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  1. 277901
    “…Real‐world patients are more diverse than clinical trials, and clinicians should consider both the efficacy and safety profile of ICI treatments, especially for patients with comorbidity conditions. …”
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    Online Artículo Texto
    Real‐World Clinical and Economic Outcomes in Selected Immune‐Related Adverse Events Among Patients with Cancer Receiving Immune Checkpoint Inhibitors
  2. 277902
    “…CONCLUSIONS: The incidence of DVT for COVID-19 patients receiving standard-dose prophylactic anticoagulation that was not weight adjusted was high, especially for ICU patients. DVT is one of the factors contributing to increased mortality. …”
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    Incidence and effects of deep vein thrombosis on the outcome of patients with coronavirus disease 2019 infection
  3. 277903
    “…ABSTRACT: Background: The major limitation of piecemeal endoscopic mucosal resection (EMR) is the inaccurate histological assessment of the resected specimen, especially in cases of submucosal invasion. Objective: To classify non-pedunculated lesions ≥20 mm based on endoscopic morphological features, in order to identify those that present intramucosal neoplasia (includes low-grade neoplasia and high-grade neoplasia) and are suitable for piecemeal EMR. …”
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    Compound Endoscopic Morphological Features for Identifying Non-Pedunculated Lesions ≥20 mm with Intramucosal Neoplasia
  4. 277904
    “…Children with PSD are also more likely to be identified as having SEN in secondary school, especially communication and interaction needs but also including cognition and learning needs. …”
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    Educational outcomes associated with persistent speech disorder
  5. 277905
    “…BACKGROUND: The physiology of sheep as small ruminants is remarkably different from monogastric animals especially regarding the forestomach system. Using sheep for surgical procedures during scientific research thereby presents an exceptional setting for the anaesthetist. …”
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    Online Artículo Texto
    Analysis of pH and electrolytes in blood and ruminal fluid, including kidney function tests, in sheep undergoing long-term surgical procedures
  6. 277906
    “…The pCR rate also increased in both PD-L1 positive (OR: 1.65; 95% CI: 1.26–2.16, P < 0.001) and PD-L1 negative patients (OR: 1.56; 95% CI: 1.04–2.33, P = 0.03), especially in PD-L1 positive patients. The benefit was also observed in nodal-positive populations (OR: 2.52; 95% CI: 1.69–3.77, P < 0.001) and Eastern Cooperative Oncology Group performance-status score (ECOG PS) 0 subgroup (OR: 1.90; 95% CI: 1.42–2.53, P < 0.001). …”
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    Immune checkpoint inhibitors plus neoadjuvant chemotherapy in early triple-negative breast cancer: a systematic review and meta-analysis
  7. 277907
    “…CONCLUSIONS: Disability increases the risk of all-cause death in the elderly, especially those with chronic diseases and the young-old group. …”
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    Online Artículo Texto
    Disability and the risk of subsequent mortality in elderly: a 12-year longitudinal population-based study
  8. 277908
    “…Such support should be considered especially for patients with low HRQoL, low exercise motivation, high exercise expectations or with a history of tobacco use at the start of their cancer treatment, as well as for those gaining weight during their treatment. …”
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    Effect of self-regulatory behaviour change techniques and predictors of physical activity maintenance in cancer survivors: a 12-month follow-up of the Phys-Can RCT
  9. 277909
    “…Our results suggest a key role for usual clinicians, especially primary care clinicians, in vaccination uptake for this population.…”
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    National Trends and Outcomes Associated With Presence and Type of Usual Clinician Among Older Adults With Multimorbidity
  10. 277910
    “…RESULT: Here, we identify a human-specific long non-coding RNA (lncRNA, ENST00000595422), termed PKMYT1AR (PKMYT1 associated lncRNA), that is induced in NSCLC by Yin Yang 1 (YY1) factor, especially in cancerous cell lines (H358, H1975, H1299, H1650, A549 and SPC-A1) compared to that in normal human bronchial epithelium cell line (BEAS-2B). …”
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    LncRNA PKMYT1AR promotes cancer stem cell maintenance in non-small cell lung cancer via activating Wnt signaling pathway
  11. 277911
    “…Adolescent-friendly strategies to improve VL suppression e.g. peer involvement, VL focal persons to identify and actively follow-up non-suppressed adolescents, patient education on VL suppression and demand creation for ART are needed, especially for newly-initiated adolescents and adolescents on ART for protracted periods, to foster attainment of the UNAIDS 95–95–95 targets.…”
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    Determinants of viral load non-suppression among adolescents in Mbale District, Eastern Rural Uganda
  12. 277912
    “…Antibiotic treatment was common (%%) especially in neonates (40.9%), despite bacterial coinfection was rare (8.7%), length of hospitalization was longer in older than 2-year-old groups. 23(1.9%) patients died, similar across different age groups. …”
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    1189. COVID 19 Infection in Children in Colombia, Experience from a Nationwide Network (CORONARED)
  13. 277913
    “…With the safe and reliable self-collection of saliva, our vision is to help provide accessible and equitable testing solutions, especially in low-resource and remote settings. DISCLOSURES: Anne Wyllie, PhD, Global Diagnostic Systems (Consultant)Pfizer (Advisor or Review Panel member, Research Grant or Support)PPS Health (Consultant)Tempus Labs, Inc (Research Grant or Support) Nathan D. …”
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    362. Saliva as a Reliable Sample Type for Mass SARS-CoV-2 Testing Strategies
  14. 277914
    “…Patients who underwent CBT had a higher procedure-related distal embolization rate and economic cost than those who underwent primary CDT (P < .05), but it had slightly fewer complications than those who underwent primary CDT (P = .059), especially minor complications (P = .036). The freedom from amputation at 6 and 12 months for CBT and CDT was assessed (93.0% vs 90.2% respectively, P = .625; 89.5% vs 82.9%, respectively, P = .34,). …”
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    Endovascular revascularization strategies using catheter-based thrombectomy versus conventional catheter-directed thrombolysis for acute limb ischemia
  15. 277915
    “…The Oswestry disability index of group 1 were significantly better than those in group 2 especially at 1 month and final follow‐up after surgery (P < 0.05). …”
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    The Clinical Effect of Manual Reduction Combined with Internal Fixation Through Wiltse Paraspinal Approach in the Treatment of Thoracolumbar Fracture
  16. 277916
    “…However, the prevalence of substance use and SUDs in AN has not been studied in-depth, especially the differences in the prevalence of SUDs between AN types [e.g., AN-R (restrictive type) and AN-BP (binge-eating/purge type]. …”
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    Online Artículo Texto
    The prevalence of substance use disorders and substance use in anorexia nervosa: a systematic review and meta-analysis
  17. 277917
    “…Family history showed a correlation with both BRCA (p = 0.005) and non-BRCA HRR gene mutation status (p = 0.036), so we strongly suggest that breast cancer patients with a BRCA-related family history receive comprehensive gene mutation testing in China, especially HRR genes, which are not only related to high risk of breast cancer, but also potentially related to poly ADP ribose polymerase inhibitor (PARPi) targeted therapy. …”
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    Characteristics of Germline Non-BRCA Mutation Status of High-Risk Breast Cancer Patients in China and Correlation with High-Risk Factors and Multigene Testing Suggestions
  18. 277918
    “…BACKGROUND: Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a rare disease, which is often underdiagnosed due to its heterogeneous presentations and complex molecular genetic basis, leading to a lack of population-based epidemiology data, especially of prevalence and disease progression. METHODS: Fujian Neuromedical Centre (FNMC) is a diagnosis centre for clinical-genetic FSHD in China, and the only one employing pulsed-field gel electrophoresis (PFGE)-based Southern blotting for all FSHD1 genetic tests. …”
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    Prevalence and disease progression of genetically-confirmed facioscapulohumeral muscular dystrophy type 1 (FSHD1) in China between 2001 and 2020: a nationwide population-based study
  19. 277919
    por Ahmed, Tahmeed, Chisti, Mohammod Jobayer, Rahman, Muhammad Waliur, Alam, Tahmina, Ahmed, Dilruba, Parvin, Irin, Kabir, Md. Farhad, Sazawal, Sunil, Dhingra, Pratibha, Dutta, Arup, Deb, Saikat, Chouhan, Aishwarya, Sharma, Anil Kumar, Jaiswal, Vijay Kumar, Dhingra, Usha, Walson, Judd L., Singa, Benson O., Pavlinac, Patricia B., McGrath, Christine J., Nyabinda, Churchil, Deichsel, Emily L., Anyango, Maurine, Kariuki, Kevin Mwangi, Rwigi, Doreen, Tornberg-Belanger, Stephanie N., Kotloff, Karen L., Sow, Samba O., Tapia, Milagritos D., Haidara, Fadima Cheick, Mehta, Ashka, Coulibaly, Flanon, Badji, Henry, Permala-Booth, Jasnehta, Tennant, Sharon M., Malle, Dramane, Bar-Zeev, Naor, Dube, Queen, Freyne, Bridget, Cunliffe, Nigel, Ndeketa, Latif, Witte, Desiree, Ndamala, Chifundo, Cornick, Jennifer, Qamar, Farah Naz, Yousafzai, Mohammad Tahir, Qureshi, Shahida, Shakoor, Sadia, Thobani, Rozina, Hotwani, Aneeta, Kabir, Furqan, Mohammed, Jan, Manji, Karim, Duggan, Christopher P., Kisenge, Rodrick, Sudfeld, Christopher R., Kibwana, Upendo, Somji, Sarah, Bakari, Mohamed, Msemwa, Cecylia, Samma, Abraham, Bahl, Rajiv, De Costa, Ayesha, Simon, Jonathon, Ashorn, Per
    Publicado 2021
    “…However, recent studies suggest that a significant proportion of such episodes have a bacterial cause and are associated with mortality and growth impairment, especially among children at high risk of diarrhea-associated mortality. …”
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    Effect of 3 Days of Oral Azithromycin on Young Children With Acute Diarrhea in Low-Resource Settings: A Randomized Clinical Trial
  20. 277920
    “…CONCLUSIONS: Both cost effectiveness and cost utility indicators are highly impacted by the prevalence and population, as well as the treatment schedules. Adults especially men in the areas with a prevalence over 10% should be prioritized, in which selective chemotherapy was best and massive chemotherapy was also cost effective. …”
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    Cost yield of different treatment strategies against Clonorchis sinensis infection
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