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2841“…Stress-enhanced fear learning (SEFL) also uses an acute (single session) stressor for modeling PTSD in rodents. …”
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2842por Matos, Mariana R., Visser, Esther, Kramvis, Ioannis, van der Loo, Rolinka J., Gebuis, Titia, Zalm, Robbert, Rao-Ruiz, Priyanka, Mansvelder, Huibert D., Smit, August B., van den Oever, Michel C.“…Using a viral-based TRAP (targeted recombination in activated populations) approach, we studied whether consolidation of contextual fear memory by neurons in the medial prefrontal cortex (mPFC) is modulated by memory strength and CREB function. …”
Publicado 2019
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2843por Schipper, Pieter, Brivio, Paola, de Leest, David, Madder, Leonie, Asrar, Beenish, Rebuglio, Federica, Verheij, Michel M. M., Kozicz, Tamas, Riva, Marco A., Calabrese, Francesca, Henckens, Marloes J. A. G., Homberg, Judith R.“…To reveal whether and how 5-HTT gene variance affects fear-driven behavior in adolescence, we tested wildtype and serotonin transporter knockout (5-HTT(−/−)) rats of preadolescent, adolescent, and adult age for cued fear extinction and extinction recall. …”
Publicado 2019
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2844“…Previous studies have indicated that while a single weak fear conditioning trial is insufficient to support long-term memory (LTM), it can facilitate future learning such that another trial delivered within a protracted time window results in a robust memory. …”
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2845por Stubbendorff, Christine, Hale, Ed, Cassaday, Helen J., Bast, Tobias, Stevenson, Carl W.“…RATIONALE: Dopamine D1 receptor (D1R) signalling is involved in contextual fear conditioning. The D1R antagonist SCH23390 impairs the acquisition of contextual fear when administered systemically or infused locally into the dorsal hippocampus or basolateral amygdala. …”
Publicado 2019
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2846“…Recent work reveals that the extinction of conditioned fear depends upon the interval between conditioning and extinction. …”
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2847“…Using behavioral pharmacology and optogenetics, we investigated the role of OB ACh in a simple olfactory fear learning paradigm. We find that antagonizing muscarinic ACh receptors (mAChRs) in the OB during fear conditioning but not testing significantly reduces freezing to the conditioned odor, without altering olfactory abilities. …”
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2848“…Although it is an adaptive mechanism that danger usually elicits fear, it seems that fearful individuals overestimate the danger associated with their feared objects or situations. …”
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2849por Murkar, Anthony, Kent, Pam, Cayer, Christian, James, Jon, Durst, Tony, Merali, Zul“…Background: Δ9-Tetrahydrocannabinol (THC, a CB1 receptor agonist) and Cannabidiol (CBD, a non-competitive antagonist of endogenous CB1 and CB2 ligands) are two primary components of Cannabis species, and may modulate fear learning in mammals. The CB1 receptor is widely distributed throughout the cortex and some limbic regions typically associated with fear learning. …”
Publicado 2019
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2850por Kwon, Kyum-Yil, Park, Suyeon, Lee, Hye Mi, Park, Young-Min, Kim, Jinhee, Kim, Jaehwan, Koh, Seong-Beom“…METHODS: Demographic and clinical characteristics including the Fear of Falling Measure (FFM) were assessed in patients with de novo PD and in healthy subjects. …”
Publicado 2019
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2851por Kruisbrink, Marlot, Delbaere, Kim, Kempen, Gertrudis, Crutzen, Rik, Rixt Zijlstra, G A“…Fear of falling (FOF) is common among older people and can result in activity avoidance and decreased physical functioning. …”
Publicado 2019
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2852por Wannemueller, André, Gruszka, Piotr, Chwalek, Sarah, Fröhlich, Sonja, Mulders, Miriam, Schaumburg, Svenja, Schöttes, Johanna, Wiederhold, Sonja, Margraf, Jürgen“…OBJECTIVE: Exposure based large-group one-session treatments (LG-OSTs) proved feasible in different situational fears and showed promising short- and long-term outcomes. …”
Publicado 2019
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2853por Colucci, Paola, Mancini, Giulia Federica, Santori, Alessia, Zwergel, Clemens, Mai, Antonello, Trezza, Viviana, Roozendaal, Benno, Campolongo, Patrizia“…Here, we tested the effects induced by these two drugs on generalization of fear memory and their relative neurobiological underpinnings. …”
Publicado 2019
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2854por Murkar, Anthony, Cayer, Christian, James, Jon, Durst, Tony, Arnason, John T., Sanchez-Vindas, Pablos E., Otarola Rojas, M., Merali, Zul“…Furthermore, BA + BE, but not BA or BE alone, attenuated the reconsolidation of learned fear and exerted an anxiolytic-like effect on fear expression.…”
Publicado 2019
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2855por Rodríguez, María, Ceric, Francisco, Murgas, Paola, Harland, Bruce, Torrealba, Fernando, Contreras, Marco“…The insular cortex (IC), among other brain regions, becomes active when humans experience fear or anxiety. However, few experimental studies in rats have implicated the IC in threat responses. …”
Publicado 2020
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2856“…BACKGROUND: The aim of this study is to examine psychometric properties of the Turkish version of the fear of missing out scale (FoMOs) on three different study groups. …”
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2857por Asai, Hirotaka, Ohkawa, Noriaki, Saitoh, Yoshito, Ghandour, Khaled, Murayama, Emi, Nishizono, Hirofumi, Matsuo, Mina, Hirayama, Teruyoshi, Kaneko, Ryosuke, Muramatsu, Shin-ichi, Yagi, Takeshi, Inokuchi, Kaoru“…Furthermore, Pcdhβ-deficient mice exhibited reduced repetitive neuronal population activity during exploration of a novel context and were less able to discriminate contexts in a contextual fear conditioning paradigm. These results suggest that one function of Pcdhβs is to modulate neural ensemble activity in the hippocampus to promote context discrimination.…”
Publicado 2020
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2858“…Fear extinction is an active learning process whereby previously established conditioned responses to a conditioned stimulus are suppressed. …”
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2859“…Instructions given prior to extinction training facilitate the extinction of conditioned skin conductance (SCRs) and fear-potentiated startle responses (FPSs) and serve as laboratory models for cognitive interventions implemented in exposure-based treatments of pathological anxiety. …”
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2860