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  1. 484001
    “…This pilot trial indicates the benefits of providing free WW vouchers for weight loss maintenance and improving QoL but provided no evidence that including additional dietetic support would add any extra value. …”
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    Pilot randomised controlled trial of Weight Watchers® referral with or without dietitian-led group support for weight loss in women treated for breast cancer: the BRIGHT (BReast cancer weIGHT loss) trial
  2. 484002
    “…Here, cerebral microvascular endothelial cells (bEnd.3) were incubated in glucose-free Dulbecco’s modified Eagle’s medium containing 95% N(2)/5% CO(2) for 6 hours, followed by high-glucose medium containing 95% O(2) and 5% CO(2) for 18 hours to establish an oxygen-glucose deprivation/reperfusion model. …”
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    Shuxuetong injection protects cerebral microvascular endothelial cells against oxygen-glucose deprivation reperfusion
  3. 484003
    “…The overall survival rate and disease-free survival time of patients with high expression of FBXO22 were significantly shorter than those of patients with low expression of FBXO22. …”
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    FBXO22 promotes the development of hepatocellular carcinoma by regulating the ubiquitination and degradation of p21
  4. 484004
    “…ABBREVIATIONS: ABS: Applied Biosystem(®)TaqMan real-time PCR assay, CI: Confidence interval, CLD: Chronic liver disease, CLIA: Chemi-luminescence immunoassay, COBAS: Roche Cobas(®) Ampliprep/ TaqMan assay, DAA: Direct Acting Anti-Viral drugs, EIA: Enzyme immunoassay, HBV: Hepatitis B virus, HCV: Hepatitis C virus, HFPM: Hepatitis Free Pahang Malaysia, LOA: Limits of agreement, LOD: Limit of detection, MOH: Ministry of Health, Malaysia, NAT: Nucleic Acid Tests, POCT: Point of Care Tests, SD: Standard deviation, WHO: World Health Organization How to cite this article: Radzi AHM, Tan SS, Mohamed R, Jaya F, Senamjit K, Aun AC, Kutty GA, Wong HS, Abdullah R, Seman MR, Mahtab MA, Morad Z, Lim TO. …”
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    Hepatitis Screening and Treatment Campaign in Malaysia-Validation of Low-cost Point of Care Screening Tests and Nucleic Acid Tests for Hepatitis B and C
  5. 484005
    “…In agreement with the experimental studies, a series of conserved residues viz., Gln52, Ser53, Ser54, Leu68, Pro69, Gly71, Gly73, Thr76, Asp151, Gly154, Thr220, Lys221, Val251, Cys253, Arg254, and Gly255 were computed to be indispensable for tight anchoring of GTP within binding cavity of G-domain. The binding free energy calculation study depicted that the van der Waals and electrostatic terms contributs significantly to molecular recognition of GTP. …”
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    Molecular cloning, GTP recognition mechanism and tissue-specific expression profiling of myxovirus resistance (Mx) protein in Labeo rohita (Hamilton) after Poly I:C induction
  6. 484006
    “…Background: The Dietary Approaches to Stop Hypertension (DASH) dietary pattern, which emphasizes fruit, vegetables, fat-free/low-fat dairy, whole grains, nuts and legumes, and limits saturated fat, cholesterol, red and processed meats, sweets, added sugars, salt and sugar-sweetened beverages, is widely recommended by international diabetes and heart association guidelines. …”
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    DASH Dietary Pattern and Cardiometabolic Outcomes: An Umbrella Review of Systematic Reviews and Meta-Analyses
  7. 484007
    “…We chose overall survival (OS) as the primary observation endpoint and progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and safety as the secondary observation endpoints. …”
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    Real-world evidenceand clinical observations of the treatment of advanced non-small cell lung cancer with PD-1/PD-L1 inhibitors
  8. 484008
    por Shewade, Hemant Deepak, Gupta, Vivek, Satyanarayana, Srinath, Pandey, Prabhat, Bajpai, U. N., Tripathy, Jaya Prasad, Kathirvel, Soundappan, Pandurangan, Sripriya, Mohanty, Subrat, Ghule, Vaibhav Haribhau, Sagili, Karuna D., Prasad, Banuru Muralidhara, Nath, Sudhi, Singh, Priyanka, Singh, Kamlesh, Singh, Ramesh, Jayaraman, Gurukartick, Rajeswaran, P., Srivastava, Binod Kumar, Biswas, Moumita, Mallick, Gayadhar, Bera, Om Prakash, Sahai, K. N., Murali, Lakshmi, Kamble, Sanjeev, Deshpande, Madhav, Kumar, Naresh, Kumar, Sunil, Jaisingh, A. James Jeyakumar, Naqvi, Ali Jafar, Verma, Prafulla, Ansari, Mohammed Salauddin, Mishra, Prafulla C., Sumesh, G, Barik, Sanjeeb, Mathew, Vijesh, Lohar, Manas Ranjan Singh, Gaurkhede, Chandrashekhar S., Parate, Ganesh, Bale, Sharifa Yasin, Koli, Ishwar, Bharadwaj, Ashwin Kumar, Venkatraman, G., Sathiyanarayanan, K., Lal, Jinesh, Sharma, Ashwini Kumar, Rao, Raghuram, Kumar, Ajay M. V., Chadha, Sarabjit Singh
    Publicado 2019
    “…BACKGROUND: Axshya SAMVAD is an active tuberculosis (TB) case finding (ACF) strategy under project Axshya (Axshya meaning ‘free of TB’ and SAMVAD meaning ‘conversation’) among marginalized and vulnerable populations in 285 districts of India. …”
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    Patient characteristics, health seeking and delays among new sputum smear positive TB patients identified through active case finding when compared to passive case finding in India
  9. 484009
    “…The ExteNET study showed that neratinib significantly improved 5-year invasive disease-free survival (iDFS) in women who completed trastuzumab-based adjuvant therapy for early breast cancer (EBC). …”
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    PIK3CA alterations and benefit with neratinib: analysis from the randomized, double-blind, placebo-controlled, phase III ExteNET trial
  10. 484010
    “…Baseline serum levels of IL-1α were measured using ELISA from HNSCC patients treated with cetuximab-based therapy and analyzed for association with progression free survival (PFS). RESULTS: Cetuximab induced pro-inflammatory cytokine secretion from HNSCC cells in vitro which was mediated by an IL-1α/IL-1R1/MyD88-dependent signaling pathway. …”
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    Interleukin-1 alpha increases anti-tumor efficacy of cetuximab in head and neck squamous cell carcinoma
  11. 484011
    “…Smartphones and data plans were provided free of charge by study investigators. DOT or VOT observation records were completed by observers until treatment or study end. …”
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    Smartphone-enabled video-observed versus directly observed treatment for tuberculosis: a multicentre, analyst-blinded, randomised, controlled superiority trial
  12. 484012
    “…Overall Survival (OS) and Progression Free Survival (PFS) were the main outcomes. Analysis was performed using Random Survival Forests (RSF)/ multivariable Cox Proportional-Hazards models. …”
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    Complex inter-relationship of body mass index, gender and serum creatinine on survival: exploring the obesity paradox in melanoma patients treated with checkpoint inhibition
  13. 484013
    por Ziedan, Ahmed, Bhandari, Sunil
    Publicado 2019
    “…We hypothesize that IV iron leads to changes in oxidative stress, endothelial function, and potential renal damage depending on the iron formulation (related to the generation of “free” or catalytic labile iron) and this may result in more tubular and glomerular injury manifested as increased proteinuria and raised neutrophil gelatinase–associated lipocalin (NGAL) levels in patients with chronic kidney disease (CKD). …”
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    Protocol and baseline data for a prospective open-label explorative randomized single-center comparative study to determine the effects of various intravenous iron preparations on markers of oxidative stress and kidney injury in chronic kidney disease (IRON-CKD)
  14. 484014
    “…Further studies are required to independently confirm that Ca isotope measurement provide a sensitive, non-invasive and radiation-free method for the diagnosis of osteoporosis.…”
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    Calcium isotope ratios in blood and urine: A new biomarker for the diagnosis of osteoporosis
  15. 484015
    “…Four programs (4/14, 29%) were publicly available and free of charge, whereas others were restricted to research settings (5/14, 36%), available after payment (1/14, 7%), or not available at all (2/14, 14%). …”
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    Web-Based Multidomain Lifestyle Programs for Brain Health: Comprehensive Overview and Meta-Analysis
  16. 484016
    “…Balanced steady-state free precession sequences (bSSFP) were used for assessment of left ventricular (LV) volumes and ejection fraction. …”
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    Myocardial fibrosis by late gadolinium enhancement cardiovascular magnetic resonance in myotonic muscular dystrophy type 1: highly prevalent but not associated with surface conduction abnormality
  17. 484017
    “…METHODS: In a randomised crossover study, 19 patients with type 2 diabetes (13 men/6 women, 63 ± 9 years old) who were not using insulin each followed three regimens under free-living conditions, each lasting 4 days: (1) Sitting: 4415 steps/day with 14 h sitting/day; (2) Exercise: 4823 steps/day with 1.1 h/day of sitting replaced by moderate- to vigorous-intensity cycling (at an intensity of 5.9 metabolic equivalents [METs]); and (3) Sit Less: 17,502 steps/day with 4.7 h/day of sitting replaced by standing and light-intensity walking (an additional 2.5 h and 2.2 h, respectively, compared with the hours spent doing these activities in the Sitting regimen). …”
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    Breaking sitting with light activities vs structured exercise: a randomised crossover study demonstrating benefits for glycaemic control and insulin sensitivity in type 2 diabetes
  18. 484018
    “…Kaplan-Meier analysis (KMA) calculated overall survival (OS) and recurrence free survival (RFS). Multivariable analysis (MVA) was performed to identify factors associated with increased SUA levels and all-cause mortality. …”
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    Rising Serum Uric Acid Level Is Negatively Associated with Survival in Renal Cell Carcinoma
  19. 484019
    “…METHODS: NowMattersNow.org is an online video-based free public resource that provides evidence-based teachings, examples, and resources for managing suicidal thoughts and intense emotions focused largely around skills from dialectical behavior therapy. …”
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    Development and Evaluation of a Web-Based Resource for Suicidal Thoughts: NowMattersNow.org
  20. 484020
    “…When compared to surgery alone, adjuvant therapy with either CT or CRT had no statistically significant difference in terms of progression-free survival (p=0.56) or overall survival (p=0.80). …”
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    Clinical Outcome of Ampullary Carcinoma: Single Cancer Center Experience
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