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484021“…The second outcomes included ankle-brachial index (ABI), transcutaneous oxygen tension (TcO2), pain-free walking distance (PFWD), and rest pain score. …”
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484022por Barker, Anna, Cameron, Peter, Flicker, Leon, Arendts, Glenn, Brand, Caroline, Etherton-Beer, Christopher, Forbes, Andrew, Haines, Terry, Hill, Anne-Marie, Hunter, Peter, Lowthian, Judy, Nyman, Samuel R., Redfern, Julie, Smit, De Villiers, Waldron, Nicholas, Boyle, Eileen, MacDonald, Ellen, Ayton, Darshini, Morello, Renata, Hill, Keith“…Participants were enrolled if they could walk without hands-on assistance, use a telephone, and were free of cognitive impairment (Mini-Mental State Examination > 23). …”
Publicado 2019
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484023por Shi, Yuankai, Li, Jin, Xu, Jianming, Sun, Yan, Wang, Liwei, Cheng, Ying, Liu, Wei, Sun, Guoping, Chen, Yigui, Bai, Li, Zhang, Yiping, He, Xiaohui, Luo, Yi, Wang, Zhehai, Liu, Yunpeng, Yao, Qiang, Li, Yuhong, Qin, Shukui, Hu, Xiaohua, Bi, Feng, Zheng, Rongsheng, Ouyang, Xuenong“…The primary endpoints were overall response rate (ORR) and median progression-free survival (PFS). The secondary endpoints were median overall survival (OS), disease control rate (DCR), clinical benefit rate (CBR), and duration of response (DOR). …”
Publicado 2019
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484024por Bruera, Gemma, Massacese, Silvia, Pepe, Francesco, Malapelle, Umberto, Dal Mas, Antonella, Ciacco, Eugenio, Calvisi, Giuseppe, Troncone, Giancarlo, Simmaco, Maurizio, Ricevuto, Enrico“…At a median follow up of 18 months, progression-free survival (PFS) was 12, and overall survival (OS) was 23 months. …”
Publicado 2019
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484025por Liu, Jixian, Mu, Zhimin, Liu, Li, Li, Kang, Jiang, Richeng, Chen, Peng, Zhou, Qiang, Jin, Meiling, Ma, Yuxiang, Xie, Yuancai, Xiang, Jianxing, Li, Bing, Ma, Yafeng, Mao, Xinru, Zhang, Lu, Zhang, Tengfei, Wu, Da“…Before the detection of EGFR-ALK co-alterations, some patients were treated with EGFR-TKIs (n=16) according to previously detected EGFR alterations; Kaplan–Meier analysis revealed that EML4-ALK/EGFR co-altered patients (n=7) had a significantly shorter progression-free survival (PFS) after EGFR-TKI treatment than that of non-EML4-ALK/EGFR co-altered patients (n=8; mPFS, 6.0 vs 15.0 months, p=0.046). …”
Publicado 2019
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484026por Fennoy, Ilene, Sehgal, Neha, Stolze, Kristyn, Tao, Rachel, Zitsman, Jeffrey, Vuguin, Patricia, Oberfield, Sharon“…Another, 14 were hyperandrogenic (total testosterone>50ng/dl and/or free testosterone >5.3 pg/ml) with regular menses. …”
Publicado 2019
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484027por Meyreles Chaljub, Gustavo, Torres Potter, Losty, Troya, Pedro, Candelario-Cosme, Madeline, Weare-Regales, Natalia“…Further testing showed low AM cortisol <1.0 ug/dL (n 6.7-22.6 ug/dL), high ACTH (1010, n 6-50pg), TSH 7 (n 0.35 - 4.94 UIU/ML), Free T4 0.70 (n 0.70 - 1.48 NG/DL), TPO antibodies 759.06 (n<5.61 IU/ML), low aldosterone level <1.0 (n 3 - 16 ng/dL), and high renin activity 19.53 (n 0.25 - 5.82 ng/mL/h). …”
Publicado 2019
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484028por Chen, Kristina, Gosmanova, Elvira, Curhan, Gary, Rejnmark, Lars, Mu, Fan, Swallow, Elyse, Sherry, Nicole, Macheca, Monica, Ketteler, Markus“…CKD stages were identified by diagnosis codes, estimated glomerular filtration rate (eGFR) lab values (calculated using the CKD-EPI formula), and dialysis procedure codes. Among those free of CKD at baseline, the risk of incident CKD stage ≥ 3 was compared between cohorts using Kaplan-Meier analysis and adjusted Cox proportional hazards models. …”
Publicado 2019
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484029por Singarayar, Carolina, Rajakumar, Radhamani, Kamaruddin, Nor, Sukor, Norlela, Rahmatullah, Ijaz, Rahim, Anilah, Wahab, Norasyikin“…Serum chromogranin A was elevated (530.2ng/mL, n:27-94). 24h urinary free metanephrine was normal. Selective ACTH sampling was done together with bilateral inferior petrosal sinus sampling to elicit source of ACTH. …”
Publicado 2019
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484030por Yuen, Kevin, Giordano, Carla, Deutschbein, Timo, Manetti, Luca, Roughton, Michael, Kriemler-Krahn, Ulrike, Tauchmanova, Libuse, Maamari, Ricardo, Schopohl, Jochen“…Background: Clinical trials have shown that subcutaneous (sc) pasireotide effectively decreases urinary free cortisol (UFC), improves signs/symptoms and has a favorable safety profile in patients with Cushing’s disease (CD). …”
Publicado 2019
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484031por Chen, Kristina, Curhan, Gary, Gosmanova, Elvira, Rejnmark, Lars, Ketteler, Markus, Mu, Fan, Swallow, Elyse, Signorovitch, James, Sherry, Nicole, Kaul, Sanjiv“…Patient characteristics at baseline (the 6 months prior to index date) were compared between cohorts. Among those free of each CV condition at baseline, the risks of first occurrence of each condition during the study period were compared using Kaplan-Meier analysis and adjusted Cox proportional hazards models. …”
Publicado 2019
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484032“…We recorded morning serum free T4 (fT4) and TSH, and morning LH, FSH, estradiol (E, premenopausal only) or testosterone (T, in men only) values before (0M), and 6M and 12M after definitive surgery. …”
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484033por Diana, Tanja, Ungerer, Martin, Reimann, Andreas, Faßbender, Julia, Kanitz, Michael, Kahaly, George“…In contrast, baseline TBII were highly positive in all Ad-TSHR-immunized mice (median 40 IU/L, 25%-75% percentiles 40-40 IU/L, normal cut-off 0.55 IU/L) All these mice also developed hyperthyroidism with elevated free T4 (fT4) levels (median 4.5 ng/dl, 25-75 percentile 4.1-6 ng/dl; normal range 0.9-1.8 ng/dl). …”
Publicado 2019
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484034“…Lab work revealed low morning serum cortisol <1.2 mcg/dl (10-20 mcg/dl),high TSH 37.1 mU/L (0.4-4.5Mu/L), low free T4 0.2 mcg/dl (4.5-11.2 mcg/dl), low insulin 1.6 mcU/ml (4-30 mcU/dl), low C peptide 0.48 ng/ml (1.1-22 ng/ml), elevated prolactin 31 ng/ml (2-29 ng/dl), and low FSH 10 mlU/ml (26-134 mlU/ml). …”
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484035“…K15-SKO mice have increased body weight and fat mass, elevated circulating free-fatty acids and triglyceride, insulin insensitivity, and glucose intolerance compared to controls. …”
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484036por Anderson, Lindsey, Yin, Chelsea, Burciaga, Raul, Lee, Jonathan, Crabtree, Stephanie, Geiss, Kelsey, Migula, Dorota, Graf, Solomon, Chauncey, Tom, Garcia, Jose“…Plasma samples were analyzed for total testosterone (TT), dihydrotestosterone (DHT), dehydroepiandrosterone (DHEA), sex-hormone binding globulin (SHBG), 17-OHprogesterone, 17-OHpregnenelone, androstenedione, androsterone, pregnenolone, progesterone, estrone (E1), & estradiol (E2) via LCMS; bioavailable (BT) & free T (FT) were calculated using local laboratory-derived albumin levels. …”
Publicado 2019
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484037“…Background Endocrine Society recommends ≥2 low bioavailable (BAT) or free Testosterone (T) levels in the early AM by tandem mass spectroscopy to establish AD with DR. …”
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484038“…Cortisol post 1mg dexamethasone was 91 [5.0-25mcg/dL], post 8mg was 88 [5.0-25mcg/dL] and 24-hour free urine cortisol 5863 [3.5-45mcg/24hr]. Pituitary MRI showed a 0.4cm microadenoma and she underwent inferior petrosal sinus sampling that suggested ectopic production of ACTH. …”
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484039“…Labs then included TSH-37 mU/L (NL: 0.358-3.74) and Free T4 (FT4)-0.52 ng/dL (NL: 0.76-1.46) with elevated Anti-Peroxidase and Anti-Thyroglobulin antibody levels. …”
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484040por Stern, Naftali, Buch, Asaf, Tal, Brurya, Ben Haim, Limor, Sofer, Yael, Sack, Jessica, Shefer, Gabi, Osher, Esther“…Methods: Two 77y/o outpatient men were instructed to avoid any caloric intake, but consume calorie-free fluids ad libitum for 36 hours (last evening meal on the pre-fasting day; first next meal◊ breakfast on the post- fasting day), twice a week (total fasting hours 72/168 weekly hours) over 17 [patient A; A] and 13 months [patient B; B]. …”
Publicado 2019
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