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61por Varea, Olga, Garrido, Juan Jose, Dopazo, Ana, Mendez, Pablo, Garcia-Segura, Luis Miguel, Wandosell, Francisco“…Estradiol may fulfill a plethora of functions in neurons, in which much of its activity is associated with its capacity to directly bind and dimerize estrogen receptors. …”
Publicado 2009
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62por Kuo, John, Hamid, Naheed, Bondar, Galyna, Dewing, Phoebe, Clarkson, Jenny, Micevych, Paul“…A crucial feature of this positive feedback is the ability of estradiol to facilitate progesterone synthesis in female hypothalamic astrocytes. …”
Publicado 2010
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64“…Estradiol has profound actions on the structure and function of the nervous system. …”
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65“…In parallel research, several steroids, including estradiol, were found to have rapid effects on neuronal excitability, partially explained by novel actions at neuronal membranes. …”
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66por Stein, Mark, Goodin, Susan, Doyle-Lindrud, Susan, Silberberg, Jeffrey, Kane, Michael, Metzger, Dorinda, Eddy, Simantini, Shih, Weichung, DiPaola, Robert S.“…BACKGROUND: Given prior studies demonstrating the marked clinical activity of oral estrogens in prostate cancer, more recent data demonstrating the safety of transdermal estradiol, and the renewed interest in targeting testosterone metabolism and androgen receptor pathways, we report the results of a trial of transdermal estradiol in advanced heavily pre-treated castrate and chemotherapy refractory patients. …”
Publicado 2012
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67por Labruijere, S, Verbiest, M, De Vries, R, Danser, AHJ, Uitterlinden, AG, Stolk, L, MaassenVanDenBrink, AEnlace del recurso
Publicado 2013
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68por Burke, Anne“…The oral contraceptive NOMAC-E2 contains nomegestrol acetate (NOMAC) 2.5 mg + 17b-estradiol (E2) 1.5 mg. The approved dosing regimen is 24 days of active hormone, followed by a 4-day hormone-free interval. …”
Publicado 2013
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71por Tam, Anthony, Wadsworth, Samuel, Dorscheid, Delbert, Man, Shu-Fan Paul, Sin, Don D.“…Protein microarray data showed that nuclear factor of activated T-cell (NFAT) in the nuclear fraction of NHBE cells was increased with estradiol treatment. Estradiol increased NFATc1 mRNA and protein in ALI cultures. …”
Publicado 2014
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72“…MATERIALS AND METHODS: Eighteen Wistar female rats (bodyweight, 200-250 g) were randomly divided into three groups. Group 1 received estradiol, Group 2 received ghrelin and Group 3 received ghrelin and estradiol. …”
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73“…RESULTS: Zearalenol—but not estradiol (E(2))- or ginseng-treated spermatozoa—decreased the percentage of overall, progressive, and rapid motile cells. …”
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74por Santos, Roberta S., de Fatima, Luciana A., Frank, Aaron P., Carneiro, Everardo M., Clegg, Deborah J.“…BACKGROUND: 17 Alpha-estradiol (17 α-E2) is a natural, non-feminizing stereoisomer of 17 beta-estradiol (17 β-E2). …”
Publicado 2017
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75por Sharifi, Mohammad Davood, Mohebbi, Masoud, Farrokhfar, Mahmood, Farzaneh, Roohie, Disfani, Hamideh Feiz, Hashemian, Amir Masoud“…On the basis of the serum estradiol level, patients’ percentages with low estradiol level in control and test groups were 10% and 16.7%, respectively (p=0.283). …”
Publicado 2018
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76“…Classically, estrogen status is thought to derive mainly from ovarian sources; however, it is well known that estradiol (E2) also is synthesized by neurons in the brain. …”
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77por Sasso, Corina Verónica, Santiano, Flavia Eliana, Campo Verde Arboccó, Fiorella, Zyla, Leila Esther, Semino, Silvana Noemí, Guerrero-Gimenez, Martin Eduardo, Pistone Creydt, Virginia, López Fontana, Constanza Matilde, Carón, Rubén Walter“…Thirty days later, the rats were ovariectomized and treated with estradiol (60 μg/kg), progesterone (10 mg/kg), estradiol plus progesterone (60 μg/kg and 10 mg/kg) or vehicle. …”
Publicado 2019
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78por Li, Guangrun, Jiang, Xiaofeng, Liu, Liping, Liu, Xiaoyang, Liu, Hongtao, Zhang, Zuofu“…Estradiol (E2) serves an important role in the changes of postmenopausal bone turnover rate and the development of osteoporosis. …”
Publicado 2019
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79por Simon, James A., Pickar, James H., Shadiack, Annette M., Warrier, Bharat, Graham, Shelli, Bernick, Brian, Mirkin, Sebastian“…OBJECTIVE: TX-004HR is a low-dose estradiol (E2) softgel vaginal insert designed to be rapidly dissolving and mucoadhesive. …”
Publicado 2019
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80“…The present study aimed to investigate the effects of estradiol (E2) on inflammatory and endothelial dysfunction in an N (omega)-nitro-L-arginine methyl ester (L-NAME)-induced rat model of PE. …”
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