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  1. 42461
    por Ogorevc, J., Orehek, S., Dovč, P.
    Publicado 2016
    “…Induced pluripotent stem cells (iPSCs) represent practically limitless, ethically acceptable, individuum-specific source of pluripotent cells that can be generated from different types of somatic cells. iPSCs can differentiate to all cell types of an organism’s body and have a tremendous potential for numerous applications in medicine, agriculture, and biotechnology. …”
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    Cellular reprogramming in farm animals: an overview of iPSC generation in the mammalian farm animal species
  2. 42462
    por Mponda, Kelvin, Masenga, John
    Publicado 2016
    “…Diagnoses were clinical, diagnostic tests being done only when necessary. Ethical clearance to conduct the study was granted. …”
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    Skin diseases among elderly patients attending skin clinic at the Regional Dermatology Training Centre, Northern Tanzania: a cross-sectional study
  3. 42463
    “…(7) Would these options be feasible and sustainable in this specific context? (8) What are the ethical, legal and social implications of choosing one option over another? …”
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    Evidence for Health III: Making evidence-informed decisions that integrate values and context
  4. 42464
    por Nater, Anick, Fehlings, Michael G.
    Publicado 2016
    “…Given the dearth of medical equipoise and the fundamental difference between patients deemed to be adequate surgical candidates and those who are not amenable to operative intervention, conducting a randomized controlled trial in this patient population was not felt to be ethically or medically feasible. Consequently, the optimal option to overcome limitations of both the lack of controls and the relatively small sample size is through collection of large prospective datasets through rigorously developed and maintained registries. …”
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    Survival and clinical outcomes in patients with metastatic epidural spinal cord compression after spinal surgery: a prospective, multicenter, observational cohort study
  5. 42465
    “…BACKGROUND: Community Treatment Orders (CTOs) are often complex because of the ethical tensions created by an intervention that aims at promoting the patient’s good through an inherently coercive process. …”
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    Examining the use of metaphors to understand the experience of community treatment orders for patients and mental health workers
  6. 42466
    “…Risks, complications, and long-term outcomes and resources need to be considered and weighed in before widespread application. Ethical challenges are a reality and a multidisciplinary approach that should be adopted for every case in consideration.…”
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    Adult venovenous extracorporeal membrane oxygenation for severe respiratory failure: Current status and future perspectives
  7. 42467
    “…However, integrated qualitative studies in such trials are needed to enable a broader evaluation of patient experiences in the trial, with important ethical and practical implications for the design and conduct of similar trials and treatment regimes in the future. …”
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    “I didn’t really understand it, I just thought it’d help”: exploring the motivations, understandings and experiences of patients with advanced lung cancer participating in a non-placebo clinical IMP trial
  8. 42468
    “…The use of iPSCs and direct somatic cell fate conversion, or transdifferentiation, holds great promise for regenerative medicine as these techniques may circumvent obstacles related to immunological rejection and ethical considerations. However, producing iPSC-derived keratinocytes requires a lengthy two-step process of initially generating iPSCs and subsequently differentiating into skin cells, thereby elevating the risk of cellular damage accumulation and tumor formation. …”
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    Direct conversion of mouse embryonic fibroblasts into functional keratinocytes through transient expression of pluripotency-related genes
  9. 42469
    “…The protocol was approved by the National Committee and Ethical Committee Board from the Mexican Social Security Institute (IMSS) (IMSS FIS/IMSS/PRIO/10/011).…”
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    Expression of candidate genes associated with obesity in peripheral white blood cells of Mexican children
  10. 42470
    “…Abortion evokes religious, moral, ethical, socio-cultural and medical concerns which mean it is highly stigmatized and this poses a threat to both providers and researchers. …”
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    Stigmatized by association: challenges for abortion service providers in Ghana
  11. 42471
    “…It consists of 12 sections that cover all aspects of clinical management of oropharyngeal dysphagia (OD) related to geriatric medicine and discusses prevalence, quality of life, and legal and ethical issues, as well as health economics and social burden. …”
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    European Society for Swallowing Disorders – European Union Geriatric Medicine Society white paper: oropharyngeal dysphagia as a geriatric syndrome
  12. 42472
    “…Shifting policies towards legalisation of cannabis for therapeutic and recreational use raise significant ethical issues for health-care providers seeking evidence-based recommendations. …”
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    Hippocampal harms, protection and recovery following regular cannabis use
  13. 42473
    “…Geographic variations in eligibility for financial support pose an ethical problem that needs policy attention. An appropriate balance between public spending on continuation of therapy and improved quality of life derived from it should be explored.…”
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    Effects of financial support on treatment of adolescents with growth hormone deficiency: a retrospective study in Japan
  14. 42474
    “…BACKGROUND: In the development of new drugs for severe asthma, it is a challenge from an ethical point of view to randomize severe asthma patients to placebo, and to obtain long-term safety data due to discontinuations. …”
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    Evaluation of the use of Swedish integrated electronic health records and register health care data as support clinical trials in severe asthma: the PACEHR study
  15. 42475
    “…CONCLUSIONS: As the world moves beyond the charity model of global health (and its colonial roots), it is evident that the issue underlying ethical global health practice is partnership and the pursuit of health equity. …”
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    The future of global health education: training for equity in global health
  16. 42476
    “…Main areas covered were: social, ethical, relational aspects of disease and communication, training, research, organizational and management models in SC. …”
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    Early Integration of Palliative Care in Oncology Practice: Results of the Italian Association of Medical Oncology (AIOM) Survey
  17. 42477
    por Pratt, Bridget, Hyder, Adnan A.
    Publicado 2016
    “…For such research to do so, ethical guidance that is consistent with egalitarian theories of social justice proposes it ought to (amongst other things) focus on worst-off countries and research populations. …”
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    How can health systems research reach the worst-off? A conceptual exploration
  18. 42478
    “…The study has received full ethical approval from the Bahrain Ministry of Health and from the affiliated university. …”
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    Predictors of Vascular Cognitive Impairment Poststroke in a Middle Eastern (Bahrain) Cohort: A Proposed Case-Control Comparison
  19. 42479
    “…BACKGROUND: The use of restraints in adolescent psychiatric settings requires particular professional, ethical, and legal considerations. The purpose of this study was to investigate whether the number of restraint episodes per patient was related to any of several characteristics of the adolescents. …”
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    Characteristics of adolescents frequently restrained in acute psychiatric units in Norway: a nationwide study
  20. 42480
    “…Because of the issues (ethical and religious) involved in the use of embryonic stem cells and the limited plasticity of adult stem cells, an alternative cell source could be foetal stem cells derived from extra-embryonic tissue, which are highly proliferative, grow in vitro and possess interesting immunogenic characteristics. …”
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    Phenotype and multipotency of rabbit (Oryctolagus cuniculus) amniotic stem cells
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