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  1. 485621
    “…METHODS: In this study, male Nrg1 TM HET mice and wild type (WT) mice were treated with 30 mg/kg of CBD or vehicle intraperitoneally for three weeks during adolescence (PND 35–60). Mice were tested CBD-free in adulthood (5–6 mo) in the open field task, which measures locomotion and anxiety (related to positive symptoms in schizophrenia); social interaction, which measures mouse interactions (relevant to negative symptoms); pre-pulse inhibition (PPI), which measures sensorimotor gating (deficits also found in schizophrenia patients); and fear conditioning, which measures associative learning and memory. …”
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    T177. CANNABIDIOL AS A POTENTIAL PREVENTATIVE TREATMENT IN A NEUREGULIN-1 MOUSE MODEL OF SCHIZOPHRENIA
  2. 485622
    “…(Sub-)cortical reconstruction and volumetric segmentations were performed with FreeSurfer. Linear mixed model analyses were performed on brain measures, IQ, and EA within each cohort comparing FDRs to controls (taking family relatedness into account). …”
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    M166. THE EFFECT OF INTELLIGENCE AND EDUCATIONAL ATTAINMENT ON THE BRAIN IN THOSE WITH FAMILIAL HIGH RISK FOR SCHIZOPHRENIA OR BIPOLAR DISORDER: AN ENIGMA–RELATIVES STUDY
  3. 485623
    “…Images were pre-processed employing FreeSurfer 5.3.0, and data corresponding to Cortical Thickness (CTH) and Subcortical Volumes (SCV) was obtained. …”
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    S169. THE IMPACT OF PSYCHOSIS IN ADOLESCENT-ONSET BIPOLAR DISORDER: A STRUCTURAL MRI STUDY
  4. 485624
    “…All data paths were calculated with an asymptotically distribution-free model. The overall model fit was acceptable (RMSEA =.09) with a medium-strong effect of structural impairment on functional impairment (standardized estimate=.44). …”
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    S157. A MULTICENTER HARMONIZED DIFFUSION TENSOR IMAGING STUDY ON THE ASSOCIATION OF WHITE MATTER STRUCTURE AND CLINICAL FUNCTIONING
  5. 485625
    “…However, our results showed a significantly positive correlation in medication free cohort, and the significance become weaker in the medicated cohort. …”
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    T144. CORRELATION BETWEEN CEREBELLAR-PREFRONTAL NETWORK CONNECTIVITY AND NEGATIVE SYMPTOMS ASSOCIATED WITH THE STAGES OF SCHIZOPHRENIA
  6. 485626
    “…METHOD: We nominated 41 proteins (94 peptides) from the TMT CSF discovery dataset, representing a variety of brain cell-types and biological functions, for label-free PRM analysis in a replication cohort of 88 individuals that included 20 normal controls, 37 clinically diagnosed AD cases and 31 cases with non-AD cognitive impairment. …”
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    Targeted mass spectrometry to quantify brain-derived cerebrospinal fluid biomarkers in Alzheimer’s disease
  7. 485627
    “…METHODS: We performed a retrospective observational cohort study with data from the National Free Antiretroviral Treatment Program database. We included ART-naive patients aged 18 to 80 years who had contracted HIV through sex or injecting drugs, initiated first-line ART between January 2004 and December 2016, and had at least 60 days of follow-up. …”
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    Sex differences in HIV treatment outcomes and adherence by exposure groups among adults in Guangdong, China: A retrospective observational cohort study
  8. 485628
    “…The questionnaires used the following validated measurement scales: EQ-VAS; WHO-5 Well-Being Index; 3-item Loneliness Scale; Social Support Measure 3-item scale. Free text boxes also encouraged participants to discuss the merits of the programme. …”
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    A feasibility study of an exercise intervention to educate and promote health and well-being among medical students: the ‘MED-WELL’ programme
  9. 485629
    “…Total circulating lncRNA-GC1 was nearly all packaged within exosomes rather than a free form in plasma. CONCLUSIONS AND RELEVENCE: Circulating exosomal lncRNA-GC1 may serve as a noninvasive biomarker for detecting early-stage GC and for monitoring disease progression. …”
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    Circulating Exosomal Gastric Cancer–Associated Long Noncoding RNA1 as a Biomarker for Early Detection and Monitoring Progression of Gastric Cancer: A Multiphase Study
  10. 485630
    “…Others analyzed covariates included 12 prognostic factors that may be associated with chemotherapy resistance in previous studies: age, BMI, initial diagnosis time (The time from symptom onset to first medical attention), KPS score, initial tumor size, lymphocytes/leukocytes rate (LWR), neutrophils/lymphocytes rate (NLR), albumin, aspartate transaminase (AST), low density lipoprotein (LDL), blood urea nitrogen (BUN), alkaline phosphatase (ALP), the endpoints included progression-free survival (PFS) and overall survival (OS), response evaluation criteria in solid tumours by RECIST guideline (version 1.1). …”
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    Effects of different levels of TGF-β expression and tumor cell necrosis rates in osteosarcoma on the chemotherapy resistance of osteosarcoma
  11. 485631
    “…METHODS: This investigator-initiated, multicentric, randomised controlled open-label phase II clinical trial will test the hypothesis that the combination of SABR and L19-IL2 increases progression free survival (PFS) in patients with limited metastatic NSCLC. …”
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    Stereotactic ablative body radiotherapy (SABR) combined with immunotherapy (L19-IL2) versus standard of care in stage IV NSCLC patients, ImmunoSABR: a multicentre, randomised controlled open-label phase II trial
  12. 485632
    “…Associations between serum tumor biomarker improvements and objective response rate (ORR), progression-free survival (PFS), and overall survival (OS) were analyzed. …”
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    Dynamics of Serum Tumor Markers Can Serve as a Prognostic Biomarker for Chinese Advanced Non-small Cell Lung Cancer Patients Treated With Immune Checkpoint Inhibitors
  13. 485633
    por Atabaki-Pasdar, Naeimeh, Ohlsson, Mattias, Viñuela, Ana, Frau, Francesca, Pomares-Millan, Hugo, Haid, Mark, Jones, Angus G., Thomas, E. Louise, Koivula, Robert W., Kurbasic, Azra, Mutie, Pascal M., Fitipaldi, Hugo, Fernandez, Juan, Dawed, Adem Y., Giordano, Giuseppe N., Forgie, Ian M., McDonald, Timothy J., Rutters, Femke, Cederberg, Henna, Chabanova, Elizaveta, Dale, Matilda, Masi, Federico De, Thomas, Cecilia Engel, Allin, Kristine H., Hansen, Tue H., Heggie, Alison, Hong, Mun-Gwan, Elders, Petra J. M., Kennedy, Gwen, Kokkola, Tarja, Pedersen, Helle Krogh, Mahajan, Anubha, McEvoy, Donna, Pattou, Francois, Raverdy, Violeta, Häussler, Ragna S., Sharma, Sapna, Thomsen, Henrik S., Vangipurapu, Jagadish, Vestergaard, Henrik, ‘t Hart, Leen M., Adamski, Jerzy, Musholt, Petra B., Brage, Soren, Brunak, Søren, Dermitzakis, Emmanouil, Frost, Gary, Hansen, Torben, Laakso, Markku, Pedersen, Oluf, Ridderstråle, Martin, Ruetten, Hartmut, Hattersley, Andrew T., Walker, Mark, Beulens, Joline W. J., Mari, Andrea, Schwenk, Jochen M., Gupta, Ramneek, McCarthy, Mark I., Pearson, Ewan R., Bell, Jimmy D., Pavo, Imre, Franks, Paul W.
    Publicado 2020
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    Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts
  14. 485634
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    Increasing pediatric HIV testing positivity rates through focused testing in high-yield points of service in health facilities—Nigeria, 2016-2017
  15. 485635
    por Deftereos, Spyridon G., Giannopoulos, Georgios, Vrachatis, Dimitrios A., Siasos, Gerasimos D., Giotaki, Sotiria G., Gargalianos, Panagiotis, Metallidis, Simeon, Sianos, George, Baltagiannis, Stefanos, Panagopoulos, Periklis, Dolianitis, Konstantinos, Randou, Efthalia, Syrigos, Konstantinos, Kotanidou, Anastasia, Koulouris, Nikolaos G., Milionis, Haralampos, Sipsas, Nikolaos, Gogos, Charalampos, Tsoukalas, George, Olympios, Christoforos D., Tsagalou, Eleftheria, Migdalis, Ilias, Gerakari, Styliani, Angelidis, Christos, Alexopoulos, Dimitrios, Davlouros, Pericles, Hahalis, George, Kanonidis, Ioannis, Katritsis, Demosthenes, Kolettis, Theofilos, Manolis, Antonios S., Michalis, Lampros, Naka, Katerina K., Pyrgakis, Vlasios N., Toutouzas, Konstantinos P., Triposkiadis, Filippos, Tsioufis, Konstantinos, Vavouranakis, Emmanouil, Martinèz-Dolz, Luis, Reimers, Bernhard, Stefanini, Giulio G., Cleman, Michael, Goudevenos, John, Tsiodras, Sotirios, Tousoulis, Dimitrios, Iliodromitis, Efstathios, Mehran, Roxana, Dangas, George, Stefanadis, Christodoulos
    Publicado 2020
    “…The clinical primary end point rate was 14.0% in the control group (7 of 50 patients) and 1.8% in the colchicine group (1 of 55 patients) (odds ratio, 0.11; 95% CI, 0.01-0.96; P = .02). Mean (SD) event-free survival time was 18.6 (0.83) days the in the control group vs 20.7 (0.31) in the colchicine group (log rank P = .03). …”
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    Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized With Coronavirus Disease 2019: The GRECCO-19 Randomized Clinical Trial
  16. 485636
    “…Secondary endpoints include pain intensity as assessed with the numerical rating scale (NRS) for pain, time to return of intestinal function (defined as the time to first flatus and the time to the first postoperative intake of solid food), time to first mobilization, the incidence of postoperative nausea and vomiting during the first 24 h, length of stay on the post anesthesia care unit (PACU) and in the hospital, the extent of sensory block at two time points (admission to and discharge from the PACU), the doses of morphine IV as requested by the patient from the PCA pump, the total dosage of morphine administered IV, the need for and dose of rescue analgesics (ketamine, clonidine), free plasma ropivacaine levels after induction and at discharge from the PACU, and the incidence of adverse events during treatment (in particular, signs of local anesthetic systemic toxicity (LAST)). …”
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    Transmuscular quadratus lumborum (TQL) block for laparoscopic colorectal surgery: study protocol for a double-blind, prospective randomized placebo-controlled trial
  17. 485637
    “…Freedom from ADT/radiotherapy was 66.7% at 12-months. Pad-free rates were 100% pre-HIFU, 95.3% post-HIFU, 29.4% 3-months post-sRARP, and 65.5% 12-months post-sRARP. …”
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    Peri-operative, functional and early oncologic outcomes of salvage robotic-assisted radical prostatectomy after high-intensity focused ultrasound partial ablation
  18. 485638
    “…After combining PLR and NLR the Area under curve (AUC) of Hb based model raised from 0.76 to 0.78, with a category-free net reclassification improvement (NRI) of 0.532 (p < 0.001) and integrated discrimination improvement (IDI) of 0.029 (p < 0.001). …”
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    Association between neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and diabetic retinopathy among diabetic patients without a related family history
  19. 485639
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    High prevalence of non-communicable diseases among key populations enrolled at a large HIV prevention & treatment program in Kenya
  20. 485640
    por Wang, Mingyi, Kong, Weimeng, Marten, Ruby, He, Xu-Cheng, Chen, Dexian, Pfeifer, Joschka, Heitto, Arto, Kontkanen, Jenni, Dada, Lubna, Kürten, Andreas, Yli-Juuti, Taina, Manninen, Hanna E., Amanatidis, Stavros, Amorim, António, Baalbaki, Rima, Baccarini, Andrea, Bell, David M., Bertozzi, Barbara, Bräkling, Steffen, Brilke, Sophia, Murillo, Lucía Caudillo, Chiu, Randall, Chu, Biwu, De Menezes, Louis-Philippe, Duplissy, Jonathan, Finkenzeller, Henning, Carracedo, Loic Gonzalez, Granzin, Manuel, Guida, Roberto, Hansel, Armin, Hofbauer, Victoria, Krechmer, Jordan, Lehtipalo, Katrianne, Lamkaddam, Houssni, Lampimäki, Markus, Lee, Chuan Ping, Makhmutov, Vladimir, Marie, Guillaume, Mathot, Serge, Mauldin, Roy L., Mentler, Bernhard, Müller, Tatjana, Onnela, Antti, Partoll, Eva, Petäjä, Tuukka, Philippov, Maxim, Pospisilova, Veronika, Ranjithkumar, Ananth, Rissanen, Matti, Rörup, Birte, Scholz, Wiebke, Shen, Jiali, Simon, Mario, Sipilä, Mikko, Steiner, Gerhard, Stolzenburg, Dominik, Tham, Yee Jun, Tomé, António, Wagner, Andrea C., Wang, Dongyu S., Wang, Yonghong, Weber, Stefan K., Winkler, Paul M., Wlasits, Peter J., Wu, Yusheng, Xiao, Mao, Ye, Qing, Zauner-Wieczorek, Marcel, Zhou, Xueqin, Volkamer, Rainer, Riipinen, Ilona, Dommen, Josef, Curtius, Joachim, Baltensperger, Urs, Kulmala, Markku, Worsnop, Douglas R., Kirkby, Jasper, Seinfeld, John H., El-Haddad, Imad, Flagan, Richard C., Donahue, Neil M.
    Publicado 2020
    “…We also expect nitric acid and ammonia nucleation and rapid growth to be important in the relatively clean and cold upper free troposphere, where ammonia can be convected from the continental boundary layer and nitric acid is abundant from electrical storms(4,5).…”
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    Rapid growth of new atmospheric particles by nitric acid and ammonia condensation
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