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536361por Johnson, Susan, Martinez, Clarissa, Cortese, Mario, Martinez, Josefina, Garg, Shaily, Peinovich, Nadine, Dora, Emery, Tucker, Sean“…The majority of subjects had an increase in S-specific anti-viral CD8(+) T cell responses. 19/26 (73%) subjects had a measurable CD8(+) T cell response on day 8 above baseline, on average 1.5-4.6%. In a comparator experiment with the 2 SARS-CoV-2 i.m. mRNA vaccines, VXA-CoV2-1 outperformed other vaccine candidates with a >3.5-fold increase in S specific antiviral CD8 T cell responses. …”
Publicado 2021
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536362por van Oirschot, Pim, Heerings, Marco, Wendrich, Karine, den Teuling, Bram, Dorssers, Frank, van Ee, René, Martens, Marijn Bart, Jongen, Peter Joseph“…We interviewed 7 study participants with MS regarding their experiences with the s2MWT. RESULTS: In total, 755 s2MWTs were completed. …”
Publicado 2021
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536363por Azman, Shazalyana, Sekar, Mahendran, Wahidin, Suzana, Gan, Siew Hua, Vaijanathappa, Jaishree, Bonam, Srinivasa Reddy, Alvala, Mallika, Lum, Pei Teng, Thakur, Vandana, Beladiya, Jayesh V, Mehta, Anita A“…Lung function parameters, including the respiratory rate, tidal volume and airflow rate were measured at the end of the experiment (day 42). The total and differential counts of leukocytes in the blood and bronchoalveolar fluid (BALF) were calculated. …”
Publicado 2021
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536364por Herrmann-Werner, Anne, Loda, Teresa, Zipfel, Stephan, Holderried, Martin, Holderried, Friederike, Erschens, Rebecca“…To optimize patients’ and health care professionals’ experiences with LTAs, future investigations should examine specific design options for training interventions and consider the legal aspects of human-machine interaction in health care settings.…”
Publicado 2021
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536365por Cho, Han Jin, Kim, Hyeonmok, Lee, Young‐Sun, Moon, Sung Ah, Kim, Jin‐Man, Kim, Hanjun, Kim, Min Ji, Yu, Jiyoung, Kim, Kyunggon, Baek, In‐Jeoung, Lee, Seung Hun, Ahn, Kyong Hoon, Kim, Sungsub, Kang, Jong‐Sun, Koh, Jung‐Min“…SLIT3 activated β‐catenin signalling by promoting its release from M‐cadherin, thereby increasing myogenin expression to stimulate myoblast differentiation. In vitro experiments involving ROBO2 expression, knockdown, and interaction with SLIT3 indicated that ROBO2 functions as a SLIT3 receptor to aid myoblast differentiation. …”
Publicado 2021
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536366por Liu, Yan‐Ling, Hu, Xiao‐Lei, Song, Pei‐Yuan, Li, He, Li, Mu‐Peng, Du, Yin‐Xiao, Li, Mo‐Yun, Ma, Qi‐Lin, Peng, Li‐Ming, Song, Ming‐Yu, Chen, Xiao‐Ping“…Loss‐of‐function and gain‐of‐function experiments were performed to reveal the regulation of GAS5 toward P2Y12 via miR‐223‐3p in MEG‐01 cells. …”
Publicado 2021
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536367por Vázquez, Sergio Muñoz, Endepols, Heike, Fischer, Thomas, Tawadros, Samir-Ghali, Hohberg, Melanie, Zimmermanns, Beate, Dietlein, Felix, Neumaier, Bernd, Drzezga, Alexander, Dietlein, Markus, Schomäcker, Klaus“…All radiotracers showed similar specific cellular binding and internalization, in vitro and comparable tumor uptake in biodistribution experiments during the first 5 h. The [(89)Zr]Zr-PSMA-DFO achieved significantly higher tumor/background ratios in LNCaP tumor xenografts (tumor/blood: 309 ± 89, tumor/muscle: 450 ± 38) after 24 h than [(68)Ga]Ga-PSMA-11 (tumor/blood: 112 ± 57, tumor/muscle: 58 ± 36) or [(18)F]F-JK-PSMA-7 (tumor/blood: 175 ± 30, tumor/muscle: 114 ± 14) after 4 h (p < 0.01). …”
Publicado 2021
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536368“…Potassium dichromate (K(2)Cr(2)O(7)) and selenium-enriched yeast (SeY) were used to construct the single Cr(6+) and combined Se/Cr(6+) exposure broiler models, and then the broilers were randomly divided into four groups (C group, Se group, Se/Cr(6+) group, and Cr(6+ )group). After a 42-day experiment, the spleen tissues of broilers were excised and weighted. …”
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536369por Li, Gao, Zhang, Yue, Du, Xiaowei, Li, Wanjun, Zhang, Yanming, Han, Tao, Zheng, Zhendong“…The results of the in vitro experiment were consistent with bioinformatic analysis. …”
Publicado 2020
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536370por Huberty, Jennifer, Bhuiyan, Nishat, Neher, Taylor, Joeman, Lynda, Mesa, Ruben, Larkey, Linda“…The majority of content preferences and suggestions that arose were cancer-specific, such as content related to negative emotions or feelings (eg, anxiety, grief, trauma/posttraumatic stress disorder, fear of recurrence, isolation), positive feelings and finding meaning (eg, gratitude, storytelling, acceptance), scenarios and experiences (eg, waiting, treatment-specific mediations), type and stage of cancer journey, and movement modifications. …”
Publicado 2022
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536371por Bickton, Fanuel Meckson, Mankhokwe, Talumba, Nightingale, Rebecca, Fombe, Cashon, Mitengo, Martha, Mwahimba, Langsfield, Lipita, Wilfred, Wilde, Laura, Pina, Ilaria, Yusuf, Zainab K, Ahmed, Zahira, Kamponda, Martin, Limbani, Felix, Shannon, Harriet, Chisati, Enock, Barton, Andy, Free, Robert C, Steiner, Michael, Matheson, Jesse A, Manise, Adrian, Singh, Sally J, Rylance, Jamie, Orme, Mark“…Pretrial semistructured in-depth interviews will explore their experiences of living with CRD and potential enablers and barriers to their PR uptake. …”
Publicado 2022
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536372por Bartels, Douglas, Hevesi, Mario, Wyles, Cody, Macalena, Jeffrey A., Kakar, Sanjeev, Krych, Aaron John“…OBJECTIVES: Participation in National Collegiate Athletic Association (NCAA) football is at an all-time high. This population experiences a substantial injury burden with many of these injuries affecting the upper extremities. …”
Publicado 2019
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536373por Yu, Jia-Ruei, Chen, Chun-Hsien, Huang, Tsung-Wei, Lu, Jang-Jih, Chung, Chia-Ru, Lin, Ting-Wei, Wu, Min-Hsien, Tseng, Yi-Ju, Wang, Hsin-Yao“…Compared with a five-hidden-layer NN, the XGB and LR algorithms achieved 16%-24% and 9%-13% lower power consumption levels for the mass spectrometry and urinalysis data sets, respectively. In all experiments, the XGB algorithm exhibited the best performance in terms of accuracy, run time, and energy efficiency. …”
Publicado 2022
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536374por Duan, Yanping, Liang, Wei, Wang, Yanping, Lippke, Sonia, Lin, Zhihua, Shang, Borui, Baker, Julien Steven“…The study also aims to explore participants’ experiences of participating in the health program. …”
Publicado 2022
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536375por Murkunde, Yogeshkumar Vishnupant, Chaudhary, Saransh, Vishwakarma, Kamlesh Kumar, Aggarwal, Anmol, Chilbule, Rahul“…Blood samples were collected prior to initiation of experiment and at 0.5, 1, 2, 4, 6, 8, 12 and 24 h after the last dose. …”
Publicado 2022
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536376por Notaras, Michael, Lodhi, Aiman, Barrio-Alonso, Estibaliz, Foord, Careen, Rodrick, Tori, Jones, Drew, Fang, Haoyun, Greening, David, Colak, Dilek“…We systemically exposed organoid samples to chemically defined “enviromimetic” compounds to examine the developmental effects of various narcotic and neuropsychiatric-related risk factors within tissue of human origin. In tandem experiments conducted in parallel, we modeled exposure to opiates (μ-opioid agonist endomorphin), cannabinoids (WIN 55,212-2), alcohol (ethanol), smoking (nicotine), chronic stress (human cortisol), and maternal immune activation (human Interleukin-17a; IL17a). …”
Publicado 2021
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536377“…Many of these disparities were known prior to the onset of pandemic, including unequal access to geriatric psychiatry educators and clinical experts across the country, as well as limited opportunities for clinical experiences in geriatric psychiatry for medical students and residents. …”
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536378por Mallis, Panagiotis, Chatzistamatiou, Theofanis, Dimou, Zetta, Sarri, Eirini-Faidra, Georgiou, Eleni, Salagianni, Maria, Triantafyllia, Vasiliki, Andreakos, Evangelos, Stavropoulos-Giokas, Catherine, Michalopoulos, Efstathios“…Finally, the interactions between MSCs and patients’ macrophages were established using co-culture experiments. RESULTS: Thawed WJ and BM-MSCs exhibited a spindle-shaped morphology, successfully differentiated to “osteocytes”, “adipocytes”, and “chondrocytes”, and in flow cytometric analysis were characterized by positivity for CD73, CD90, and CD105 (> 95%) and negativity for CD34, CD45, and HLA-DR (< 2%). …”
Publicado 2022
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536379por Xiong, Ying, Ruan, Yu-Ting, Zhao, Jing, Yang, Yu-Wen, Chen, Li-Ping, Mai, Ying-Ren, Yu, Qun, Cao, Zhi-Yu, Liu, Fei-Fei, Liao, Wang, Liu, Jun“…After MgT treatment, the viability of Aβ(25-35)-treated HT22 cells was determined via conducting cell counting kit-8 test and the cognition of APP/PS1 mice was measured through the Morris Water Maze. Flow cytometry experiments were applied to assess the ROS levels of HT22 cells and measure the apoptosis rate of HT22 cells or hippocampal neurons. …”
Publicado 2022
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536380por Meng, Xiangkun, Huang, Zhe, Inoue, Aiko, Wang, Hailong, Wan, Ying, Yue, Xueling, Xu, Shengnan, Jin, Xueying, Shi, Guo‐Ping, Kuzuya, Masafumi, Cheng, Xian Wu“…An IRS1 ubiquitin assay, and truncation, co‐immunoprecipitation, and co‐localization experiments were also performed. RESULTS: CTSK(+/+) cachectic animals exhibited loss of skeletal muscle mass (muscle weight loss of 15%, n = 10, P < 0.01), muscle dysfunction (grip strength loss > 15%, n = 10, P < 0.01), and fibre area (average area reduction > 30%, n = 5, P < 0.01). …”
Publicado 2022
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