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  1. 484721
    “…BACKGROUND: Natural immunity against Mycobacterium tuberculosis exists, and > 90% of those infected remain disease-free. Innate and adaptive immune responses required to mediate such protection against tuberculosis (TB) are, however, poorly understood. …”
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    Cascade Immune Mechanisms of Protection against Mycobacterium tuberculosis (IMPAc-TB): study protocol for the Household Contact Study in the Western Cape, South Africa
  2. 484722
    “…The secondary objectives are: safety and tolerability, measurement of Sn-117 m-DTPA activity by gamma-camera dosimetry scans, therapeutic efficacy, time to the first symptomatic skeletal event, duration of pain response, changes in PSA and ALP levels, patient-reported outcomes and progression free survival and overall survival. DISCUSSION: Sn-117 m-DTPA is a unique bone-targeting theranostic radiopharmaceutical agent that selectively binds most heavily to bone metastases sites. …”
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    A single arm phase II study of bone-targeted Sn-117 m-DTPA in symptomatic castration-resistant prostate cancer with skeletal metastases
  3. 484723
    “…The primary outcome will be the change in distances walked (maximal and pain-free) from baseline to 3 and 6 months. Secondary outcomes will be changes in quality of life, patients’ perception of resistance, and walking speed. …”
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    WalkingPad protocol: a randomized clinical trial of behavioral and motivational intervention added to smartphone-enabled supervised home-based exercise in patients with peripheral arterial disease and intermittent claudication
  4. 484724
    “…The estimated 36-month progression-free survival (PFS) was 73% and the estimated 36-month overall survival (OS) was 85%, with no differences between HCL and HCL-V. …”
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    Updates in hairy cell leukemia (HCL) and variant-type HCL (HCL-V): rationale for targeted treatments with a focus on ibrutinib
  5. 484725
    “…The study was conducted between January 21 and February 8, 2021 based on a questionnaire including 25 single or multiple-choice questions, made using the free software Limesurvey. The link of the questionnaire was distributed to the students by the teachers and the student associations. …”
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    Cross-sectional study on COVID-19 vaccine hesitancy and determinants in healthcare students: interdisciplinary trainings on vaccination are needed
  6. 484726
    “…Following the demands of patients and clinicians for metal-free restorations, all-ceramic materials were developed as they offer an adequate alternative with better optical qualities and good mechanical properties. …”
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    Comparative Assessment of the Functional Parameters for Metal-Ceramic and All-Ceramic Teeth Restorations in Prosthetic Dentistry—A Literature Review
  7. 484727
    “…A biological response was achieved in 55.4% of patients at week 8, and 59.3% were in steroid-free remission at the end of follow-up. No significant differences in either clinical or biological remission were noted between bio-naïve and bio-experienced patients. …”
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    Long-term effectiveness and safety of ustekinumab in bio-naïve and bio-experienced anti-tumor necrosis factor patients with Crohn’s disease: a real-world multicenter Brazilian study
  8. 484728
    “…Satisfaction and impact on clinical practice were explored using questionnaires at 10 and 16-months, with free-form responses identifying enablers and barriers to EBP culture and implementation. …”
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    Long term tailored implementation of structured “TREAT” journal clubs in allied health: a hybrid effectiveness-implementation study
  9. 484729
    “…OBJECTIVE: The aims of this study are to describe the development of JitaBug, a personalized smartphone-delivered JITAI designed to support older adults to increase or maintain their PA level, assess the feasibility of conducting an effectiveness trial of the JitaBug intervention, and explore the acceptability of JitaBug among older adults in a free-living setting. METHODS: The intervention was developed using the Behavior Change Wheel and consisted of a wearable activity tracker (Fitbit) and a companion smartphone app (JitaBug) that delivered goal-setting, planning, reminders, and JITAI messages to encourage achievement of personalized PA goals. …”
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    A Personalized Smartphone-Delivered Just-in-time Adaptive Intervention (JitaBug) to Increase Physical Activity in Older Adults: Mixed Methods Feasibility Study
  10. 484730
    “…METHODS: Within the UK Biobank, 416,481 gout-free participants (aged 37–74) were identified at baseline. …”
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    Healthy lifestyle counteracts the risk effect of genetic factors on incident gout: a large population-based longitudinal study
  11. 484731
    “…RESULTS: High FGFR1 expression correlated with low relapse-free survival in two independent NB gene expression datasets. …”
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    FGFR1 is a potential therapeutic target in neuroblastoma
  12. 484732
    por Villar, Jesús, Mora-Ordoñez, Juan M., Soler, Juan A., Mosteiro, Fernando, Vidal, Anxela, Ambrós, Alfonso, Fernández, Lorena, Murcia, Isabel, Civantos, Belén, Romera, Miguel A., Mira, Adrián, Díaz-Domínguez, Francisco J., Parrilla, Dácil, Martínez-Carmona, J. Francisco, Martínez, Domingo, Pita-García, Lidia, Robaglia, Denis, Bueno-González, Ana, Sánchez-Ballesteros, Jesús, Pereyra, Ángel E., Hernández, Mónica, Chamorro-Jambrina, Carlos, Cobeta, Pilar, González-Luengo, Raúl I., Montiel, Raquel, Nogales, Leonor, Fernández, M. Mar, Arocas, Blanca, Valverde-Montoro, Álvaro, del Saz-Ortiz, Ana M., Olea-Jiménez, Victoria, Añón, José M., Rodríguez-Suárez, Pedro, Fernández, Rosa L., Fernández, Cristina, Szakmany, Tamas, González-Martín, Jesús M., Ferrando, Carlos, Kacmarek, Robert M., Slutsky, Arthur S.
    Publicado 2022
    “…Patients without ARDS had higher ventilator-free days than ARDS (12.2 ± 11.6 vs 9.3 ± 9.7 d; p < 0.001). …”
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    The PANDORA Study: Prevalence and Outcome of Acute Hypoxemic Respiratory Failure in the Pre-COVID-19 Era
  13. 484733
    “…METHODS: 218,237 men from UK Biobank who were free from cancer at baseline were included. Body mass index (BMI), total body fat percentage (using bioimpedance), waist circumference (WC) and waist-to-hip ratio (WHR) were collected at recruitment. …”
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    Adiposity and risk of prostate cancer death: a prospective analysis in UK Biobank and meta-analysis of published studies
  14. 484734
    “…BACKGROUND: In non-small cell lung cancer (NSCLC) patients receiving immune checkpoint inhibitors (ICIs), higher blood tumor mutational burden (bTMB) was usually associated with better progression-free survival (PFS) and objective response rate (ORR). …”
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    ctDNA-adjusted bTMB as a predictive biomarker for patients with NSCLC treated with PD-(L)1 inhibitors
  15. 484735
    “…All subjects received free gym memberships and physical activity guidance. …”
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    The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS)
  16. 484736
    “…Machine learning algorithm by Random Forest (RF) model was utilized to screen the robust prognostic markers and construct the CD68-based immune-related risk score (IRRS) for predicting disease-free survival (DFS). RESULTS: The expression levels of CD68 were moderately correlated with the levels of PD-L1 (P<0.001), CD133 (P<0.001), and CD8 (P<0.001). …”
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    Macrophages-based immune-related risk score model for relapse prediction in stage I–III non-small cell lung cancer assessed by multiplex immunofluorescence
  17. 484737
    “…Eight indicators of body water [total body water, extracellular water, intracellular water, free fat mass, active cell mass, extracellular water/intracellular water, extracellular water/total body water (ECW/TBW), and intracellular water/total body water] were included in the research. …”
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    Extracellular water to total body water ratio predicts survival in cancer patients with sarcopenia: a multi-center cohort study
  18. 484738
    “…Participants were recruited from the general population in the Greater Los Angeles area and were free of cardiovascular disease and diabetes; no cognitive or psychiatric exclusion criteria were specified. …”
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    Subclinical carotid artery atherosclerosis and cognitive function in older adults
  19. 484739
    “…The overall tumor control rate was 91.3%, and the actuarial 3-, 5-, and 10-year progression-free survival rates were 97.8%, 93.8%, and 76.9%, respectively. …”
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    Early-onset adverse events after stereotactic radiosurgery for jugular foramen schwannoma: a mid-term follow-up single-center review of 46 cases
  20. 484740
    “…Median overall and progression-free survival periods were 17.0 and 10.4 months, and the objective response rates according to Response Evaluation Criteria in Solid Tumor (RECIST) version 1.1 and modified RECIST criteria were 22.6% and 70.0%, respectively. …”
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    A prospective observational cohort study of lenvatinib as initial treatment in patients with BCLC-defined stage B hepatocellular carcinoma
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