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  1. 1981
    “…RESULTS: Among 12,585 patients with AF, 7.8% were categorized as fit, 31.5% as mildly frail, 34.8% as moderately frail, and 25.9% as severely frail. …”
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    Frailty and subsequent adverse outcomes in older patients with atrial fibrillation treated with oral anticoagulants: The Shizuoka study
  2. 1982
    “…After adjustment for other factors, compared with participants who were physically robust with no SMC, participants who reported either SMC alone (HR = 0.88, 95% CI = 0.60–1.27) or were frail/pre-frail alone (HR = 1.32, 95% CI = 0.90–1.92) had no significantly increased mortality risk. …”
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    Joint predictability of physical frailty/pre-frailty and subjective memory complaints on mortality risk among cognitively unimpaired older adults
  3. 1983
    “…Propensity score matching identified 289 frail patients and 281 non-frail patients. Mann-Whitney U testing was performed and receiver operating characteristic (ROC) curves were created, following the creation of logistic regression models for predicting discharge disposition. …”
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    Association between frailty status and complications in patients undergoing surgical excision of malignant esophageal neoplasms
  4. 1984
    “…CONCLUSIONS: ML proved useful in identifying individuals who became frail over time, and this result was made possible by balancing the data set. …”
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    Machine Learning Models to Predict Future Frailty in Community-Dwelling Middle-Aged and Older Adults: The ELSA Cohort Study
  5. 1985
    “…The incidence of severe pulmonary toxicities in the frail elderly subgroup was significantly higher than that in the fit elderly subgroup. …”
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    Influence of Comorbidities on the Efficacy of Radiotherapy with or without Chemotherapy in Elderly Stage III Non-small Cell Lung Cancer Patients
  6. 1986
    “…INTERVENTION: The Frail Elderly Project, a Dutch quality improvement program, aims to decrease adverse events in frail older hospitalized people by implementing screening instruments and interventions targeting delirium, falls, malnutrition and physical impairment. …”
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    What impedes and what facilitates a quality improvement project for older hospitalized patients?
  7. 1987
    “…All scales had low predictability for postoperative complications, but for length of mechanical ventilation we obtained positive correlations with EuroScore II, Edmonton Frail Scale and Clinical Frailty Scale. EuroScore II can also predict the length of stay in the intensive care unit. …”
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    Are frailty scales better than anesthesia or surgical scales to determine risk in cardiac surgery?
  8. 1988
    “…CONCLUSION: Community-based structured FPT is safe and feasible for frail older adults, with the potential to improve function and reverse frailty status.…”
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    Feasibility of a community-based Functional Power Training program for older adults
  9. 1989
    “…A total of 17.5% of the patients were non-frail, 73.7% were pre-frail and only 8.7% were frail. …”
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    Physical frailty characteristics have a differential impact on symptoms as measured by the CAT score: an observational study
  10. 1990
    “…The patients were categorized as nonfrail (n=140), prefrail (n=81), and frail (n=159) by the criteria of frailty phenotype. …”
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    Relationship between nutritional status and frailty in hospitalized older patients
  11. 1991
    “…Based upon the CGA, 58% were frail and the most accurate instrument for separating frail from non-frail was the PRISMA-7 (AUC 0.88; 95% CI:0.83–0.93) followed by the CFS (AUC 0.83; 95% CI:0.77–0.88), and the ISAR (AUC 0.78; 95% CI:0.71–0.84). …”
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    Comparison of Frailty Screening Instruments in the Emergency Department
  12. 1992
    “…Methods: Semi-structured focus groups were conducted with five stakeholder groups (frail/pre-frail and robust older adults, health and social care professionals and family caregivers) in Poland (n = 44). …”
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    A qualitative study examining everyday frailty management strategies adopted by Polish stakeholders
  13. 1993
    “…INTRODUCTION: Individuals who have been identified as frail have an increased state of vulnerability, often leading to adverse health events, increased health spending, and potentially detrimental outcomes. …”
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    Developing and Validating a Primary Care EMR-based Frailty Definition using Machine Learning
  14. 1994
    “…RESULTS: A total of 353 patients with CKD were recruited with 225 (64%) participants categorised as frail. Frail participants reported more symptoms, had higher symptom scores and worse HRQOL scores. …”
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    Symptom-burden in people living with frailty and chronic kidney disease
  15. 1995
    “…The difference in diversity score between frail and non frail were examined by t-test. Logistic regression analysis with covariates, age, sex, economic status, living alone, BMI, Mini-Mental State Examination, and IADL was adopted to find association between activity diversity score and presence of frailty. …”
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    Association Between Activity Diversity and Frailty in Community-Dwelling Older Japanese: A Cross-Sectional Study
  16. 1996
    “…Results: 214 patients (94 women) were included of whom 142 (66.4%) were frail with a median Clinical Frailty Scale (CFS) score of 6. …”
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    Clinical Features, Inpatient Trajectories and Frailty in Older Inpatients with COVID-19: A Retrospective Observational Study
  17. 1997
    “…RESULTS: Of 69 consecutive outpatients with asthma, 38 (55.1%), 21 (30.4%), and 10 (14.5%) were classified as robust, pre‐frail, and frail, respectively. Eight out of 52 patients with asthma in the elderly (AIE) (>65 years old) (15.4%) were considered as being frail. …”
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    Are frailty and patient‐reported outcomes independent in subjects with asthma? A cross‐sectional observational study
  18. 1998
    “…In the 372 patients analysed, the median age was 77 years, 154 (41.4%) were women, 44 (11.8%) were COVID-19-positive, and 125 (33.6%) were frail. The worst outcome was seen in frail COVID-19-patients with six (66.7%) adverse outcomes. …”
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    Association of Frailty with Adverse Outcomes in Patients with Suspected COVID-19 Infection
  19. 1999
    “…Patients in two studies received chemotherapy, two studies radiotherapy, two studies surgery, one study not reported. Compared to non-frail patients, frail patients had a higher risk of overall mortality [Hazard Ratio (HR) = 1.57, 95% confidence interval (CI), 1.32–1.87], and therapeutic toxicity [Odds Ratio (OR) = 2.60, 95% CI, 0.82–8.24]. …”
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    Impacts of Frailty on Prognosis in Lung Cancer Patients: A Systematic Review and Meta-Analysis
  20. 2000
    “…In multivariable analysis, prefrail (HR 1·7, 1·1–2·5) and frail patients (HR 2·9, 1·6–5·5), those with higher DIPSS score (HR 2·5, 1·6–3·9) and transfusion dependency (HR 1·9, 1·3–2·9) had shorter OS. …”
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    Association of frailty with clinical outcomes in myelofibrosis: a retrospective cohort study
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