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  1. 2861
    “…RESULTS: At baseline, 7.5% (n = 86) of participants were frail. During follow-up, 38 participants died. Mortality rate was significantly higher among frail participants: 25.7/1000 person-years of follow-up (PYFU) (95% confidence interval [CI], 14.2–46.4) compared with prefrail (7.2/1000 PYFU [95% CI, 4.7–11.2]) and robust (2.3/1000 PYFU [95% CI, 1.1–4.9]). …”
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    Frailty Is Associated With Mortality and Incident Comorbidity Among Middle-Aged Human Immunodeficiency Virus (HIV)–Positive and HIV-Negative Participants
  2. 2862
    “…Although omission of surgery can be considered in frail older patients, it may lead to inferior outcomes in non‐frail patients. …”
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    Effect of omission of surgery on survival in patients aged 80 years and older with early‐stage hormone receptor‐positive breast cancer
  3. 2863
    “…DSDRS was higher among frail, pre-frail, and subjects with limited ADL and IADL (p < 0.001). …”
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    The type 2 diabetes-specific dementia risk score (DSDRS) is associated with frailty, cognitive and functional status amongst Mexican community-dwelling older adults
  4. 2864
    “…RESULTS: The CC levels were significantly lower in the frail than the non-frail (26.7 ± 4.0 vs. 31.2 ± 4.0, P < 0.001). …”
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    Low calf circumference is associated with frailty in diabetic adults aged over 80 years
  5. 2865
    “…The presence of frailty was associated with a higher severity of complications (OR: 2.07; 95% CI: 1.40 to 3.05). Frail patients were more likely to develop in-hospital pneumonia than non-frail patients (OR: 2.08; 95% CI: 1.28 to 3.39). …”
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    The association between preoperative modified frailty index and postoperative complications in Chinese elderly patients with hip fractures
  6. 2866
    “…CONCLUSIONS: These findings suggest that people with older subjective age are more likely to be pre-frail/frail. Subjective age could be used as a quick and economical screening for those who are potentially frailty or at risk for frailty.…”
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    Bidirectional relationship between subjective age and frailty: a prospective cohort study
  7. 2867
    “…We aimed to evaluate frailty-related alterations of the intestinal permeability and profile fecal microbiota of healthy and frail older adults to identify microbial biomarkers of this syndrome. …”
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    Altered Fecal Microbiota Composition in Older Adults With Frailty
  8. 2868
    “…Non-frail patients, however, with systolic BP levels <140 mmHg had a better prognosis. …”
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    Blood pressure, frailty status, and all-cause mortality in elderly hypertensives; The Nambu Cohort Study
  9. 2869
    “…Patients who were very old, multimorbid, frail, and had severe COVID-19 were more likely to receive palliative care. …”
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    Palliative care in Hospitalized Middle-Aged and Older Adults With COVID-19
  10. 2870
    “…Due to the risk of perioperative morbidity and mortality, alternative nonoperative treatment options have been explored in elderly and frail patients who are clinically inoperable or refuse surgery. …”
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    Image-guided high-dose-rate brachytherapy for rectal cancer: technical note and first clinical experience on an organ-preserving approach
  11. 2871
    “…METHODS: The feasibility of several frailty screening instruments (PRISMA-7 [P7], Edmonton Frail Scale [EFS], FRAIL Questionnaire [FQ], Gait Speed Test [GST], Groningen Frailty Indicator [GFI], Kihon Checklist [KC] and Timed Up and Go [TUG]) to 43 Australian GPs and PNs was assessed. …”
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    Practitioner perceptions of the feasibility of common frailty screening instruments within general practice settings: a mixed methods study
  12. 2872
    “…Furthermore, the mortality rate in frail patients was significantly elevated to 17%, compared to less than 1% in non-frail patients (p = 0.018). …”
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    Frailty in elderly patients with acute appendicitis
  13. 2873
    “…PURPOSE: Despite being among those most in need of protection, frail older adults are often not well represented in clinical trials. …”
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    An Easy-to-Implement Clinical-Trial Frailty Index Based on Accumulation of Deficits: Validation in Zoster Vaccine Clinical Trials
  14. 2874
    “…Large differences in mortality rates between fit and frail patients suggest that the CFS may be a useful complementary triage tool for ICU admission in dialysis patients with COVID-19.…”
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    The Clinical Frailty Scale as a triage tool for ICU admission of dialysis patients with COVID-19: an ERACODA analysis
  15. 2875
    “…RESULTS: Multivariate regression analysis showed that with all 3 frailty scores, increasing frailty tiers resulted in worse postoperative outcomes, and patients identified as frail and severely frail using RAI-Rev and RAI-A had the highest odds of poor outcomes. …”
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    Risk Analysis Index and Its Recalibrated Version Predict Postoperative Outcomes Better Than 5-Factor Modified Frailty Index in Traumatic Spinal Injury
  16. 2876
    “…We selected 30 health-related variables, computed the Rockwood FI, and applied standard thresholds for robust (FI < 0.1), pre-frail (0.1 ≤ FI < 0.21), and frail (FI ≥ 0.21). RESULTS: Complete data for the FI was available for 660 older adults. …”
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    Prevalence and association of frailty with SARS-CoV-2 infection in older adults in Southern Switzerland—Findings from the Corona Immunitas Ticino Study
  17. 2877
    “…In multivariable analyses, only the G8 Score retained independent significance as a prognostic factor for disease-specific survival (DSS) (HR:4.58; 95% CI [1.35–15.51]) and overall survival (OS) (HR:2.89; 95% CI [1.31–6.39]. 92 patients (61.3%) were classified as G8-non-frail with a significantly increased DSS and OS rate compared to the 58 G8-frail patients (DSS:93.8% vs. 60.8%; p < 0.001 and OS:88.2% vs. 49.7%; p < 0.001; respectively). …”
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    The preoperative G8 geriatric screening tool independently predicts survival in older patients with endometrial cancer: results of a retrospective single-institution cohort study
  18. 2878
    “…METHODS: This study assessed the preoperative frailty according to the Fried’s frailty phenotype, and included 150 frail and 150 non-frail elderly patients (≥ 65 y) who underwent bypass surgery. …”
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    Preoperative frailty assessment could be a predictive factor for the prognosis of elderly patients undergoing coronary artery bypass grafting: a retrospective case-control study
  19. 2879
    “…Moreover, the cardiorenal nexus encompasses a bidirectional relationship that worsens prognosis and may complicate pharmacological management in often elderly and frail patients. Therefore, a more cohesive multidisciplinary team approach aiming to provide holistic, coordinated and specialized care would be a positive shift towards improving patient outcomes and optimizing healthcare resources. …”
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    Practical approaches to building up a cardiorenal clinic
  20. 2880
    “…We have described the case of a frail patient with home oxygen-dependent chronic obstructive pulmonary disease and prior free vein circumflex coronary artery bypass who had presented with a ruptured type A aortic dissection and was deemed too high risk for open surgery. …”
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    Ascending thoracic endovascular aortic repair with chimney stent graft to free vein coronary bypass for ruptured type A aortic dissection
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