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  1. 484781
    “…METHODS: Single fast-twitch fibres are separated from the intact muscle by a collagenase digest procedure. We use label-free second harmonic generation (SHG) imaging, ultra-fast video microscopy and skinned fibre measurements from our MyoRobot automated biomechatronics system to study the morphology, visco-elasticity, force production and mechanical strength of single fibres from the Actn3KO mouse. …”
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    Absence of the Z-disc protein α-actinin-3 impairs the mechanical stability of Actn3KO mouse fast-twitch muscle fibres without altering their contractile properties or twitch kinetics
  2. 484782
    “…The primary aim was to assess the 5-year recurrence-free survival (RFS) of low- and high-risk CP-GEP. …”
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    Using a Clinicopathologic and Gene Expression (CP-GEP) Model to Identify Stage I–II Melanoma Patients at Risk of Disease Relapse
  3. 484783
    “…Patients who were cancer free were frequency-matched with the breast cancer group by age (every five-year span) and index year. …”
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    Association between Breast Cancer and Second Primary Lung Cancer among the Female Population in Taiwan: A Nationwide Population-Based Cohort Study
  4. 484784
    “…CONCLUSIONS: This study provided initial support for the feasibility of the ENERGY System, a DMH tool capable of screening for resource and mental health needs and providing automated, personalized, and free resources and techniques to meet the identified needs. …”
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    Digital Screening and Automated Resource Identification System to Address COVID-19–Related Behavioral Health Disparities: Feasibility Study
  5. 484785
    “…All measurements are represented as mean and standard deviations. Moreover, free text comments from questionnaires were collected and aggregated. …”
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    Creation and application of war trauma treatment simulation software for first aid on the battlefield based on undeformed high-resolution sectional anatomical image (Chinese Visible Human dataset)
  6. 484786
    “…DESIGN: In a regional multicentre retrospective cohort study, electronic health record data were abstracted for a prepandemic group (pre-COVID) and two intrapandemic (March–August 2020, wave 1) groups, one COVID-19 free (COVID-ve) and one with COVID-19 infection (COVID+ve). …”
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    Comparative end-of-life communication and support in hospitalised decedents before and during the COVID-19 pandemic: a retrospective regional cohort study in Ottawa, Canada
  7. 484787
    “…We performed qualitative analyses of post-symposium free-text feedback using a grounded theory approach to identify participants’ intentions to change their practice. …”
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    The impact and feasibility of a brief, virtual, educational intervention for home healthcare professionals on Parkinson’s Disease and Related Disorders: pilot study of I SEE PD Home
  8. 484788
    “…The secondary endpoints include the pathological partial regression (pPR) rate, R0 resection rate, objective response rate (ORR), event-free survival (EFS), overall survival (OS), safety and surgical complications. …”
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    A study protocol of a randomized phase II trial of perioperative chemoimmunotherapy verses perioperative chemoimmunotherapy plus preoperative chemoradiation for locally advanced gastric (G) or gastroesophageal junction (GEJ) adenocarcinoma: the NeoRacing study
  9. 484789
    “…Quantitative data were analyzed using descriptive statistics, Fisher’s exact test, and logistic regression. Free-text answers were analyzed thematically using the “Master Suppression techniques” conceptual framework. …”
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    Discrimination in an “equal country”—a survey amongst Swedish final-year medical students
  10. 484790
    “…DNA extracted from the processed samples (and controls) were treated with propidium monoazide (PMA) to detect intact/viable cells or left untreated and to detect the total DNA population (free DNA/compromised cells/intact cells/viable cells). …”
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    Microbial Tracking-2, a metagenomics analysis of bacteria and fungi onboard the International Space Station
  11. 484791
    “…Horizontal analysis of free text responses by CFIR domain was done to contextualize the quantitative results. …”
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    How service delivery implementation strategies can contribute to attaining universal health coverage: lessons from polio eradication using an implementation science approach
  12. 484792
    “…The average number of hydrogen bonds formed per timeframe by CID:1, CID:2, CID:3, and CID:5 (0.914, 0.451, 1.566, and 1.755, respectively) were greater than that formed by ceftazidime (0.317). The total binding free energy calculations revealed that the five compounds interacted more strongly within RBD residues (CID:1 = − 68.8, CID:2 = − 71.6, CID:3 = − 74.9, CID:4 = − 75.4, CID:5 = − 60.9 kJ/mol) than ceftazidime (− 34.5 kJ/mol). …”
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    In silico screening of some compounds derived from the desert medicinal plant Rhazya stricta for the potential treatment of COVID-19
  13. 484793
    por Houser, Katherine V., Gaudinski, Martin R., Happe, Myra, Narpala, Sandeep, Verardi, Raffaello, Sarfo, Edward K., Corrigan, Angela R., Wu, Richard, Rothwell, Ro Shauna, Novik, Laura, Hendel, Cynthia S., Gordon, Ingelise J., Berkowitz, Nina M., Cartagena, Cora Trelles, Widge, Alicia T., Coates, Emily E., Strom, Larisa, Hickman, Somia, Conan-Cibotti, Michelle, Vazquez, Sandra, Trofymenko, Olga, Plummer, Sarah, Stein, Judy, Case, Christopher L., Nason, Martha, Biju, Andrea, Parchment, Danealle K., Changela, Anita, Cheng, Cheng, Duan, Hongying, Geng, Hui, Teng, I-Ting, Zhou, Tongqing, O'Connell, Sarah, Barry, Chris, Carlton, Kevin, Gall, Jason G., Flach, Britta, Doria-Rose, Nicole A., Graham, Barney S., Koup, Richard A., McDermott, Adrian B., Mascola, John R., Kwong, Peter D., Ledgerwood, Julie E.
    Publicado 2022
    “…Trimer 4571-specific binding antibodies were detected in all groups two weeks after regimen completion, primarily focused on the glycan-free trimer base. Neutralizing antibody activity was limited to the 500 mcg dose groups. …”
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    Safety and immunogenicity of an HIV-1 prefusion-stabilized envelope trimer (Trimer 4571) vaccine in healthy adults: A first-in-human open-label, randomized, dose-escalation, phase 1 clinical trial
  14. 484794
    “…The median progression-free survival was 5.7 months (95% CI 3.7–8.8 months). …”
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    Efficacy and safety of pomalidomide and low-dose dexamethasone in Chinese patients with relapsed or refractory multiple myeloma: a multicenter, prospective, single-arm, phase 2 trial
  15. 484795
    “…Likewise, in an in vitro cell-free system, the S59L mutation induces the aggregation of CHCHD10(S59L) protein while simultaneously enhancing the aggregation of recombinant TDP-43, as evidenced by filter trap assays and atomic force microscopy. …”
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    Modulation of synaptic plasticity, motor unit physiology, and TDP-43 pathology by CHCHD10
  16. 484796
    “…The higher ESBP score (>0·2) indicated a better prognosis for progression-free survival (hazard ratio: 0·36, 95% CI: 0·19–0·68, p<0·0001) in patients on the external test dataset. …”
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    A deep learning-based system for survival benefit prediction of tyrosine kinase inhibitors and immune checkpoint inhibitors in stage IV non-small cell lung cancer patients: A multicenter, prognostic study
  17. 484797
    “…This calculator is available online in the form of a free web-based tool that can aid clinicians in better patients counseling and treatment decision-making. …”
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    The Mount Sinai Prebiopsy Risk Calculator for Predicting any Prostate Cancer and Clinically Significant Prostate Cancer: Development of a Risk Predictive Tool and Validation with Advanced Neural Networking, Prostate Magnetic Resonance Imaging Outcome Database, and European Randomized Study of Screening for Prostate Cancer Risk Calculator
  18. 484798
    “…However, the logistic regression allowed us to identify significant RF when the women specifically reported personal life-dissatisfaction (aOR 9.6, 95% CI 1.90–17.68), emotional imbalances between happiness/sadness (aOR 7.1, 95% CI 1.49–13.57) and concentration/boredom (aOR 6.7, 95% CI 1.43–13.48); free-time dissatisfaction (aOR 5.5, 95% CI 1.17–5.70), public security unconformity (aOR 5.4, 95% CI 2.20–11.3), and sense of purposelessness (aOR 4.2, 95% CI 1.07–19.41). …”
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    Subjective well-being’s alterations as risk factors for major depressive disorder during the perimenopause onset: an analytical cross-sectional study amongst Mexican women residing in Guadalajara, Jalisco
  19. 484799
    “…Apart from three cases of de novo mNMIBC, the mean metastasis-free survival (MFS) interval of metachronous mNMIBC was 42.5 months, which was obviously longer than conventional metastatic bladder cancer. …”
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    Distant metastasis without regional progression in non-muscle invasive bladder cancer: case report and pooled analysis of literature
  20. 484800
    “…BACKGROUND: Excessive production of free radicals caused by many types of exercise results in oxidative stress, which leads to muscle damage, fatigue, and impaired performance. …”
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    Royal jelly plus coenzyme Q10 supplementation improves high-intensity interval exercise performance via changes in plasmatic and salivary biomarkers of oxidative stress and muscle damage in swimmers: a randomized, double-blind, placebo-controlled pilot trial
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