BIPOLAR DISORDER
  7. 277567
    por Rivas, Manuel A., Avila, Brandon E., Koskela, Jukka, Huang, Hailiang, Stevens, Christine, Pirinen, Matti, Haritunians, Talin, Neale, Benjamin M., Kurki, Mitja, Ganna, Andrea, Graham, Daniel, Glaser, Benjamin, Peter, Inga, Atzmon, Gil, Barzilai, Nir, Levine, Adam P., Schiff, Elena, Pontikos, Nikolas, Weisburd, Ben, Lek, Monkol, Karczewski, Konrad J., Bloom, Jonathan, Minikel, Eric V., Petersen, Britt-Sabina, Beaugerie, Laurent, Seksik, Philippe, Cosnes, Jacques, Schreiber, Stefan, Bokemeyer, Bernd, Bethge, Johannes, Heap, Graham, Ahmad, Tariq, Plagnol, Vincent, Segal, Anthony W., Targan, Stephan, Turner, Dan, Saavalainen, Paivi, Farkkila, Martti, Kontula, Kimmo, Palotie, Aarno, Brant, Steven R., Duerr, Richard H., Silverberg, Mark S., Rioux, John D., Weersma, Rinse K., Franke, Andre, Jostins, Luke, Anderson, Carl A., Barrett, Jeffrey C., MacArthur, Daniel G., Jalas, Chaim, Sokol, Harry, Xavier, Ramnik J., Pulver, Ann, Cho, Judy H., McGovern, Dermot P. B., Daly, Mark J.
    Publicado 2018
    “…As validation we document 148 AJ enriched protein-altering alleles that overlap with "pathogenic" ClinVar alleles (table available at https://github.com/macarthur-lab/clinvar/blob/master/output/clinvar.tsv), including those that account for 10–100 fold differences in prevalence between AJ and non-AJ populations of some rare diseases, especially recessive conditions, including Gaucher disease (GBA, p.Asn409Ser, 8-fold enrichment); Canavan disease (ASPA, p.Glu285Ala, 12-fold enrichment); and Tay-Sachs disease (HEXA, c.1421+1G>C, 27-fold enrichment; p.Tyr427IlefsTer5, 12-fold enrichment). …”
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    Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population
  8. 277568
    “…CONCLUSIONS: Less educated and nonwhite patients using the portal each assigned higher importance to reading notes for several health behaviors than highly educated and white patients, and may find transparent notes especially valuable for understanding their health and engaging in their care. …”
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    The Importance of Visit Notes on Patient Portals for Engaging Less Educated or Nonwhite Patients: Survey Study
  9. 277569
    Publicado 2013
    “…Surgery can prolong OS of patients with stage Ⅲa, especially for stage T4N0/T3-4N1M0. However, it has no benefit on PFS. …”
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    Ⅲ期非小细胞肺癌手术是否有价值
  10. 277570
    “…Past interventions have had only limited success in effectively managing pregnancy weight gain, especially among women with overweight and obesity. …”
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    Individually Tailored, Adaptive Intervention to Manage Gestational Weight Gain: Protocol for a Randomized Controlled Trial in Women With Overweight and Obesity
  11. 277571
    “…Our findings conclude that myelotomy promotes locomotor recovery in rats with spinal cord injury, especially in those with moderate injury.…”
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    Myelotomy promotes locomotor recovery in rats subjected to spinal cord injury: a meta-analysis of six randomized controlled trials
  12. 277572
    “…However, rigorous research on the impact of EHR systems on behavioral health service delivery is scant, especially for children and adolescents. OBJECTIVE: The current study evaluated the usability of an EHR developed to support the implementation of the Wraparound care coordination model for children and youth with complex behavioral health needs, and impact of the EHR on service processes, fidelity, and proximal outcomes. …”
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    Impact of a Web-Based Electronic Health Record on Behavioral Health Service Delivery for Children and Adolescents: Randomized Controlled Trial
  13. 277573
    “…BACKGROUND: Phospholipids in the central nervous system are enriched in n-3 and n-6 polyunsaturated fatty acids (PUFA), especially docosahexaenoic acid (DHA) and arachidonic acid (ARA). …”
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    Unveiling anti-oxidative and anti-inflammatory effects of docosahexaenoic acid and its lipid peroxidation product on lipopolysaccharide-stimulated BV-2 microglial cells
  14. 277574
    “…In the men exposed to agalsidase, inhibition was correlated with the total IgG titer (r = 0.67, p < 0.0001), especially IgG4 (r = 0.75, p = 0.0005) and IgG2 (r = 0.72, p = 0.001). …”
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    Deep characterization of the anti-drug antibodies developed in Fabry disease patients, a prospective analysis from the French multicenter cohort FFABRY
  15. 277575
    por Jankowski, Janusz A Z, de Caestecker, John, Love, Sharon B, Reilly, Gavin, Watson, Peter, Sanders, Scott, Ang, Yeng, Morris, Danielle, Bhandari, Pradeep, Attwood, Stephen, Ragunath, Krish, Rameh, Bashir, Fullarton, Grant, Tucker, Art, Penman, Ian, Rodgers, Colin, Neale, James, Brooks, Claire, Wise, Adelyn, Jones, Stephen, Church, Nicholas, Gibbons, Michael, Johnston, David, Vaidya, Kishor, Anderson, Mark, Balata, Sherzad, Davies, Gareth, Dickey, William, Goddard, Andrew, Edwards, Cathryn, Gore, Stephen, Haigh, Chris, Harding, Timothy, Isaacs, Peter, Jackson, Lucina, Lee, Thomas, Lim, Peik Loon, Macdonald, Christopher, Mairs, Philip, McLoughlin, James, Monk, David, Murdock, Andrew, Murray, Iain, Preston, Sean, Pugh, Stirling, Smart, Howard, Soliman, Ashraf, Todd, John, Turner, Graham, Worthingon, Joy, Harrison, Rebecca, Barr, Hugh, Moayyedi, Paul
    Publicado 2018
    “…INTERPRETATION: High-dose PPI and aspirin chemoprevention therapy, especially in combination, significantly and safely improved outcomes in patients with Barrett's oesophagus. …”
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    Esomeprazole and aspirin in Barrett's oesophagus (AspECT): a randomised factorial trial
  16. 277576
    “…CONCLUSION: Patient selection had been changed between the first 100 and the last 100 cohorts. Higher age, especially older 46 year-old, was significantly associated with higher conversion rate to THR. …”
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    My First 100 Compared to My Last 100 Labral Reconstructions- The Role of Patient Selection in Increasing Survivorship
  17. 277577
    “…CONCLUSION: In this prospective study, (18)F-fluorocholine PET/CT showed promise as a functional imaging modality, being clearly superior to (99m)Tc-MIBI/tetrofosmin SPECT/CT, especially in the detection and localization of small parathyroid adenomas in patients with primary hyperparathyroidism. …”
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    (18)F-Fluorocholine PET/CT in the assessment of primary hyperparathyroidism compared with (99m)Tc-MIBI or (99m)Tc-tetrofosmin SPECT/CT: a prospective dual-centre study in 100 patients
  18. 277578
    “…OBJECTIVES: Recent literature has suggested residual quadriceps weakness up to 12 months after anterior cruciate ligament reconstruction (ACLR), especially with quadriceps tendon autograft. These studies, though, have not directly compared different autograft options. …”
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    Comparison of Short-Term Biodex Results after Anatomic ACL Reconstruction Between Three Autografts
  19. 277579
    “…The shortest needles (currently the 4-mm pen and 6-mm syringe needles) are safe, effective, and less painful and should be the first-line choice in all patient categories; intramuscular (IM) injections should be avoided, especially with long-acting insulins, because severe hypoglycemia may result; lipohypertrophy is a frequent complication of therapy that distorts insulin absorption, and therefore, injections and infusions should not be given into these lesions and correct site rotation will help prevent them (A). …”
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    EADSG Guidelines: Insulin Therapy in Diabetes
  20. 277580
    “…Previous studies have established that milk fat globule-EGF factor-8 (MFG-E8) provides neuroprotection through modulation of inflammation, oxidative stress, and especially apoptosis in cerebral ischemia and neurodegenerative disease. …”
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    Recombinant milk fat globule-EGF factor-8 reduces apoptosis via integrin β3/FAK/PI3K/AKT signaling pathway in rats after traumatic brain injury
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