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  1. 534841
    “…These original findings are now in question as it has been reported that the p-values associated with the tests of differential expression for null probesets (i.e., probesets designed to be fold change 1 across the two arms of the experiment) are not uniformly distributed. Two recent publications have speculated as to the reasons the null distributions are non-uniform. …”
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    Putative null distributions corresponding to tests of differential expression in the Golden Spike dataset are intensity dependent
  2. 534842
    “…This investigation illustrated how sequences derived from surface protein genes and computer simulations can be used to investigate variation generation mechanisms. Such in silico experiments of self-replicating sequences undergoing random mutations and genomic re-arrangements can offer insights into the diversity generation potential of the genes under study. …”
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    In silico, biologically-inspired modelling of genomic variation generation in surface proteins of Trypanosoma cruzi
  3. 534843
    “…The mutant colonies [white/pale blue on 5-bromo-4-chloro-3-indolyl beta-D-galactoside/isopropyl beta-D-thiogalactoside (X-gal/IPTG) plates] were selected, regrown and analysed by DNA sequencing. Mutagenesis experiments demonstrated that hydroquinones cause sequence-specific frameshift mutations involving deletion of a single cytosine from the DNA sequence 5'-172-CCCCC176-3' or a single guanosine from the complementary strand sequence 5'-GGGGG-3' in the supF tRNA gene. …”
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    Hydroquinones cause specific mutations and lead to cellular transformation and in vivo tumorigenesis.
  4. 534844
    “…Remarkably, [3H]vinblastine-sulphate binding competition experiments using P-gp-containing crude membrane preparations demonstrated similar dose dependencies as found for MDR reversion by the three modulators, i.e. decreasing efficacy in the series dexniguldipine-HCl > dexverapamil-HCl > GF 109203X. …”
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    Effects of the selective bisindolylmaleimide protein kinase C inhibitor GF 109203X on P-glycoprotein-mediated multidrug resistance.
  5. 534845
    por Rous, Peyton, Turner, J. R.
    Publicado 1916
    “…In the second part of this paper experiments are detailed which prove that cells preserved by the methods here recorded function excellently when reintroduced into the body.…”
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    THE PRESERVATION OF LIVING RED BLOOD CELLS IN VITRO : I. METHODS OF PRESERVATION.
  6. 534846
    “…Mice are the most suitable animals for these experiments, and they appear, as a rule, to escape fatal consequences. 8. …”
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    SPIROCHÆTA MORSUS MURIS, N.SP., THE CAUSE OF RAT-BITE FEVER : SECOND PAPER.
  7. 534847
    “…These adjustments within the organism, some of which may be thought to exhibit an element of the purposeful, when considered with the test-tube experiments, strongly suggest that the reaction of the bile plays a critical part in determining the occurrence of carbonate stones, as furthermore that their absence from the normal gall bladder is a consequence of the changes in the bile reaction there occurring. …”
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    OBSERVATIONS ON SOME CAUSES OF GALL STONE FORMATION : III. THE RELATION OF THE REACTION OF THE BILE TO EXPERIMENTAL CHOLELITHIASIS.
  8. 534848
    por Petroff, S. A., Steenken, William
    Publicado 1930
    “…After 2 years' study, using various media, we have been able to dissociate two types of colonies; but as the animal experiments are not yet completed, very little more than that can be said at present. …”
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    BIOLOGICAL STUDIES OF THE TUBERCLE BACILLUS : I. INSTABILITY OF THE ORGANISM—MICROBIC DISSOCIATION
  9. 534849
    por Wood, W. Barry
    Publicado 1941
    “…The relation of the observed phenomena to the curative action of anti-pneumococcal serum has been briefly discussed, and it is pointed out that the principal effect of antiserum is to cause immobilization of the pneumococci in the advancing edema zone. Experiments to be reported in a later publication have shown that sulfapyridine exerts a similar effect through a different mechanism.…”
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    STUDIES ON THE MECHANISM OF RECOVERY IN PNEUMOCOCCAL PNEUMONIA : I. THE ACTION OF TYPE SPECIFIC ANTIBODY UPON THE PULMONARY LESION OF EXPERIMENTAL PNEUMONIA
  10. 534850
    “…Since evidence in the literature indicates that there is an excess of sodium mainly limited to bone, which cannot be attributed to the extracellular phase, experiments on dogs and man were so devised that the ratio of tissue concentration to plasma concentration for radiosodium and chemically determined chloride could be calculated. …”
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    DETERMINATION OF THE VOLUME OF THE EXTRACELLULAR FLUID OF THE BODY WITH RADIOACTIVE SODIUM
  11. 534851
    “…Under the limited conditions of the present experiments, C viruses had no effect on the infection of chimpanzees with three different antigenic types of poliomyelitis virus. …”
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    QUANTITATIVE STUDIES OF THE VIRUS-HOST RELATIONSHIP IN CHIMPANZEES AFTER INAPPARENT INFECTION WITH COXSACKIE VIRUSES : I. THE VIRUS CARRIER STATE AND THE DEVELOPMENT OF NEUTRALIZING ANTIBODIES
  12. 534852
    por Miller, J. F. A. P., Mitchell, G. F.
    Publicado 1970
    “…Collaboration between thymus-derived lymphocytes, and nonthymus-derived antibody-forming cell precursors occurs during the immune response of mice to sheep erythrocytes (SRBC). The aim of the experiments reported here was to attempt to induce tolerance in each of the two cell populations to determine which cell type dictates the specificity of the response. …”
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    CELL TO CELL INTERACTION IN THE IMMUNE RESPONSE : V. TARGET CELLS FOR TOLERANCE INDUCTION
  13. 534853
    por Loeb, Jacques
    Publicado 1919
    “…Solutions of non-electrolytes, e.g. sugars, influence the initial rate of diffusion of water through the membrane approximately in direct proportion to their concentration, and this. influence begins to show itself under the conditions of our experiments when the concentration of the sugar solution is above M/64 or M/32. …”
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    INFLUENCE OF THE CONCENTRATION OF ELECTROLYTES ON THE ELECTRIFICATION AND THE RATE OF DIFFUSION OF WATER THROUGH COLLODION MEMBRANES
  14. 534854
    por Pollack, Herbert
    Publicado 1928
    “…The need of calcium to effect ameboid movement has been shown by Pantin (13) in a series of immersion experiments. This fact is quite suggestive, because the first effect of the injection of any of the calcium precipitants is absolute quiescence. …”
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    MICRURGICAL STUDIES IN CELL PHYSIOLOGY : VI. CALCIUM IONS IN LIVING PROTOPLASM.
  15. 534855
    Publicado 1990
    “…Immunoprecipitation experiments and two- dimensional PAGE analysis indicated that GL183-reactive molecules were represented in different clones either by a single 58-kD chain or, more frequently, by two chains of approximately 55 and approximately 58 kD, respectively. …”
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    A novel surface antigen expressed by a subset of human CD3- CD16+ natural killer cells. Role in cell activation and regulation of cytolytic function
  16. 534856
    Publicado 1990
    “…In sequential immunoprecipitation experiments using the double-positive clones CEG52 and CA25.50, preclearing of cell lysates with EB6 or GL183 mAb removed only EB6 or GL183 molecules, respectively, thus indicating that the two antigenic determinants are carried by two distinct molecules. …”
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    Identification of four subsets of human CD3-CD16+ natural killer (NK) cells by the expression of clonally distributed functional surface molecules: correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition
  17. 534857
    “…The Student Stress Survey and the Adolescent Coping Orientation for Problem Experiences Inventory (ACOPE) were used for data collection. …”
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    Experienced stressors and coping strategies among Iranian nursing students
  18. 534858
    “…Extending previously reported (3) experiments with other inhibitors, the effects of sodium azide and sodium sulfide on the respiration and cell division of fertilized Arbacia eggs were determined, the eggs being initially exposed to the reagents 30 minutes after fertilization at 20°C. …”
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    STUDIES ON CELL METABOLISM AND CELL DIVISION : V. CYTOCHROME OXIDASE ACTIVITY IN THE EGGS OF ARBACIA PUNCTULATA
  19. 534859
    “…These cells apparently disseminated and were detectable as early as day 50 in the peripheral blood of living mice, while the leukaemia manifestation was delayed by day 140. (3) In a transplantation experiment using mature human lymphocytes we wanted to standardise conditions for a successful survival of these cells in NOD/SCID mice. …”
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    Sensitive PCR method for the detection and real-time quantification of human cells in xenotransplantation systems
  20. 534860
    “…CONCLUSIONS: Overall, the enterprise-wide experiment was successful. On the level of individual websites, the project confirmed the value of online customer surveys as a Web evaluation method. …”
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    Web Evaluation at the US National Institutes of Health: Use of the American Customer Satisfaction Index Online Customer Survey
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