“…Additional labs: TSH 1.88 mIU/L, free thyroxine 0.46 ng/dL, IGF-1 62 ng/mL (109-284), prolactin 25 ng/mL, FSH 1.9 mIU/mL, LH 2.5 mIU/mL, total testosterone 183 ng/dL, and cortisol 3.2 ug/dL. …”
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“…Laboratory evaluation demonstrated TSH 0.97 uIU/mL (0.4–4. 0 uIU/mL), free T4 0.8 ng/dL (0.6-1.5 ng/dL), anti-TPO 16.9 IU/mL (<5. 0 IU/mL), and LDH 262 U/L (<240 U/L). …”
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“…Initial endocrinology work-up revealed noon time cortisol of 10.7 mcg/dL (range 7-23), 7 pm ACTH of 34.6 pg/mL (range 7.2-63.3), TSH of 1.71 mIU/mL (range 0.35- 4.94), free T4 of 0.93 ng/dL (range 0.5-1.39), FSH of 4.45 mIU/mL (range 1.27-19.26), LH 5.51 mIU/mL (range 1.24-8.62), IGF-1 level of 199 ng/mL (range 68-225), prolactin <0.60 ng/mL (range 2.64-13.13), and testosterone level of 186 ng/dL (range 175-800). …”
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“…Participants were asked to rank research topics within six domains based on the importance of the topic to their care: 1) care access/utilization within the program, 2) GAHT impacts on the body, 3) GAHT concerns/potential adverse effects, 4) gender-affirming surgeries, 5) mental health, and 6) navigating healthcare/work/school, with 6-7 choices in each category, including a free text option to fill out their own research priority. …”
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“…Endocrine workup revealed free T4 0.7 ng/dl, TSH 2.32 mIU/L, FSH 3.0 mIU/ml, LH 4.9 mIU/ml, estradiol 7 pg/ml, testosterone 59 ng/dl, random cortisol 8 ug/dl, ACTH 5.1 pg/ml, growth hormone <0.05 ng/ml, IGF-2 249 ng/ml and prolactin 10,470 ng/ml. …”
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“…The elevated 24-hour urinary free cortisol level (198 ug/dL; reference: 10-100 ug/24hr) and lack of suppression on the overnight 1-mg dexamethasone suppression test (morning cortisol 23.7 ug/dL) confirmed Cushing's syndrome; a high ACTH level of 92 pg/dL defined it as ACTH-dependent. …”
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“…A repeat DST was not performed given concerns for reduced dexamethasone clearance with her underlying renal and liver disease. Her 24-hour urine free cortisol (UFC) was elevated at 55 ug/24 hr (6-42 ug/24 hr). …”
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“…The patient denied any increase in her ring or shoe size, menstrual disturbances, loss of peripheral vision, orthostatic dizziness, or skin pigmentation.Her laboratory workup showed a serum prolactin of 33.3 ng/mL (reference value <25ng/mL), TSH of 2.11 mIU/L (reference value 0.5-5.0 mIU/L), free T4 of 1.3 ng/dL (reference value 0.7-1.9 ng/dL), IGF-1 of 250 ng/mL (reference value 90-360 ng/mL for people ages 40-54), morning ACTH of 6 pmol/L (reference value 10-60 pmol/L), and morning cortisol of <0.2 mcg/dL (reference value 5-25mcg/dL). …”
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“…Biochemical investigation of the patient revealed high triglyceride concentrations (3.81-6.49 mmol/L; NR 0.38-2) at all time points during an 18 hour fast. He mobilised free fatty acids but did not generate an increase in 3-hydroxybutyrate, suggesting a defect in fatty acid oxidation or ketone body synthesis. …”
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“…Three patients underwent testing due to discordance between the sex predicted by prenatal cell-free DNA testing and the external genital appearance on prenatal ultrasound or at birth (two were assigned female, one was assigned male). …”
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“…On testosterone replacement, biochemical assessment of anterior pituitary function showed total testosterone: 836 (264–916 ng/dl), Free Testosterone: 32.6 (2.5-9.5 ng/ml), LH<0.1 (1.2-8.6 IU/L), FSH 0.2 (1.5-12.4 IU/L), Prolactin 18 (4-26 ng/ml), TSH 0. 03(0.4-4.1 UIU/ml), FT4 0.63 (0.8-1.9ng/dl), IGF 188 (55-186 ng/ml), ACTH<5 (10-65 pg/ml), Cortisol<1 (4.8-19.5 ug/dl). …”
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“…There was no significant difference in the mean weight, BMI, WC, WHR, fat mass, fat percentage or fat free mass between the groups. Our study is the first ever RCT to show a significant improvement in total AMS (aging male symptom) scores from baseline after 6 months of TU treatment compared to placebo group (p<0.05) in a cohort with poorly-controlled type 2 diabetes and hypogonadism. …”
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“…Labs revealed total testosterone 398ng/dL (8-60ng/dL), free testosterone 9.15ng/dL (0. 06–0.87ng/dL), 17-hydroxyprogesterone 204ng/dL (<51ng/dL) CA-125 of 6.2U/mL (<=38.1U/mL) and DHEAS 23.1mcg/dL (18.9 – 205mcg/dL). …”
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“…Nevertheless, it supports improvement in recurrence-free and possibly overall-survival after complete radical resection in stage I, II or III ACC. …”
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“…Labs showed an ACTH of 32.9 pg/mL [9. 0-50. 0], cortisol 27.13 mcg/dL [3. 09-22.40], TSH 1.404 uIU/mL [0.550-4.780], with free T4 0.94 ng/dL [0.93-1.76] and total T4 of 11. 0 mcg/dL [4.5-10.9]. …”
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“…Due to the negative effects of BPA on human health, production of BPA-free products using analogs, such as BPS and BPF, has increased; yet their effects are still largely unknown. …”
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“…Consistent with PDL1-22C3, patients with higher PDL1-E1L3N expression (≥50%, 1–49%) have longer progression-free survival than those with PDL1-E1L3N TPS < 1%. …”
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“…RESULTS: The 8 non-pituitary CS patients enrolled comprised 5 with adrenal CS and 3 with ectopic CS. Baseline urinary free cortisol (UFC) was 2.57–75.2×ULN in patients with ectopic CS, and 0.42–27.76×ULN in the 4 adrenal patients with baseline UFC available. …”
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“…BACKGROUND: Free fatty acids (FFAs) are essential cell nutrients but also important signaling molecules regulating various cellular processes. …”
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“…RESULTS: Men with T < 264 ng/dL showed greater increases in total fat-free mass (FFM) at 18 months compared to those with T ≥ 264 ng/dL (4.2±4.1 vs 2.7±3.8%; p=0.047) and unadjusted appendicular FFM at 6 and 18 months (8.7±11.5 vs 4.4±4.3%, 7.3±11.6 vs 2.4±6.8%; p=0.033 and p=0.043, respectively). …”
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