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  1. 485641
    “…MAIN OUTCOMES AND MEASURES: Overall survival, whole-brain radiotherapy-free survival, and time to subsequent brain treatment. …”
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    Association of Innovations in Radiotherapy and Systemic Treatments With Clinical Outcomes in Patients With Melanoma Brain Metastasis From 2007 to 2016
  2. 485642
    Publicado 2018
    “…Except patients receiving HSCT, the median leukemia-free survival (LFS) time for patients in D-CAG group and CAG group was 18.0 (95%CI 6.6–29.4) months and 11.0 (95%CI 0–23.9) months respectively. …”
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    地西他滨联合半量CAG方案治疗骨髓增生异常综合征伴原始细胞增多和急性髓系白血病伴骨髓增生异常相关改变
  3. 485643
    Publicado 2016
    “…With the follow up to 20 June 2015, the overall survival (OS), progression free survival (PFS) and prognostic factor were analyzed. …”
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    诱导治疗序贯自体外周血造血干细胞移植后201例多发性骨髓瘤患者的疗效及预后影响因素
  4. 485644
    Publicado 2017
    “…METHODS: The response, NPM1 mutated transcript level after induction chemotherapy and the first 2 cycles of consolidation chemotherapy, disease-free survival (DFS) and overall survival (OS) in 137 patients with AML with NPM1 mutations of A, B and D were retrospectively analyzed. …”
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    早期评估NPM1突变阳性急性髓系白血病患者残留白血病水平的预后意义
  5. 485645
    “…Regarding the progression free survival (PFS), using a UVA of the tumor burden (p = 0.0004), bone (p = 0.0098) and brain (p = 0.0038) metastases, the presence of other metastatic sites (p = 0.0063), the number of metastatic sites (p = 0.0007), the histology (p = 0.0007), the use of immunotherapy as first line (p = 0.0031), and the ECOG PS ≥ 1 (p ≤ 0.0001) were associated with a lower PFS rate. …”
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    The Agnostic Role of Site of Metastasis in Predicting Outcomes in Cancer Patients Treated with Immunotherapy
  6. 485646
    “…METHODS: Based on the presence of matrix metalloproteinases that are overexpressed at the fracture site, we designed the matrix metalloproteinase–sensitive nanocapsules which were formed by in situ free radical polymerisation on the surface of MiR-21 with 2-(methacryloyloxy) ethyl phosphorylcholine and the bisacryloylated VPLGVRTK peptide. …”
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    MiR-21 nanocapsules promote early bone repair of osteoporotic fractures by stimulating the osteogenic differentiation of bone marrow mesenchymal stem cells
  7. 485647
    “…Primary endpoints: overall survival (OS), progression-free survival (PFS), and objective response rate (ORR) per independent radiology review committee in IMDC intermediate-risk/poor-risk patients. …”
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    Survival outcomes and independent response assessment with nivolumab plus ipilimumab versus sunitinib in patients with advanced renal cell carcinoma: 42-month follow-up of a randomized phase 3 clinical trial
  8. 485648
    Publicado 2017
    “…There were no significant differences of erythrocyte and platelet transfusions (P=0.074, P=0.059) within 1 month after transplantation. ②There were no significant differences with regard to the incidences of acute GVHD[23.1% (15/65) vs 34.8% (32/92), P=0.115], chronic GVHD[20.0% (13/65) vs 32.6% (32/92), P=0.081], Ⅱ–Ⅳ degree of acute GVHD[30.0% (13/65) vs 30.4% (30/92), P=0.287] and extensive chronic GVHD[9.2% (6/65) vs 20.7% (19/92), P=0.135] between PEG-rhG-CSF and rhG-CSF groups. ③There were no significant differences in terms of disease free survival (DFS) (62.5% vs 61.4%, P=0.478) and overall survival (OS) (67.4% vs 67.3%, P=0.718) between PEG-rhG-CSF and rhG-CSF groups. ④There was no significant difference of the non-relapse mortality (NRM) between PEG-rhG-CSF and rhG-CSF groups[20.5% (95%CI 11.4%–37.0%) vs 32.6% (95%CI 22.2%–47.9%), P=0.141]. …”
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    聚乙二醇化G-CSF与重组人G-CSF促进恶性血液病异基因造血干细胞移植后造血恢复的对比研究
  9. 485649
    “…The method was validated in patients with known or suspected cardiovascular disease, showing good agreement with conventional breath-held 2D LGE imaging, but offering higher spatial resolution, improved volumetric coverage and good image quality from a free-breathing acquisition with 100% scan efficiency and predictable scan time.…”
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    Motion-corrected 3D whole-heart water-fat high-resolution late gadolinium enhancement cardiovascular magnetic resonance imaging
  10. 485650
    “…Blood insulin, tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) levels were measured by enzyme-linked immunosorbent assay methods. Free fatty acids (FFAs) profiles in blood and liver were determined by using gas chromatography-mass spectrometry. …”
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    A high fat diet with a high C18:0/C16:0 ratio induced worse metabolic and transcriptomic profiles in C57BL/6 mice
  11. 485651
    “…EXPOSURES: Information was collected from citizens living in the quarantine zone (ie, red zone), area with restricted movements (ie, yellow zone), and COVID-19–free regions (ie, green zone). MAIN OUTCOMES AND MEASURES: Levels of knowledge on the virus, contagion-related worries, social appraisal, and preventive behaviors were assessed with ratings of quality of life (measured using the Short Form Health Survey). …”
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    Knowledge, Concerns, and Behaviors of Individuals During the First Week of the Coronavirus Disease 2019 Pandemic in Italy
  12. 485652
    “…METHODS: We conducted a 2×2×2×2 full factorial screening experiment wherein 864 participants were randomized to 1 of 16 experimental conditions after registering with a free internet smoking cessation program and enrolling in its automated text message program. …”
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    Optimizing Text Messages to Promote Engagement With Internet Smoking Cessation Treatment: Results From a Factorial Screening Experiment
  13. 485653
    “…During long-term follow-up, plasma total homocysteine (tHcy) levels were significantly higher in patients in the uncontrolled group than those in the seizure-free group. CONCLUSIONS: Most cblC patients caused by MMACHC c.609G > A homozygous mutation showed early-onset. …”
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    Variable phenotypes and outcomes associated with the MMACHC c.609G>A homologous mutation: long term follow-up in a large cohort of cases
  14. 485654
    “…However, understanding the efficacy of dietary interventions is confounded by the challenges inherent in assessing free living diet. Here we profiled dietary metabolites to investigate glycaemic deterioration and cardiometabolic risk in people at risk of or living with T2D. …”
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    Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study
  15. 485655
    “…The impact of the PD-1/PD-L1 expression alone and in combination with persistent tumor hypoxia on locoregional control (LRC), progression-free survival (PFS) and overall survival (OS) was examined using log-rank tests and Cox proportional hazards models. …”
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    Hypoxia dynamics on FMISO-PET in combination with PD-1/PD-L1 expression has an impact on the clinical outcome of patients with Head-and-neck Squamous Cell Carcinoma undergoing Chemoradiation
  16. 485656
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    Longitudinal profiles of plasma eicosanoids during pregnancy and size for gestational age at delivery: A nested case-control study
  17. 485657
    “…We determined the relationship of CSF NPTX2 levels to age, cognitive performance (CAMCOG, free and cued selective reminding, semantic verbal fluency), CSF levels of a PV-interneuron marker (GluA4) and core AD biomarkers; CSF Aβ(1–42), CSF t-tau, cortical atrophy (magnetic resonance imaging) and glucose metabolism ([(18)F]-fluorodeoxyglucose positron emission tomography). …”
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    Cerebrospinal fluid profile of NPTX2 supports role of Alzheimer’s disease-related inhibitory circuit dysfunction in adults with Down syndrome
  18. 485658
    “…Unsupervised hierarchical clustering of the copy number of genes residing in race-differentiated SCNAs shared between tumor types was used to identify SCNA-defined patient groups, and Cox proportional hazards regression was used to test for association between those groups and overall/progression-free survival (PFS). RESULTS: We identified SCNAs that differed by race in breast (n = 58 SCNAs; permutation p < 10(− 4)) and prostate tumors (n = 78 SCNAs; permutation p = 0.006). …”
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    Breast and prostate cancers harbor common somatic copy number alterations that consistently differ by race and are associated with survival
  19. 485659
    Publicado 2020
    “…The infection rates of CMV and EBV in the ATG-9 group (77.2% and 12.5%) were significantly higher than those in the ATG-6 (43.3% and 3.5%), and ATG-7.5 group (44.4% and 1.5%) (P<0.001 and P=0.033, respectively). ③Among the three groups, there were no significant difference in the 3-year overall survival [68.5% (95% CI 60.3%–77.9%), 60.1% (95% CI 48.3%–74.8%), 64.7% (95% CI 51.9%–80.7%)], cumulative incidences of relapse [34.6% (95% CI 34.3%–35.1%), 38.0% (95% CI 37.3%–38.7%), 20.6% (95% CI 20.0%–21.3%)], disease-free survival [53.3% (95% CI 44.9%–63.4%), 51.9% (95% CI 41%–65.8%), 63.9% (95% CI 51.9%–78.7%)] and non-relapse mortality [24.2% (95% CI 23.8%–24.5%), 26.0% (95% CI 25.4%–26.6%), 23.6% (95% CI 26.3%–28.2%)] (P=0.648, P=0.165, and P=0.486 and P=0.955). …”
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    恶性血液病单倍型造血干细胞移植预处理中兔抗人胸腺细胞球蛋白剂量优化探讨
  20. 485660
    “…Among 500 684 patients free of AF at baseline, standardized AF incidence rates from 2006 to 2018 increased from 4.74 (95% CI, 4.58-4.90) to 6.82 (95% CI, 6.65-7.00) cases per 1000 person-years, increasing significantly over time (P < .001). …”
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    Trends in Atrial Fibrillation Incidence Rates Within an Integrated Health Care Delivery System, 2006 to 2018
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