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  1. 2941
    “…At baseline, 101 (92.7%) were functionally independent, of whom seven (6.9%) had loss of independence at 1 year; 28 (25.7%) and 81 (74.3%) patients were frail and non-frail (by mFFC) respectively. On univariate analysis, age, Charlson Comorbidity Index and frailty (mFFC) (univariate OR 13.00, 95% CI 2.21–76.63, p < 0.01) were significantly associated with loss of functional independence at 1 year. …”
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    Frailty and functional decline after emergency abdominal surgery in the elderly: a prospective cohort study
  2. 2942
    “…It remains challenging to distinguish fit elderly patients who can endure standard therapy from frail patients who may benefit from an adapted treatment strategy. …”
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    GERiatric Screening in the treatment of elderly patients with Ovarian Carcinoma (GERSOC): study protocol for a pragmatic, cluster randomised controlled trial
  3. 2943
    “…RESULTS: Frailty was present in 43.9% of the participants. Frail inpatients showed higher waist circumference, body fat mass and percent body fat, non-frail inpatients showed greater upper arm circumference, calf circumference, skeletal muscle mass, total body water, fat-free mass and basal metabolic rate. …”
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    Association Between Body Composition and Frailty in Elder Inpatients
  4. 2944
    “…Results: Our sample included 2973 individuals (1503 women), mean age 54 years. 1207 (43%) were categorised as non-frail, 1324 (44%) as prefrail, 212 (7%) as frail, and 167 (6%) were unable to complete all five frailty score components. …”
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    Frailty and physical performance in the context of extreme poverty: a population-based study of older adults in rural Burkina Faso
  5. 2945
    “…RESULTS: 3500 cases were included, of which 17% were considered frail and 24% were infratentorial. The most common 30-day medical complications were pneumonia (4%), venous thromboembolism (VTE;3%), and urinary tract infections (2%). …”
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    SURG-09. SURGICAL AND PERI-OPERATIVE CONSIDERATIONS FOR BRAIN METASTASES: A NATIONWIDE ANALYSIS
  6. 2946
    “…Before ICU admission, 13% of all patients was frail, 65% suffered from fatigue, 28% and 26% from symptoms of anxiety and depression, respectively, and 6% from cognitive problems. …”
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    Physical, Mental, and Cognitive Health Status of ICU Survivors Before ICU Admission: A Cohort Study
  7. 2947
    “…A higher proportion of patients who died were frail (group 2: 63 vs group 1: 37%, p < 0.001), with a higher prevalence of cardiovascular disease (group 2: 58 vs group 1: 33%, p < 0.001) and respiratory diseases (group 2: 38 vs group 1: 25%, p = 0.03). …”
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    Older age and frailty are the chief predictors of mortality in COVID-19 patients admitted to an acute medical unit in a secondary care setting- a cohort study
  8. 2948
    “…Probable infected patients were older, frail, and with a worse functional situation than those without COVID-19. …”
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    COVID-19 outbreak in long-term care facilities from Spain. Many lessons to learn
  9. 2949
    “…RESULTS: Between the pre- and post-COVID-19 assessments, we found a 19% greater deterioration in handgrip, a 22% greater decrease in walking speed, and a 21% greater increase in Frail-NH scores in cases compared with controls. …”
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    Increase in Frailty in Nursing Home Survivors of Coronavirus Disease 2019: Comparison With Noninfected Residents
  10. 2950
    “…However, many medical centers employ the cementless technique for the frail elderly population because it is faster and has lower cardiovascular risks and perioperative mortality. …”
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    Cementless Hemiarthroplasty for Intracapsular Femoral Neck Fractures in the Octa- and Nonagenarians
  11. 2951
    “…RESULTS: We analysed data from 300 participants (mean age 74 years; 86 [29%] women). 148 (49%) were pre-frail, 86 (29%) were frail. In multivariable cross-sectional baseline analyses, only age and BMI were significantly associated with baseline short physical performance battery; age, sex, body mass index, NT-pro-BNP and 25-hydroxyvitamin D were significantly associated with baseline six-minute walk distance. …”
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    Associations between frailty, physical performance, and renal biomarkers in older people with advanced chronic kidney disease
  12. 2952
    “…We demonstrate the potential for D(3)-Cr to be used alongside D(2)O and D(3)-3MH for concurrent measurement of muscle mass, MPS, and MPB using a minimally invasive design, applicable for clinical and frail populations.…”
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    Combined in vivo muscle mass, muscle protein synthesis and muscle protein breakdown measurement: a ‘Combined Oral Stable Isotope Assessment of Muscle (COSIAM)’ approach
  13. 2953
    “…METHODS: in the British Regional Heart Study, 1,225 robust or pre-frail men aged 71–92 years underwent a baseline examination, with questionnaire-based frailty assessment after 3 years. …”
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    Associations between inflammation, cardiovascular biomarkers and incident frailty: the British Regional Heart Study
  14. 2954
    “…We calculated the proportion of primary analyses with robust and frail conclusions, quantified by our proposed metric, the robustness index (RI), and current sensitivity analysis standards. …”
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    How robust are findings of pairwise and network meta-analysis in the presence of missing participant outcome data?
  15. 2955
    “…The main outcomes were mortality, length of hospital stay (LOH) and intensive care unit (ICU) admission in frail and non-frail COVID-19 patients. Frailty was also compared in survivors and non-survivors. …”
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    Clinical Frailty Scale (CFS) indicated frailty is associated with increased in-hospital and 30-day mortality in COVID-19 patients: a systematic review and meta-analysis
  16. 2956
    “…More controlled studies are needed on alternative routes for opioid administration and pre-hospital pain management for potentially more frail patient subgroups. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40122-021-00346-w.…”
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    Opioids for Treatment of Pre-hospital Acute Pain: A Systematic Review
  17. 2957
    “…Among candidates (mean age=55 years), 41% were female, 46% were Black, and 19% were frail. After controlling for mean frailty level, females were more likely to endorse exhaustion (OR=1.20,p=0.003), but less likely to endorse low activity (OR=0.83,p=0.01). …”
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    Measurement Disparities in Frailty Among Kidney Transplant Patients: Impact of Differential Item Functioning
  18. 2958
    “…As transitions of care for frail people are considered risky, securing the quality and safety of these transitions is of great international interest. …”
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    Balancing standardisation and individualisation in transitional care pathways: a meta-ethnography of the perspectives of older patients, informal caregivers and healthcare professionals
  19. 2959
    “…LFI was calculated using the online LFI calculator, available at http://liverfrailtyindex.ucsf.edu and classified as ‘Robust’ if LFI <3.2, ‘Prefrail’ LFI between 3.2 and 4.4, and ‘Frail’ as LFI ≥4.5. Correlation of frailty with MELD, MELD-Na and CTP Scores was done. …”
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    Assessment of frailty in cirrhosis using bedside measures and its correlation with Child-Turcotte-Pugh, MELD & MELD-Na Scores
  20. 2960
    “…DISCUSSION: The GSH sites share a common goal to increase the accessibility of essential services to frail older adults and provide comprehensive care. …”
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    Protocol for a mixed-methods and multi-site assessment of the implementation process and outcomes of a new community-based frailty programme
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