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484461por Elhassan, Yasir, Altieri, Barbara, Berhane, Sarah, Cosentini, Deborah, Calabrese, Anna, Haissaguerre, Magalie, Kastelan, Darko, Fragoso, Maria C, Bertherat, Jerome, Baudin, Eric, Haak, Harm, Boudina, Maria, Canu, Letizia, Loli, Paola, Sherlock, Mark, Kimpel, Otilia, Marta, Laganà, Kroiss, Matthias, Arlt, Wiebke, Terzolo, Massimo, Berruti, Alfredo, Deeks, Jonathan, Libe, Rossella, Fassnacht, Martin, Ronchi, Cristina Lucia“…The mGRAS score was calculated as follows: age (<50yr=0; ≥50yr =1), symptoms (no=0; yes=1), ENSAT stage (1–2=0; 3=1; 4=2), resection status (R0=0; RX=1; R1=2; R2=3), and Ki67 (0–9%=0; 10–19%=1; ≥20%=2 points), generating scores from 0 to 9 and four mGRAS groups (scores 0–1, 2–3, 4–5, and 6–9). Progression-free survival (PFS) and disease-specific survival (DSS) were the primary and secondary endpoints, respectively. …”
Publicado 2021
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484462por Ortega, Madison Taylor, McGrath, John, Carlson, Lauren, Poccia, Vanessa Flores, Larson, Gary, Douglas, Christian, Sun, Bob Zhe, Zhao, Shanshan, Vesper, Hubert W, Duke, Lumi, Botelho, Julianne Cook, Filie, Armando C, Shaw, Natalie“…There was an interaction between time and TBF for FSH, INHB, E1, Total T, Free T, and A’dione (p<0.05): levels were initially similar in all TBF groups, but after 1 yr, levels increased in girls with higher TBF, plateaued in girls with mid-range TBF, and decreased in girls with lower TBF. …”
Publicado 2021
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484463“…Postoperatively, she had resolution of HTN and normalization of 24 hour urine free cortisol. UA is increasingly becoming recognized as a successful treatment for BMAH due to lower risk of adrenal crisis when compared to B/L adrenalectomy. …”
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484464por Li, Fenge, Deng, Ligang, Jackson, Kyle R, Talukder, Amjad H, Katailiha, Arjun S, Bradley, Sherille D, Zou, Qingwei, Chen, Caixia, Huo, Chong, Chiu, Yulun, Stair, Matthew, Feng, Weihong, Bagaev, Aleksander, Kotlov, Nikita, Svekolkin, Viktor, Ataullakhanov, Ravshan, Miheecheva, Natalia, Frenkel, Felix, Wang, Yaling, Zhang, Minying, Hawke, David, Han, Ling, Zhou, Shuo, Zhang, Yan, Wang, Zhenglu, Decker, William K, Sonnemann, Heather M, Roszik, Jason, Forget, Marie-Andree, Davies, Michael A, Bernatchez, Chantale, Yee, Cassian, Bassett, Roland, Hwu, Patrick, Du, Xueming, Lizee, Gregory“…Aside from transient rash, fatigue and/or fever observed in three patients, no other treatment-related adverse events were observed. Median progression-free survival and overall survival of the 24 vaccinated patients were 6.0 and 8.9 months, respectively. …”
Publicado 2021
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484465por Choudhary, Manojkumar, Solomon, Roma, Awale, Jitendra, Dey, Rina, Singh, Jagajeet Prasad, Weiss, William“…This was the CORE Group Polio Project (CGPP) India, a partner of the Uttar Pradesh (UP) SM Network and which continued its SM activities, even during the polio-free period through a network of multi-level social mobilizers. …”
Publicado 2021
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484466por Wang, Xiaoming, Guo, Shiwei, Li, Zhiqian, Luo, Qiang, Dai, Yan, Zhang, Hu, Ye, Yun, Gong, Qiyong, Luo, Kui“…CONCLUSIONS: As a safe and efficient candidate metal-free magnetic resonance contrast agent, Branched pDHPMA-mPEG-Ppa-PROXYL is expected to be used not only in imaging the tumor, liver and kidney, but also the cardiovascular system, which expands the application scope of these CAs. …”
Publicado 2021
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484467por Liu, Zining, Wang, Yinkui, Shan, Fei, Ying, Xiangji, Zhang, Yan, Li, Shuangxi, Jia, Yongning, Miao, Rulin, Xue, Kan, Li, Zhemin, Li, Ziyu, Ji, Jiafu“…This study aimed to assess and establish a novel scoring system incorporating carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), carbohydrate antigen 72-4 (CA72-4) to enhance prognostic accuracy for progression-free survival (PFS) and pathological response (pCR). …”
Publicado 2021
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484468MicroRNA-based signatures impacting clinical course and biology of ovarian cancer: a miRNOmics studypor Krasniqi, E., Sacconi, A., Marinelli, D., Pizzuti, L., Mazzotta, M., Sergi, D., Capomolla, E., Donzelli, S., Carosi, M., Bagnato, A., Gamucci, T., Tomao, S., Natoli, C., Marchetti, P., Grassadonia, A., Tinari, N., De Tursi, M., Vizza, E., Ciliberto, G., Landi, L., Cappuzzo, F., Barba, M., Blandino, G., Vici, P.“…RESULTS: In the IRE cohort, downregulation of the 2 miRNA-signature including miR-99a-5p and miR-320a held a negative prognostic relevance, while upregulation of miR-224-5p was predictive of less favorable event free survival (EFS) and P-res. Data from the TCGA showed that downregulation of 5 miRNAs, i.e., miR-150, miR-30d, miR-342, miR-424, and miR-502, was associated with more favorable EFS and overall survival outcomes, while miR-200a upregulation was predictive of P-res. …”
Publicado 2021
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484469por Daniello, Lea, Elshiaty, Mariam, Bozorgmehr, Farastuk, Kuon, Jonas, Kazdal, Daniel, Schindler, Hannah, Shah, Rajiv, Volckmar, Anna-Lena, Lusky, Fabienne, Diekmann, Leonore, Liersch, Stephan, Faehling, Martin, Muley, Thomas, Kriegsmann, Mark, Benesova, Karolina, Stenzinger, Albrecht, Thomas, Michael, Christopoulos, Petros“…Patients developing irAE had longer progression-free (PFS) and overall survival (OS) in multivariable 12/14-week landmark analyses including ECOG status, treatment line, treatment type, PD-L1 TPS, and NLR (median PFS 17 vs. 10 months, HR = 0.68, p = 0.009; median OS 37 vs. 15 months, HR = 0.40, p < 0.001), regardless of grade. …”
Publicado 2021
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484470por Bucar, Sara, Branco, André Dargen de Matos, Mata, Márcia F., Milhano, João Coutinho, Caramalho, Íris, Cabral, Joaquim M. S., Fernandes-Platzgummer, Ana, da Silva, Cláudia L.“…UCB cells were cultured in serum-free medium supplemented with SCF/TPO/FLT3-L/bFGF. …”
Publicado 2021
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484471por Gu, Zhen-Yang, Dong, Yu-Jun, Fu, Xiao-Rui, Li, Nai-Nong, Liu, Yao, Wu, Xiao-Xiong, Wang, Yi-Ni, Li, Yu-Hang, Ren, Han-Yun, Zhang, Ming-Zhi, Li, Xiao-Fan, Wang, Mai-Hong, Wu, Ya-Mei, Liu, Dai-Hong, Wang, Zhao, Hu, Liang-Ding, Huang, Wen-Rong“…With a median follow-up of 30 (2–143) months, 3-year overall survival (OS) and progression-free survival (PFS) in the auto-HSCT group were 70%(48/63) and 59%(42/63), respectively. …”
Publicado 2021
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484472por Keim-Malpass, Jessica, Ratcliffe, Sarah J, Moorman, Liza P, Clark, Matthew T, Krahn, Katy N, Monfredi, Oliver J, Hamil, Susan, Yousefvand, Gholamreza, Moorman, J Randall, Bourque, Jamieson M“…RESULTS: The primary outcome will be hours free from events of clinical deterioration. Hours of acute clinical events are defined as time when one or more of the following occur: emergent ICU transfer, emergent surgery prior to ICU transfer, cardiac arrest prior to ICU transfer, emergent intubation, or death. …”
Publicado 2021
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484473por Kang, Byung Soo, Lee, San Ha, Kim, Woo Jeng, Wie, Jeong Ha, Park, In Yang, Ko, Hyun Sun“…Independent factors effecting routine recommendation were “working at a private clinic or hospital” (OR 5.33, 95% CI 2.44–11.65), “awareness of KCDC guidelines” (OR 3.11, 95% CI 1.11–8.73), and “awareness of the 2019 national free influenza vaccination program for pregnant women” (OR 4.88, 95% CI 2.34–10.17). …”
Publicado 2021
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484474por Rayner, Fiona, Anderson, Amy E., Baker, Kenneth F., Buckley, Christopher D., Dyke, Bernard, Fenton, Sally, Filer, Andrew, Goodyear, Carl S., Hilkens, Catharien M. U., Hiu, Shaun, Kerrigan, Sean, Kurowska-Stolarska, Mariola, Matthews, Fiona, McInnes, Iain, Ng, Wan-Fai, Pratt, Arthur G., Prichard, Jonathan, Raza, Karim, Siebert, Stefan, Stocken, Deborah, Teare, M. Dawn, Young, Stephen, Isaacs, John D.“…It is anticipated that 50% of participants will have a disease flare, whilst 50% remain in drug-free remission for the study duration (24 weeks). …”
Publicado 2021
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484475por Sun, Haibo, Martin, Thomas G, Marra, John, Kong, Denice, Keats, Jonathon, Macé, Sandrine, Chiron, Marielle, Wolf, Jeffrey L, Venstrom, Jeffrey M, Rajalingam, Raja“…BACKGROUND: Phase IIb clinical trial with isatuximab (Isa)-lenalidomide (Len)-dexamethasone (Dex) showed an improved progression-free survival (PFS) in patients with relapsed or refractory multiple myeloma (RRMM), but the efficacy varied by patient. …”
Publicado 2021
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484476por Guidon, Amanda C, Burton, Leeann B, Chwalisz, Bart K, Hillis, James, Schaller, Teilo H, Amato, Anthony A, Betof Warner, Allison, Brastianos, Priscilla K, Cho, Tracey A, Clardy, Stacey L, Cohen, Justine V, Dietrich, Jorg, Dougan, Michael, Doughty, Christopher T, Dubey, Divyanshu, Gelfand, Jeffrey M, Guptill, Jeffrey T, Johnson, Douglas B, Juel, Vern C, Kadish, Robert, Kolb, Noah, LeBoeuf, Nicole R, Linnoila, Jenny, Mammen, Andrew L, Martinez-Lage, Maria, Mooradian, Meghan J, Naidoo, Jarushka, Neilan, Tomas G, Reardon, David A, Rubin, Krista M, Santomasso, Bianca D, Sullivan, Ryan J, Wang, Nancy, Woodman, Karin, Zubiri, Leyre, Louv, William C, Reynolds, Kerry L“…Panelists rated content for usability, appropriateness and accuracy on 9-point scales in electronic surveys and provided free text comments. Aggregated survey responses were incorporated into revised definitions. …”
Publicado 2021
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484477por Syrigos, Konstantinos, Abert, Istvan, Andric, Zoran, Bondarenko, Igor N, Dvorkin, Mikhail, Galic, Kristina, Galiulin, Rinat, Kuchava, Vladimer, Sriuranpong, Virote, Trukhin, Dmytro, Zhavrid, Edvard, Fu, Dongyue, Kassalow, Laurent M, Jones, Stephanie, Bashir, Zahid“…Other efficacy determinations included progression-free survival (PFS), overall survival (OS), and immunogenicity. …”
Publicado 2021
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484478Publicado 2021“…The immune phenotypes independent of the International Prognostic Index(IPI)that affect overall survival(OS)and progression-free survival(PFS)of DLBCL were explored by COX regression model, and the effect of their co-expression on the prognosis were also analyzed. …”
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484479por Jia, Ning, Chang, Lianpeng, Gao, Xin, Shi, Xiaohua, Dou, Xuelin, Guan, Mei, Shao, Yajuan, Li, Ningning, Cheng, Yuejuan, Ying, Hongyan, Sun, Zhao, Zhou, Yanping, Zhao, Lin, Zhou, Jianfeng, Bai, Chunmei“…Patients with newly detected mutations had shorter progression-free survival (PFS) compared to those without (median 3.0 versus 7.3 months; hazard ratio (HR), 5.97; 95% confidence interval (CI), 0.70–50.69; P = 0.0003). …”
Publicado 2021
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484480por Mirmiran, Parvin, Aghayan, Maryam, Bakhshi, Bahar, Hosseinpour-Niazi, Somayeh, Azizi, Fereidoun“…METHODS: This is a prospective study of 1915 participants (male, 40.5%), aged 19–74 year who were free of MetS at baseline. Dietary intakes were gathered using a validated, semi-quantitative food frequency questionnaire at baseline (2006–2008), and with 3-year intervals afterwards. …”
Publicado 2021
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