“…METHODS AND MATERIALS: We compared photon-DIBH (Ph-DIBH) versus proton DIBH (Pr-DIBH) for different planning parameters, including target coverage and organ at risk (OAR) sparing. Necessary ethical permission was obtained from the institutional review board. …”
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“…CONCLUSIONS AND RELEVANCE: These findings suggest that clinicians must consider the ethical implications of the influence of altruism when patients participate in the decision between cost-effective vs the most effective medicines for their own health care.…”
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“…These challenges include lack of security guidelines and regulations for developing secure mHealth apps (20/32, 63%), developers’ lack of knowledge and expertise for secure mHealth app development (18/32, 56%), lack of stakeholders’ involvement during mHealth app development (6/32, 19%), no/little developer attention towards the security of mHealth apps (5/32, 16%), lack of resources for developing a secure mHealth app (4/32, 13%), project constraints during the mHealth app development process (4/32, 13%), lack of security testing during mHealth app development (4/32, 13%), developers’ lack of motivation and ethical considerations (3/32, 9%), and lack of security experts’ engagement during mHealth app development (2/32, 6%). …”
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“…BACKGROUND: The implementation of eHealth in low-resource countries (LRCs) is challenged by limited resources and infrastructure, lack of focus on eHealth agendas, ethical and legal considerations, lack of common system interoperability standards, unreliable power, and shortage of trained workers. …”
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“…Although tissue biopsies and/or animal models represent the best models to study IBD onset, progression, and clinical interventions, they are both affected by limitations such as invasiveness, cost- and time-consuming, and ethical issues such as animal suffering. Here we propose a novel approach based on the cultivation of mouse tissues (colon) in an ex vivo microfluidic device (Gut-Ex-Vivo System, GEVS) to study IBD. …”
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“…Medical informatics may also help support public health actions and clinical interventions - but scalability and impact will depend on overcoming ingrained human shortcomings to deal with complex socio-economic, political, and technological disruptions together with the many ethical challenges presented by pandemics. Objectives : The principal goal is to review the history of biomedical information and healthcare practices related to past pandemics in order to illustrate just how exceptional and dependent on biomedical informatics are the recent scientific insights into human immune responses to viral infection, which are enabling rapid antiviral vaccine development and clinical management of severe cases – despite the many societal challenges ahead. …”
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“…CEOs should value the influence of organizational trust and improve his/her own social and work abilities on middle-level managers as the organizational trust of middle-level managers has a significant positive impact on their sense of responsibility, ethical behavior, organizational commitment, job satisfaction, and performance. …”
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“…All the assumptions of the Helsinki Declaration have been fulfilled and an informed consent for clinical case of Clínica Dentária Egas Moniz approved by the ethic commission of Instituto Universitário Egas Moniz. …”
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“…The study was conducted in accordance with all the ethical principles. RESULTS: We found significant statistical positive correlations between the total score of the CTQ and the total score of the DERS (r = 0.422, p<.001) and the sub-scales of DERS: the not acceptance of emotional responses (r = 0.311, p=.002), difficulties engaging in goal-directed behaviour (r = 0.243, p=.017), impulse control difficulties (r = 0.431, p<.001)), limited access to emotion regulation strategies (r = 0.465, p<.001), and lack of emotional clarity (r = 0.209, p=.041). …”
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“…A total of 19 participants, including physicians, nurses, and hospital managers, were engaged in the study. Ethical clearance was granted by the University research committee and the respective hospitals. …”
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“…Additionally, we collected demographic information. The hospital's ethical review committee approved our study design. …”
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“…Given the ever-evolving nature of such technological platforms and the complex ethical–legal landscape, such platforms must be safe and secure to ensure widespread public trust and uptake.…”
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“…SIMPLE SUMMARY: A reduction in lamb mortality would benefit farmers both economically and ethically. The major causes of lamb mortality are similar worldwide. …”
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“…A computer-generated simple random sampling technique was employed to select the study participants. Ethical clearance was obtained from the Institutional Review Board of Bahir Dar University, and also, we got implied consent to review charts from the concerned bodies in the hospital. …”
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“…Data were collected after ethical approval from 1st January 2020 to 20th January 2020 during the second COVID-19 wave. …”
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“…(1) Background: Three-dimensional (3D) collagen I-based skin models are commonly used in drug development and substance testing but have major drawbacks such as batch-to-batch variations and ethical concerns. Recently, synthetic nanofibrous scaffolds created by electrospinning have received increasing interest as potential alternatives due to their morphological similarities to native collagen fibrils in size and orientation. …”
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“…Initially ciprofloxacin was prescribed at 750 to 500 mg twice daily and the dose and duration of treatment was personalized according to pain scores and ESR. No ethical approval was required since this was an observational study of standard management of this condition at the Trust. …”
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“…Importantly, significant programmatic challenges endure pertaining to a clear drug and biological product development pathway for therapeutics targeting biodefense and emerging pathogens when human efficacy studies are not ethical or feasible. For example, remdesivir’s clinical development was facilitated by outbreaks of Ebola and SARS-CoV-2; as such, the development pathway employed for remdesivir is likely to be the exception rather than the rule. …”
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“…IMPORTANCE: The World Health Organization (WHO) designates early integration of palliative care as an ethical responsibility in the treatment of children with serious illness. …”
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“…In conclusion, the use of in vitro and ex vivo models allows for numerous experimental replications in a short period, with little or no ethical constraints and limited confounding factors.…”
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