“…The explant culture protocol was first optimized to determine the ideal conditions in terms of tissue viability before performing the actual experiments involving active and inactive bacteria with or without protein synthesis inhibitors, such as LY294002 (phosphatidylinositol 3-kinase inhibitor) or rapamycin [mammalian target of rapamycin (mTOR) inhibitor]. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Similarly, mTORC1 as well as mTORC2 have the same protective effects in mitochondria damage and apoptosis. In in vivo experiments of ALI mouse, HGF also increased mitochondria structural integrity via the mTOR/STAT3 pathway. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The liver cancer was induced to the rats by injecting a DEN (200 mg/kg) on the 8th day of experiment. Then DEN-induced rats treated with 10 mg/kg of formulated SCPg-AI-NCs an hour before DEN administration for 16 weeks. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…MATERIALS AND METHODS: A total of 35 patients with BD and 33 healthy controls underwent 3D-ASL and DKI experiments. The perfusion parameter of cerebral blood flow (CBF), diffusion parameters of fractional anisotropy (FA), mean/axial/radial diffusivity (MD/Da/Dr), and kurtosis parameters of anisotropy fraction of kurtosis (FAk) and mean/axial/radial kurtosis MK/Ka/Kr were obtained to quantitatively measure the parametric distributions of functional brain subregions. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: People differ strongly in their bodily reactions and psychological experiences during the first months of their addiction treatment. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: The plasma analysis showed cTnT and CK-MB expression peaked at 24 h after symptom onset; miR-208b, miR-21, TGF-β1, and Smad-3 levels showed no peak and increased gradually with time. Cell experiments revealed that miR-208b and TGF-β1 were upregulated along with increased hypoxia exposure; miR-21 expression peaked at 24 h and 72 h, with the highest peak at 72 h, and Smad-3 expression peaked at 6 h and 72 h, with the highest peak at 72 h. miR-208b and miR-21 expressions were positively correlated with TGF-β/Smad-3 expression. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In addition, high expression of miR-100-5p in hUC-MSC-sEVs was identified by Q-PCR, and the functional role of sEVs-miR-100-5p on macrophages was explored by a series of co-culture experiments using sEVs derived from hUC-MSCs transfected with miR-100-5p inhibitor. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Female students were more willing to be vaccinated against HPV, if they had higher living expenses (AOR = 1.395 and 3.717, 95% CI: 1.071–1.426 and 1.776–7.752), relatives or friends had certain cancer (AOR = 1.290, 95% CI: 1.095–1.518), ever had sexual experiences (AOR = 2.628, 95% CI: 1.788–3.863), and had ever consulted on HPV vaccination issues (AOR = 1.612, 95% CI: 1.367–1.901). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…There were no planned field experiments to explore and optimize the right time of sowing and quantity of fertilizer to be added previously due to the presence of negligible winter maize area. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Then, we explored the biological roles of circ‐TNPO3 in ccRCC via the function experiments in vitro and in vivo. RNA pull‐down, RNA immunoprecipitation, bioinformatic analysis, RNA‐FISH assays and rescue assays were applied to validate the interactions between circ‐TNPO3, insulin‐like growth factor 2 mRNA‐binding protein 2 (IGF2BP2) and serpin family H member 1 (SERPINH1) to uncover the underlying molecular mechanisms of circ‐TNPO3. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Three primiparous Jersey cows were enrolled in the experiment, and PCLS from each were prepared prepartum (−8.0 ± 3.6 DIM) and postpartum (+7.7± 1.2 DIM) and treated independently with a variety of PPAR agonists and antagonists: the PPARα agonist WY-14643 and antagonist GW-6471; the PPARδ agonist GW-50156 and antagonist GSK-3787; and the PPARγ agonist rosiglitazone and antagonist GW-9662. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In in vitro fertilization (IVF) experiments, sperm from Pla2g10-deficient mice produces fewer two-cell embryos, and the absence of PLA2G10 is rescued by adding recombinant enzymes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We demonstrate that specific combinations between TNFα, IL-1β and IFNγ up-regulated the proportion of human TNBC cells co-expressing the inhibitory immune checkpoints PD-L1 and PD-L2: TNFα + IL-1β in MDA-MB-231 cells and IFNγ + IL-1β in BT-549 cells; in the latter cells, the process depended entirely on STAT1 activation, with no involvement of p65 (CRISPR-Cas9 experiments). Highly significant associations between the pro-inflammatory cytokines and PD-L1/PD-L2 expression were revealed in the TCGA dataset of basal-like breast cancer patients. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Consistency between these in vitro data and in vivo experiments would provide new insights into potential mechanisms for HHV6-induced epileptogenesis.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…After 12 h of co-incubation of nPBMCs with VitD-dgVDBP, significant activation and expression were measured for CD16++/CD16 (0.6 ± 0.1% vs. 0.4 ± 0.1%, p < 0.05), CD45k(+) (96.0 ± 6.0% vs. 84.7 ± 9.5%, p < 0.05), CD85k(+) (24.3 ± 13.2% vs. 3.8 ± 3.2%, p < 0.05), and CD85k(+)/CD123(+) (46.8 ± 8.1% vs. 3.5 ± 3.7%, p < 0.001) compared to the control experiment. No significant difference was found using CD3+, CD4+, CD8+, CD4/CD8, CD4/CD8, CD16+, CD16++, CD14+, or CD123+. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The objective of this experiment was to determine the effects of increasing trace mineral (TM) supplementation on finishing cattle performance, carcass characteristics, TM balance, and antibody concentrations. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study was conducted at 6 academic medical centers in the United States, all participating in the Association of American Colleges Coordinating Optimal Referral Experiences program. Participants included adult patients who had an outpatient visit, referral, or eConsultation during the study period. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A pre-final version air purifier (Cleaning Air T12), capable of treating 210 m(3)/h of air, was first tested for its ability to filter particulates and reduce microbial air contamination in the absence of people. Subsequently, the experiments were conducted in the presence of 3–5 subjects who worked for several hours in an office. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A PLD1‐overexpression rescue experiment in these knockout cells was performed to further confirm its function. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Perhaps most importantly, this experiment demonstrates that selection within natural populations can be strong enough to measure sex‐specific fitness effects of individual loci. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso