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  1. 1
    “…We present five peripubertal girls (aged 12.5–14.9 years) with hypogonadism (two with primary hypogonadism due to Turner syndrome and three with central (secondary) hypogonadism as part of multiple pituitary hormone deficiency) who for a variety of reasons have received milligram doses of estradiol (E(2)) in error for between 6 weeks and 6 months, instead of the expected microgram doses of ethinyl estradiol. …”
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    Estradiol: micrograms or milligrams
  2. 2
    “…Estradiol (E2) regulates gene expression at the transcriptional level by functioning as a ligand for estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ). …”
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    Estradiol-regulated microRNAs control estradiol response in breast cancer cells
  3. 3
    “…For example, 15α-hydroxy-estradiol [15α-OH-E2] is the estrogen, instead of estradiol [E2]. …”
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    3D Model of Lamprey Estrogen Receptor with Estradiol and 15α-Hydroxy-Estradiol
  4. 4
    “…Natural estrogens such as estradiol (E(2)) or its valerate ester (E(2)V) offer an alternative to ethinyl estradiol (EE). …”
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    An overview of the development of combined oral contraceptives containing estradiol: focus on estradiol valerate/dienogest
  5. 5
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    The Bio-assay of β-Estradiol
  6. 6
    “…The responses to buserelin of estradiol, TSH and PRL were of wide magnitude. There was a significant correlation between TSH peak and serum estradiol peak, betweeen AUC0-24 h-TSH and AUC0-24 h-estradiol, or between PRL peak and estradiol peak and AUC0-24 h -PRL and AUC0-24 h-estradiol in only a subgroup of women. …”
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    Circulating thyrotropin is upregulated by estradiol
  7. 7
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    Estradiol and appetite: To eat or not to eat
  8. 8
    “…In this regard, hormonal balance and, in particular, estradiol, seems to be essential in skeletal muscle function. …”
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    Sarcopenia and Menopause: The Role of Estradiol
  9. 9
    “…Of the steroids tested, only 17β-estradiol and 17α-estradiol inhibited EROD and MROD activities. …”
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    In vitro inhibition of porcine cytochrome P450 by 17β -estradiol and 17α-estradiol
  10. 10
    “…OBJECTIVE: To evaluate the pharmacokinetics of TX-004HR vaginal estradiol softgel capsules when used for treating moderate-to-severe dyspareunia in postmenopausal women with vulvar and vaginal atrophy. …”
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    TX-004HR vaginal estradiol has negligible to very low systemic absorption of estradiol
  11. 11
    “…CONTEXT: Estradiol is the primary female sex hormone and plays an important role for skeletal health in both sexes. …”
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    Genome-wide Association Study of Estradiol Levels and the Causal Effect of Estradiol on Bone Mineral Density
  12. 12
    “…Estradiol is known as one of the most potent estrogenic endocrine-disrupting chemicals (EDCs) that may cause various health implications on human growth, metabolism regulation, the reproduction system, and possibly cancers. …”
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    Role of Estradiol Hormone in Human Life and Electrochemical Aptasensing of 17β-Estradiol: A Review
  13. 13
    “…Introduction: The purpose of the study is to compare the effects of genistein, estradiol, estradiol/progesterone combination on the bone mineral density and biomechanical properties of ovariectomized rats’ bone. …”
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    Biomechanical properties of osteoporotic rat femurs after different hormonal treatments: genistein, estradiol, and estradiol/progesterone
  14. 14
    “…However, there is wide individual variability in the dose response to oral estradiol, and approximately 25% of patients will not reach therapeutic goal on maximum oral estradiol. …”
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    Achieving Physiologic 17-ẞ-Estradiol Levels in Transgender Females on Estradiol Transdermal Patches and Optimal Dosing
  15. 15
    “…It is aimed to clarify the role of 17-estradiol (E2) in the battle against COVID-19. Materials and methods: Until April 2021, a study on PubMed was performed. …”
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    Estradiol and COVID-19: Does 17-Estradiol Have an Immune-Protective Function in Women Against Coronavirus?
  16. 16
    Publicado 2021
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    Corrigendum to: Genome-wide Association Study of Estradiol Levels and the Causal Effect of Estradiol on Bone Mineral Density
  17. 17
    por Friedman, A Edward
    Publicado 2005
    “…This article proposes a theory which resolves this apparent paradox. MODEL: The Estradiol-Dihydrotestosterone(E-D) model introduced in this paper proposes that 17β-estradiol(E2) is essential for initiating the growth of PCa cells through the formation of telomeres. …”
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    The Estradiol-Dihydrotestosterone model of prostate cancer
  18. 18
    “…The influence of estradiol upon incorporation of isotopes into the sulfated acid mucopolysaccharides of connective tissues of the rat has been studied. …”
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    INHIBITION OF SYNTHESIS OF SULFATED MUCOPOLYSACCHARIDES BY ESTRADIOL
  19. 19
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    Experimental Hepatotoxicity Produced by Ethinyl estradiol
  20. 20
    “…Treatment of MCF7 cells with estradiol caused enrichment of RAD21 binding at upstream enhancers and at the P2 promoter of MYC. …”
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    Cohesin Is Required for Activation of MYC by Estradiol
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