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921
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922
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923“…Longer development may influence the fitness of adults and have an impact on mating opportunities. …”
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924“…CONCLUSION: We present a graphical user interface for finding peptide mimetics that can be inserted into a protein or for fitting small molecules into a protein. Using SuperMimic, promising locations in proteins for the insertion of mimetics can be found quickly and conveniently.…”
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925
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926por Hayashi, Yuuki, Aita, Takuyo, Toyota, Hitoshi, Husimi, Yuzuru, Urabe, Itaru, Yomo, Tetsuya“…The fitness landscape in sequence space determines the process of biomolecular evolution. …”
Publicado 2006
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927“…Second, with the full consideration of back mutations, we study the equilibrium population distribution and the ancestor distribution in the genotype space as a function of error rate with and without lethality in a multiplicative fitness landscape. The results show that a high lethality of mutants actually introduces an error-threshold in a multiplicative fitness landscape in sharp contrast to the conclusion of Wilke. …”
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928“…CONCLUSIONS: Even the crudest transcriptional network is shown to substantially increase the fitness of the organism, and this effect persists even when the range of nutrient levels is kept very narrow. …”
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929
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930
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931“…BACKGROUND: According to sexual conflict theory, males can increase their own fitness by transferring substances during copulation that increase the short-term fecundity of their mating partners at the cost of the future life expectancy and re-mating capability of the latter. …”
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932“…Motivation: Modelers in Systems Biology need a flexible framework that allows them to easily create new dynamic models, investigate their properties and fit several experimental datasets simultaneously. …”
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933
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934
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935“…Understanding how beneficial mutations affect fitness is crucial to our understanding of adaptation by natural selection. …”
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936
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937“…Under such dynamics, recombination in the hosts may be advantageous because genetic shuffling can quickly produce disproportionately fit offspring (the Red Queen hypothesis). Previous models investigating these dynamics have assumed rather simple models of genetic interactions between hosts and parasites. …”
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938por Nager, Charles W., Richter, Holly E., Nygaard, Ingrid, Fidela Paraiso, Marie, Wu, Jennifer M., Kenton, Kimberly, Atnip, Shanna D., Spino, Cathie“…Hysterectomy, genital hiatus (GH), and GH/total vaginal length (TVL) ratios did not predict unsuccessful fitting (p > 0.05). However, mean TVL was greater in women successfully fitted (9.6 vs. 8.8 cm, p < 0.01). …”
Publicado 2009
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939“…SUMMARY: Changing medical professionalism to fit the changing health needs will not be easy. …”
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940“…We then use a Drosophila melanogaster model system to experimentally test the key prediction of this theoretical cost: that antagonistic male persistence is directed toward, and harms, intrinsically higher-fitness females more than it does intrinsically lower-fitness females. …”
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