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  1. 1421
    “…Frailty incidence increased over time: baseline (3% frail, 37% pre-frail); 5 years (10% frail, 40% pre-frail). …”
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    Factors associated with change in frailty scores and long-term outcomes in older adults with coronary artery disease
  2. 1422
    “…RESULTS: Among 4200 participants aged 65–70 years (58% female) at baseline, 70% were non-frail, 27% pre-frail and 2.0% frail. Over an average follow-up of 5.8 years, 2422 transitions were observed, with 1575 (65%) forward and 847 (35%) backward. …”
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    How blood pressure predicts frailty transitions in older adults in a population-based cohort study: a multi-state transition model
  3. 1423
    “…VA-FI identified five groups: robust (≤0.1), prefrail (0.1–0.2), frail (0.2–0.3), moderately frail (0.3–0.4), and severely frail (>0.4). …”
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    REVISITING ELECTRONIC FRAILTY INDEX BY ADDING A LAB-BASED MARKER OF NUTRITION: A HEART FAILURE COHORT
  4. 1424
    “…Among 1,724 participants with hearing loss, compared to hearing aid users (N = 522), nonusers had greater odds of being frail (OR = 2.54 [1.54–4.18]) and pre-frail (OR = 1.51 [1.05–2.17]) versus robust, and frail versus pre-frail (OR = 1.68 [1.04–2.72]). …”
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    The association of hearing loss with frailty among community-dwelling older adults: findings from the National Health and Aging Trends Study
  5. 1425
    “…RESULTS: Overall, 2953 participants were included: 150 (5.1%) were frail OAB, 416 (14.1%) non-frail OAB, 287 (9.7%) frail non-OAB, and 2100 (71.1%) non-frail non-OAB. …”
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    A non-interventional cross-sectional re-contact study investigating the relationship between overactive bladder and frailty in older adults in Japan
  6. 1426
    “…Therefore, our aim is to explore (bio)marker trajectories in adults who became cognitively frail compared to age- and sex-matched controls who did not become cognitively frail over a 15 year follow-up. …”
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    Trajectories of (Bio)markers During the Development of Cognitive Frailty in the Doetinchem Cohort Study
  7. 1427
    “…APACHE-II and SOFA scores were 22.1 ± 7.0 and 7.2 ± 3.29, significantly higher in frail patients, respectively. There was a trend towards higher requirement for organ supports in frail patients. …”
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    Prevalence of Frailty in ICU and its Impact on Patients’ Outcomes
  8. 1428
    “…Cox regression analyses were used to compare subsequent all-cause mortality for non-frail (score 0), pre-frail (score 1–2) and frail participants (score 3+). …”
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    Prevalence and correlates of frailty in an older rural African population: findings from the HAALSI cohort study
  9. 1429
    por Luo, Jia, Tang, Wen, Sun, Ying, Jiang, Chunyan
    Publicado 2020
    “…Frail participants were significantly more likely to have severe CAP (SCAP) than non-frail counterparts (28.65% vs 9.41%, p<0.001). …”
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    Impact of frailty on 30-day and 1-year mortality in hospitalised elderly patients with community-acquired pneumonia: a prospective observational study
  10. 1430
    “…The 920 patients were divided into the frail patient group (N = 221) and non-frail patient group (N = 699). …”
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    Association between frailty and mortality among patients with accidental hypothermia: a nationwide observational study in Japan
  11. 1431
    “…Participants were categorized as non-frail (FI≤ 0.08), pre-frail (FI=0.08–0.25) or frail (FI≥ 0.25) for stratified analyses. …”
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    5. How Does Frailty Impact the Efficacy, Reactogenicity, Immunogenicity and Safety of the Adjuvanted Recombinant Zoster Vaccine? A Secondary Analysis of the ZOE-50 and ZOE-70 Studies
  12. 1432
    “…INTERPRETATION: Compared with non-frail patients (pre-frail and robust), those with frailty had lower levels of vaccination protection against COVID-19-associated hospitalisation and all-cause death. …”
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    COVID-19 mRNA vaccine effectiveness against hospitalisation and death in veterans according to frailty status during the SARS-CoV-2 delta (B.1.617.2) variant surge in the USA: a retrospective cohort study
  13. 1433
    “…Frailty was measured using a previously validated Frailty Index (FI) of health and functional deficits; baseline frailty was categorized using published cutoffs (0-.1 non-frail, >.1-.21 pre-frail, >.21-.45 frail, >.45 most frail). …”
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    Frailty Hinders Recovery From Acute Respiratory Illness in Older Adults
  14. 1434
    “…Mean (SD) healthcare cost in the study period was €1420.19 for robust subjects, €2845.51 for pre-frail subjects, €4200.05 for frail subjects, and €5610.73 for very frail subjects. …”
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    Relationship of frailty status with health resource use and healthcare costs in the population aged 65 and over in Catalonia
  15. 1435
    “…Non-frail mice lived to 29 months whereas frail/pre-frail mice lived only to 26 months (p = .04). …”
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    Identifying Characteristics of Frailty in Female Mice Using a Phenotype Assessment Tool
  16. 1436
    “…We conducted logistic regression analysis to calculate the odds ratios of using each travel mode by frailty status stratified by locality. Relative to non-frail participants, frail participants were less likely to walk and drive a car in all three areas. …”
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    Frailty Status and Transport Disadvantage: Comparison of Older Adults’ Travel Behaviours between Metropolitan, Suburban, and Rural Areas of Japan
  17. 1437
    “…Conversely, frail participants showed elevated gene expression in IL-8 signaling, T-cell exhaustion, and oxidative stress pathways compared with non-frail participants. …”
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    The impact of physical frailty on the response to inactivated influenza vaccine in older adults
  18. 1438
    “…In this article we suggest an approach based on a multidimensional, interdisciplinary evaluation aimed at the early identification and management of frail CKD patients independent of the clinical setting of admission; however, more important than the method used is the need to identify and follow-up on frail CKD patients.…”
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    „Frailty“ bei nephrologischen Erkrankungen
  19. 1439
    “…Kaplan–Meier curves showed a significantly higher incidence of MACE in the frail group compared to those in the non-frail group (Log-rank p < 0.001). …”
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    Association of preoperative clinical frailty and clinical outcomes in elderly patients with stable coronary artery disease after percutaneous coronary intervention
  20. 1440
    “…We aimed to evaluate the effectiveness of a multimodal intervention on functional performance in frail and pre‐frail participants aged ≥70 years with type 2 diabetes mellitus. …”
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    Effectiveness of a multimodal intervention in functionally impaired older people with type 2 diabetes mellitus
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