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  1. 2441
    “…Five hundred and sixty-nine participants attended phase 1 screening. Pre-frail or frail ambulant participants or those with underlying cognitive impairment were invited to participate in phase 2 screening. …”
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    Community-Based Peer-Led Intervention for Healthy Ageing and Evaluation of the ‘HAPPY’ Program
  2. 2442
    “…Hospital mortality was 9.8% among frail patients and 1.0% among nonfrail patients (adjusted hazard ratio 3.84, 95% CI 0.90–16.34). …”
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    Association between preoperative frailty and outcomes among adults undergoing cardiac surgery: a prospective cohort study
  3. 2443
    “…RESULTS: We identified 26 studies (24 RCTs [1 of which did not have any relevant outcomes for extraction] and 2 observational studies) involving 8022 prefrail or frail older adults. Nine studies had low risk of bias, 2 had high risk of bias, and for 13 the risk of bias was unclear. …”
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    Effectiveness of physical activity interventions in older adults with frailty or prefrailty: a systematic review and meta-analysis
  4. 2444
    “…We compared Chinese Mini Mental State Examination (CMMSE) and Chinese Frontal Assessment Battery (FAB) scores across the socially non-frail, socially pre-frail and socially frail. Participants were further recategorized into three subgroups (neither, either or both) based on presence of social frailty and cognitive impairment. …”
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    Social Frailty and Executive Function: Association with Geriatric Syndromes, Life Space and Quality of Life in Healthy Community-Dwelling Older Adults
  5. 2445
    “…RESULTS: 809 participants (67.6+6.8 years) had complete data for all 5 IC domains. 489 (60.4%) participants were robust but only 213 (26.3%) had no decline in any IC domain. Pre-frail and frail participants were more likely to exhibit decline in all 5 IC domains (p<0.05), with decremental composite IC [9 (8–9), 8 (6–9), 5.5 (4–7.5), p<0.001] across robust, prefrail and frail. …”
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    Association of Intrinsic Capacity with Frailty, Physical Fitness and Adverse Health Outcomes in Community-Dwelling Older Adults
  6. 2446
    “…Prefrailty was operationalized as (i) FRAIL score 1–2 or (ii) 0 positive response on FRAIL but with weak grip strength or slow gait speed based on the Asian Working Group for Sarcopenia cut-offs. …”
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    Intrinsic capacity rather than intervention exposure influences reversal to robustness among prefrail community-dwelling older adults: A non-randomized controlled study of a multidomain exercise and nutrition intervention
  7. 2447
    “…Using the Johns Hopkins indicator, 30.3% of patients with sigmoid volvulus and 15.9% of those with cecal volvulus were considered frail. After adjustment, frail patients had higher risk of mortality compared to non-frail in both sigmoid (10.6% [95% CI 9.47–11.7] vs 5.7% [95% CI 5.2–6.2]) and cecal (10.4% [95% CI 9.2–11.6] vs 3.5% [95% CI 3.2–3.8]) volvulus cohorts. …”
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    Association of frailty with outcomes of resection for colonic volvulus: A national analysis
  8. 2448
    “…The aim was to study non-specific signs and symptoms and fever temperature for early detection of ongoing infection in frail elderly, and how these correlates to provide the instrument, the Early Detection Infection Scale (EDIS), which is used to assess changes in health condition in frail elderly. …”
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    The value of fever assessment in addition to the Early Detection Infection Scale (EDIS). A validation study in nursing home residents in Sweden
  9. 2449
    “…The main outcome was cognitive frailty at 24 months, expressed as an ordinal variable based on the six combinations of its two components: frailty (non-frail, pre-frail, and frail) and mild cognitive impairment (yes, no). …”
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    Effect of 24-month physical activity on cognitive frailty and the role of inflammation: the LIFE randomized clinical trial
  10. 2450
    “…RESULTS: Forty (20%) patients were frail (CFS ≥5). These individuals had greater comorbidity, functional impairment and a higher risk of death at 12 months (49% vs. 9% in non-frail patients, p < 0.001). …”
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    Frailty assessment and risk prediction by GRACE score in older patients with acute myocardial infarction
  11. 2451
    por Sha, Sha, Xu, Yuebin, Chen, Lin
    Publicado 2020
    “…CONCLUSION: Older people with a high level of loneliness tend to be frail in the future, and greater loneliness is related to an increased risk of worsening frailty and remaining frail. …”
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    Loneliness as a risk factor for frailty transition among older Chinese people
  12. 2452
    “…Mortality increased with frailty (16.7% in pre-frail, 22.2% in moderately frail, and 50.0% in frail; P < .001). …”
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    Risk Factors, Presentation, and Course of Coronavirus Disease 2019 in a Large, Academic Long-Term Care Facility
  13. 2453
    “…BACKGROUND: Elderly, frail patients are often excluded from clinical trials so there is lack of data regarding optimal management when they present with symptomatic coronary artery disease (CAD). …”
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    Prospective cohort study of elderly patients with coronary artery disease: impact of frailty on quality of life and outcome
  14. 2454
    “…Moreover, the study will substantially contribute to new information on the predictors of aging, senescence, and senility, particularly in frail and pre-frail outpatients from an LMIC city.…”
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    Prospective GERiatric Observational (ProGERO) study: cohort design and preliminary results
  15. 2455
    “…Cox regression analyses showed that each additional deficit of the Frail-VIG index increased the risk of death by 61.5%, 30.1%, 29.6% and 12.9% in people with dementia, organ failure, multimorbidity and cancer, respectively (p<0.01 for all the coefficients). …”
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    Frailty degree and illness trajectories in older people towards the end-of-life: a prospective observational study
  16. 2456
    “…BACKGROUND: Many assessment tools have been used to identify frail surgical patients. This study was designed to explore the prediction value of the frailty index (FI) for postoperative morbidity in older patients undergoing elective gastrointestinal surgery. …”
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    Frailty index is useful for predicting postoperative morbidity in older patients undergoing gastrointestinal surgery: a prospective cohort study
  17. 2457
    “…According to the results of a self-report frailty questionnaire, participants were retrospectively split up into three groups, F (frail, n = 43), P (pre-frail, n = 33), and R (robust, n = 12). …”
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    The relationship between self-reported physical frailty and sensor-based physical activity measures in older adults – a multicentric cross-sectional study
  18. 2458
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    $\beta$-decay studies far from stability with the total absorption technique: the case of $^{76}$Sr
  19. 2459
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    Evaluation framework for healthcare integration pilots in the Basque Country/Marco evaluativo de las experiencias de integración asistencial en el País Vasco
  20. 2460
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    Malignant coronary vasospasm refractory to nitrates: using clevidipine as an emergent coronary vasodilator
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