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  1. 42981
    “…This study addresses uncertainties relating to care needs of patients and carers at different stages of the IPF disease trajectory. METHODS: Following ethical approval a multi-centre mixed-methods study recruited participants with IPF at four stages of the disease trajectory. …”
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    The care needs of patients with idiopathic pulmonary fibrosis and their carers (CaNoPy): results of a qualitative study
  2. 42982
    “…Compared with embryonic stem cells, induced pluripotent stem cells (iPSCs) can be derived from adult somatic cells, and they are associated with fewer ethical concerns and are less prone to immune rejection. …”
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    Modeling autosomal dominant optic atrophy using induced pluripotent stem cells and identifying potential therapeutic targets
  3. 42983
    “…In conclusion, the DOI has provided an ethical framework for engagement of health professionals from south-eastern European countries. …”
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    Improvement in kidney transplantation in the Balkans after the Istanbul Declaration: where do we stand today?
  4. 42984
    “…MATERIALS AND METHODS: From June 2010 to March 2012, 1080 consecutive female patients with breast lesions were recruited into a multicenter retrospective study, which involved 8 centers across China. Each institutional ethic review board approved the study, and all the patients gave written informed consent. …”
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    Ultrasonic Elastography Research Based on a Multicenter Study: Adding Strain Ratio after 5-Point Scoring Evaluation or Not
  5. 42985
    “…However, RCTs cannot always be applied for practical or ethical reasons. To investigate the current practices in rare diseases, we review evaluations of therapeutic interventions in paediatric multiple sclerosis (MS) and Creutzfeldt-Jakob disease (CJD). …”
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    Systematic reviews in paediatric multiple sclerosis and Creutzfeldt-Jakob disease exemplify shortcomings in methods used to evaluate therapies in rare conditions
  6. 42986
    “…CONCLUSION: Rather than forbidding any connection between doctors and industry, it is better to establish ethical guidelines. The Medical Council of India code is a step in the right direction, but the majority of doctors in this study have not read the guidelines about interacting with the pharmaceutical industry or its representative.…”
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    A study on the interactions of doctors with medical representatives of pharmaceutical companies in a Tertiary Care Teaching Hospital of South India
  7. 42987
    “…CONCLUSIONS: The introduction of new National Institute for Health and Care Excellence (NICE) CKD guidelines in 2014, which focus the meaning and purpose of CKD monitoring by increased proteinuria testing and assessment of risk, may help to resolve some of the ethical and moral tensions clinicians expressed regarding the overmedicalisation of patients with a CKD diagnosis.…”
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    Understanding tensions and identifying clinician agreement on improvements to early-stage chronic kidney disease monitoring in primary care: a qualitative study
  8. 42988
    “…CONCLUSIONS: The study reinforces the ethical imperative to ensure trial participants who are Deaf are provided with optimum resources to understand the implications of participation and to make an informed choice. …”
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    A qualitative exploration of trial-related terminology in a study involving Deaf British Sign Language users
  9. 42989
    “…Sample size is often increased through centralized pooling of disparately located datasets, though ethical, privacy and data ownership issues can often hamper this process. …”
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    ViPAR: a software platform for the Virtual Pooling and Analysis of Research Data
  10. 42990
    “…Comparably reductionist experiments are neither technically nor ethically possible in humans. Despite revealing many fundamental principals of immunology, there is growing concern that mice fail to capture relevant aspects of the human immune system, which may account for failures to translate disease treatments from bench to bedside(1–8). …”
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    Recapitulating adult human immune traits in laboratory mice by normalizing environment
  11. 42991
    “…The majority of these patients are managed by the attending physician, yet, a small group, mostly coincident with the worst presentation and outcomes, requires nephrology consultation, challenging the clinician with ethical issues regarding the decision to initiate or forgo renal support therapy. …”
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    Haematological malignancies and acute kidney injury requiring nephrology consultation: challenging the worst of the worst
  12. 42992
    “…We investigated whether we could objectify cognitive complaints in aircrew and whether we could find a neurobiological substrate for their complaints. After medical ethical approval from the local institutional review board, informed consent was obtained from 12 aircrew (2 females, on average aged 44.4 years, 8,130 flying hours) with cognitive complaints and 11 well matched control subjects (2 females, 43.4 years, 233 flying hours). …”
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    Cognitive impairment and associated loss in brain white microstructure in aircrew members exposed to engine oil fumes
  13. 42993
    por Clasen, Thomas, Boisson, Sophie
    Publicado 2015
    “…OBJECTIVES: We summarize the results of blinded versus open trials of water quality interventions, describe evidence from a recent placebo-controlled trial in India suggesting that control households were put at risk from their participation, and suggest alternatives to blinded trials that could resolve continued uncertainty about the magnitude of the protective effect of water, sanitation, and hygiene (WASH) interventions without presenting ethical questions. DISCUSSION: Concerns about reporting bias in open trial designs continue to cause uncertainty about the effectiveness of WASH interventions. …”
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    Assessing the Health Impact of Water Quality Interventions in Low-Income Settings: Concerns Associated with Blinded Trials and the Need for Objective Outcomes
  14. 42994
    “…The rejection of these ethically problematic and costly extremes is good news for biobanks. …”
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    Understanding the Public’s Reservations about Broad Consent and Study-By-Study Consent for Donations to a Biobank: Results of a National Survey
  15. 42995
    “…Human endometrium (n = 41) was collected with ethical approval and subject consent. Donor peripheral blood monocyte-derived macrophages were treated with estradiol, progesterone, or cortisol. …”
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    Cortisol regulates the paracrine action of macrophages by inducing vasoactive gene expression in endometrial cells
  16. 42996
    “…MATERIALS AND METHODS: After Ethical Committee approval, 50 patients (age range 20-65 years) from our pain clinic NIVARANE who met the Diagnostic and Statistical Manual of Mental Disorders 4(th) edition criteria for primary insomnia were randomized to receive melatonin 3 mg or placebo at 7 pm orally every day for 14 days from our pharmacist. …”
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    The Efficacy of Oral Melatonin in Improving Sleep in Cancer Patients with Insomnia: A Randomized Double-Blind Placebo-Controlled Study
  17. 42997
    “…After written informed consent and ethical clearance, total 90 subjects were enrolled. …”
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    Diagnostic and prognostic significance of serum soluble endoglin levels in preeclampsia and eclampsia
  18. 42998
    “…DESIGN, SETTING, AND PARTICIPANTS: This was an ethically approved prospective, single-blinded, placebo-controlled study. …”
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    Investigating the KNDy Hypothesis in Humans by Coadministration of Kisspeptin, Neurokinin B, and Naltrexone in Men
  19. 42999
    “…A regression model will also be used to adjust for stratification factor. DISCUSSION: The ethical committee at Karolinska Institutet has approved the study. …”
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    Cemented compared to uncemented femoral stems in total hip replacement for displaced femoral neck fractures in the elderly: study protocol for a single-blinded, randomized controlled trial (CHANCE-trial)
  20. 43000
    “…A significant proportion of students were aware of the ethical violations in academic transgressions (P ≤ 0.004 for all transgressions), but a large proportion of students also perceived academic cheating as a collective effort and were likely to engage people randomly (P ≤ 0.001 for all, but the most severe transgression). …”
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    No difference in the intention to engage others in academic transgression among medical students from neighboring countries: a cross-national study on medical students from Bosnia and Herzegovina, Croatia, and Macedonia
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