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46901por Riddell, Michaela A., Edwards, Nancy, Thompson, Simon R., Bernabe-Ortiz, Antonio, Praveen, Devarsetty, Johnson, Claire, Kengne, Andre P., Liu, Peter, McCready, Tara, Ng, Eleanor, Nieuwlaat, Robby, Ovbiagele, Bruce, Owolabi, Mayowa, Peiris, David, Thrift, Amanda G., Tobe, Sheldon, Yusoff, Khalid“…RESULTS: Important issues were identified during the data harmonisation process relating to data ownership, sharing methodologies and ethical concerns. Measures were assessed across eight domains; demographic; dietary; clinical and anthropometric; medical history; hypertension knowledge; physical activity; behavioural (smoking and alcohol); and biochemical domains. …”
Publicado 2017
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46902“…However, physicians’ professional training and experience create a vast knowledge gap in medical matters between physicians and patients. This raises ethical concerns about the relevance and significance of health care consumers’ evaluation of physicians’ performance. …”
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46903por Wade, Julia, Elliott, Daisy, Avery, Kerry N. L., Gaunt, Daisy, Young, Grace J., Barnes, Rebecca, Paramasivan, Sangeetha, Campbell, W Bruce, Blazeby, Jane M., Birtle, Alison J, Stein, Rob C., Beard, David J, Halliday, Alison W, Donovan, Jenny L.“…BACKGROUND: Informed consent (IC) is an ethical and legal prerequisite for trial participation, yet current approaches evaluating participant understanding for IC during recruitment lack consistency. …”
Publicado 2017
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46904por Dósa, Edit, Heltai, Krisztina, Radovits, Tamás, Molnár, Gabriella, Kapocsi, Judit, Merkely, Béla, Fu, Rongwei, Doolittle, Nancy D., Tóth, Gerda B., Urdang, Zachary, Neuwelt, Edward A.“…The purpose of this study was to establish the maximum tolerated dose (MTD) and pharmacokinetics of both intravenous (IV) and intra-arterial (IA) NAC in adults with chronic kidney disease to be used in further trials on oto- and nephroprotection in pediatric patients receiving platinum therapy. METHODS: Due to ethical considerations in pediatric tumor patients, we used a clinical population of adults with non-neoplastic disease. …”
Publicado 2017
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46905“…We aimed to describe how routine coagulation test results change during oesophagectomy’s perioperative course. METHODS: Following ethical approval, we retrospectively identified patients who had undergone oesophagectomy between 2002 and 2012. …”
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46906por Bousquet, Cedric, Dahamna, Badisse, Guillemin-Lanne, Sylvie, Darmoni, Stefan J, Faviez, Carole, Huot, Charles, Katsahian, Sandrine, Leroux, Vincent, Pereira, Suzanne, Richard, Christophe, Schück, Stéphane, Souvignet, Julien, Lillo-Le Louët, Agnès, Texier, Nathalie“…METHODS: In this article, we propose methods and describe the advancement of this project on several aspects: (1) a quality driven approach for selecting relevant social media for the extraction of knowledge on potential ADRs, (2) an assessment of ethical issues and French regulation for the analysis of data on social media, (3) an analysis of pharmacovigilance expert requirements when reviewing patient posts on the Internet, (4) an extraction method based on natural language processing, pattern based matching, and selection of relevant medical concepts in reference terminologies, and (5) specifications of a component-based architecture for the monitoring system. …”
Publicado 2017
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46907por Nicolai, Leo, Schmidbauer, Moritz, Gradel, Maximilian, Ferch, Sabine, Antón, Sofía, Hoppe, Boj, Pander, Tanja, von der Borch, Philip, Pinilla, Severin, Fischer, Martin, Dimitriadis, Konstantinos“…CONCLUSIONS: For the moment, the medical faculty has no active involvement in these groups and therefore no influence on accuracy of information, professionalism, and ethical issues. Nevertheless, faculty could in the future benefit by extracting relevant information, identifying common problems, and understanding semester-related dynamics.…”
Publicado 2017
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46908por Skinner, Elizabeth H., Lloyd, Melanie, Janus, Edward, Ong, May Lea, Karahalios, Amalia, Haines, Terry P., Kelly, Anne-Maree, Shackell, Melina, Karunajeewa, Harin“…Its stepped-wedge randomised controlled trial design provides a means to address some significant ethical, organisational and other methodological challenges to evaluating the effectiveness of health-service interventions in complex hospital populations. …”
Publicado 2018
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46909por Vousden, Nicola, Lawley, Elodie, Nathan, Hannah L., Seed, Paul T., Brown, Adrian, Muchengwa, Tafadzwa, Charantimath, Umesh, Bellad, Mrutyunjaya, Gidiri, Muchabayiwa Francis, Goudar, Shivaprasad, Chappell, Lucy C., Sandall, Jane, Shennan, Andrew H.“…Nine of the ten main trial sites achieved ethical approval for pilot data collection. Intensive care was an inconsistent marker of morbidity and stroke an infrequent outcome and therefore they were removed from the main trial composite outcome. …”
Publicado 2018
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46910por Prowse, Rachel J. L., Naylor, Patti-Jean, Olstad, Dana Lee, Carson, Valerie, Storey, Kate, Mâsse, Louise C., Kirk, Sara F. L., Raine, Kim D.“…Policy makers should provide explicit food marketing regulations that complement provincial nutrition guidelines to fulfill their ethical responsibility to protect children and the settings where children spend time.…”
Publicado 2018
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46911por Ajumobi, Olufemi, Uhomoibhi, Perpetua, Onyiah, Pamela, Babalola, Obafemi, Sharafadeen, Salami, Ughasoro, Maduka D., Adamu, Al-Mukhtar Y., Odeyinka, Oluwaseun, Orimogunje, Taiwo, Maikore, Ibrahim, Shekarau, Emmanuel, Ogunwale, Akintayo, Afolabi, Rotimi, Udeh, Sylvester, Ndubuisi, Akpuh, Umoette, Ntiense, Nguku, Patrick, Ajayi, IkeOluwapo O.“…RESULTS: A structured framework, study protocol and data collection instruments were developed and submitted for ethical approval. The instruments included survey questionnaire for detailed information on researchers and other stakeholders’ experience with MOR, the gaps and needs in thematic MOR areas; KII and Delphi guides. …”
Publicado 2018
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46912por Milko, Laura V., Rini, Christine, Lewis, Megan A., Butterfield, Rita M., Lin, Feng-Chang, Paquin, Ryan S., Powell, Bradford C., Roche, Myra I., Souris, Katherine J., Bailey, Donald B., Berg, Jonathan S., Powell, Cynthia M.“…BACKGROUND: Using next-generation sequencing (NGS) in newborn screening (NBS) could expand the number of genetic conditions detected pre-symptomatically, simultaneously challenging current precedents, raising ethical concerns, and extending the role of parental decision-making in NBS. …”
Publicado 2018
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46913por Mole, Damian J., Fallowfield, Jonathan A., Kendall, Timothy J., Welsh, Fenella, Semple, Scott I., Bachtiar, Velicia, Kelly, Matt, Wigmore, Stephen J., James Garden, O., Wilman, Henry R., Banerjee, Rajarshi, Rees, Myrddin, Brady, Michael“…The primary outcome is correlation between the pre-operative liver health assessment score (Hepatica score - calculated by weighting future remnant liver volume by liver inflammation and fibrosis (LIF) score) and the post-operative liver function composite integer-based risk (Hyder-Pawlik) score. With ethical approval and fully-informed consent, individuals considering liver surgery for primary or secondary cancer will undergo clinical assessment, blood sampling, and LiverMultiScan™multiparametric MRI before and after surgical liver resection or TACE. …”
Publicado 2018
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46914por Sones, William, Julious, Steven A., Rothwell, Joanne C., Ramsay, Craig Robert, Hampson, Lisa V., Emsley, Richard, Walters, Stephen J., Hewitt, Catherine, Bland, Martin, Fergusson, Dean A., Berlin, Jesse A., Altman, Doug, Vale, Luke David, Cook, Jonathan Alistair“…The sample size has many implications for the conduct of the study, as well as incurring scientific and ethical aspects. Despite the critical role of the target difference for the primary outcome in the design of a randomised controlled trial (RCT), the manner in which it is determined has received little attention. …”
Publicado 2018
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46915“…Irrespective of the positive role SDs play in the health care process, the negative effects of their use mandate proper regulation, in particular, an ethical mandate that takes into consideration the significant consequences that the use of SDs may have on care processes and outcomes.…”
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46916por Maddison, Ralph, Cartledge, Susie, Rogerson, Michelle, Goedhart, Nicole Sylvia, Ragbir Singh, Tarveen, Neil, Christopher, Phung, Dinh, Ball, Kylie“…Most studies highlighted technical or ethical issues associated with using wearable cameras, many of which were overcome. …”
Publicado 2019
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46917por Guisado-Fernández, Estefanía, Giunti, Guido, Mackey, Laura M, Blake, Catherine, Caulfield, Brian Michael“…RESULTS: Emerging themes were built in a way that said something specific and meaningful about the research question, creating a list of factors influencing the adoption of s-Health technologies for PwD and their informal caregivers, including attitudinal aspects, ethical issues, technology-related challenges, condition-related challenges, and identified gaps. …”
Publicado 2019
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46918por Smit, Menno R, Ochomo, Eric O, Aljayyoussi, Ghaith, Kwambai, Titus K, Abong’o, Bernard O, Bousema, Teun, Waterhouse, David, Bayoh, Nabie M, Gimnig, John E, Samuels, Aaron M, Desai, Meghna R, Phillips-Howard, Penelope A, Kariuki, Simon K, Wang, Duolao, Ward, Stephen A, ter Kuile, Feiko O“…Membrane feeding, which is more patient friendly and ethically acceptable, can likely reliably be used to assess ivermectin’s mosquitocidal efficacy. …”
Publicado 2019
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46919por Varma, A., Jensen, A. K. G., Thysen, S. M., Pedersen, L. M., Aaby, P., Fisker, A. B.“…Secondary outcomes are: non-accidental death, repeated non-fatal hospitalizations with overnight stay, cause-specific primary outcome, outpatient visit, and illness. We obtained ethical approval from Guinea-Bissau and consultative approval from Denmark. …”
Publicado 2019
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46920por Chemtob, Daniel, Rich, Rivka, Harel, Neta, Averick, Nechama, Schwartzberg, Eyal, Yust, Israel, Maayan, Shlomo, Grotto, Itamar, Gamzu, Ronni“…Demographic and serological data of patients referred between 2014 to 2018 were collected to monitor progress. and analyze preliminary medical and biological outcomes. Ethical approval was obtained from the Ministry of Health. …”
Publicado 2019
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