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485681por Xu, Chun-Wei, Wang, Wen-Xian, Wang, Dong, Wang, Qi-Ming, Pu, Xing-Xiang, Zhu, You-Cai, Huang, Jian-Hui, Yu, Zong-Yang, Cui, Zhao-Lei, Chen, Xiao-Hui, Li, Jin-Luan, Fang, Yong, Wang, Hong, Zhuang, Wu, Lan, Shi-Jie, Cai, Xin, Zhang, Yin-Bin, Gao, Wen-Bin, Wang, Li-Ping, She, Ke-Lin, Rao, Chuang-Zhou, Zhou, Yue-Fen, Fang, Mei-Yu, Miao, Li-Yun, Lei, Lei, Lv, Tang-Feng, Song, Yong“…Pemetrexed-based chemo-treated patients had longer median progression-free survival (PFS) than patients without pemetrexed-based chemo-treated (5.5 vs. 3.0 months, P=0.0026). …”
Publicado 2020
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485682por Tudor-Locke, Catrine, Ducharme, Scott W., Aguiar, Elroy J., Schuna, John M., Barreira, Tiago V., Moore, Christopher C., Chase, Colleen J., Gould, Zachary R., Amalbert-Birriel, Marcos A., Mora-Gonzalez, Jose, Chipkin, Stuart R., Staudenmayer, John“…Findings will need to be confirmed in older adults and in free-living settings. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12966-020-01045-z.…”
Publicado 2020
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485683por Shoepe, Todd C., LaBrie, Joseph W., Mello, Grant T., Leggett, Allison G., Almstedt, Hawley C.“…The second research aim evaluated the history of resistance training intensity on muscular strength, lean mass, and bone mineral density (BMD), RT participants were reassigned into a low- (LIRT) or high-intensity resistance training group (HIRT). 83 males and 87 females (19.3 ± 0.6 yrs., 171.1 ± 9.9 cm, 67.1 ± 10.5 kg, 22.9 ± 2.8 BMI, 26.2 ± 7.2% body fat) completed handgrip dynamometry (HG) and dual-energy x-ray absorptiometry scans (DXA) for BMD and bone mineral-free lean mass (BFLM). RESULTS: A 3-group method (NRT, LIRT, HIRT) reduced type-I error compared with the 2-group method (NRT, RT) in characterizing the likely effects of one’s history of resistance training. …”
Publicado 2020
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485684por Ang, Yvonne L. E., Ho, Gwo Fuang, Soo, Ross A., Sundar, Raghav, Tan, Sing Huang, Yong, Wei Peng, Ow, Samuel G. W., Lim, Joline S. J., Chong, Wan Qin, Soe, Phyu Pyar, Tai, Bee Choo, Wang, Lingzhi, Goh, Boon Cher, Lee, Soo-Chin“…Primary endpoints were objective-response (ORR:CR + PR) and clinical-benefit rate (CBR:CR + PR + SD); secondary endpoints were toxicity and progression-free-survival (PFS). RESULTS: We enrolled 68 patients from 2 study sites; 33 received docetaxel-sunitinib and 35 docetaxel alone, with 33 breast, 25 lung and 10 patients with other cancers. …”
Publicado 2020
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485685“…No significant differences were found between the two treatments in overall survival (OS) (HR = 0.95, 95% CI 0.76 ~ 1.18, P = 0.640), recurrence-free survival (RFS) (HR = 0.91, 95% CI 0.69 ~ 1.21, P = 0.530), and recurrence rate (OR = 0.90, 95% CI 0.67 ~ 1.21, P = 0.500). …”
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485686“…We carried out a meta-analysis on the HRs of overall survival (OS) and disease-free survival (DFS) to assess the prognostic value of TILs in breast cancer with different molecular subtypes more deeply. …”
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485687por Sambandam, Sankar, Mukhopadhyay, Krishnendu, Sendhil, Saritha, Ye, Wenlu, Pillarisetti, Ajay, Thangavel, Gurusamy, Natesan, Durairaj, Ramasamy, Rengaraj, Natarajan, Amudha, Aravindalochanan, Vigneswari, Vinayagamoorthi, A., Sivavadivel, S., Uma Maheswari, R., Balakrishnan, Lingeswari, Gayatri, S., Nargunanathan, Srinivasan, Madhavan, Sathish, Puttaswamy, Naveen, Garg, Sarada S., Quinn, Ashlinn, Rosenthal, Josh, Johnson, Michael, Liao, Jiawen, Steenland, Kyle, Piedhrahita, Ricardo, Peel, Jennifer, Checkley, William, Clasen, Thomas, Balakrishnan, Kalpana“…(i) cross-sectional measurements on women (N = 79) using either biomass or LPG as their primary cookfuel and (ii) before-and-after measurements on pregnant women (N = 41), once at baseline while using biomass fuel and twice – at 1 and 2 months – after installation of an LPG stove and free fuel intervention. We involved participants to co-design clothing and instrument stands for personal and area sampling. …”
Publicado 2020
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485688por Borghaei, Hossein, Langer, Corey J., Paz‐Ares, Luis, Rodríguez‐Abreu, Delvys, Halmos, Balazs, Garassino, Marina C., Houghton, Baerin, Kurata, Takayasu, Cheng, Ying, Lin, Jianxin, Pietanza, M. Catherine, Piperdi, Bilal, Gadgeel, Shirish M.“…Pembrolizumab plus chemotherapy improved overall survival (OS; hazard ratio [HR], 0.63; 95% CI, 0.50‐0.79) and progression‐free survival (HR, 0.68; 95% CI, 0.56‐0.83) over chemotherapy. …”
Publicado 2020
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485689por Albiges, Laurence, Tannir, Nizar M, Burotto, Mauricio, McDermott, David, Plimack, Elizabeth R, Barthélémy, Philippe, Porta, Camillo, Powles, Thomas, Donskov, Frede, George, Saby, Kollmannsberger, Christian K, Gurney, Howard, Grimm, Marc-Oliver, Tomita, Yoshihiko, Castellano, Daniel, Rini, Brian I, Choueiri, Toni K, Saggi, Shruti Shally, McHenry, M Brent, Motzer, Robert J“…Efficacy endpoints included overall survival (OS), progression-free survival (PFS) and objective response rate (ORR) per independent radiology review committee in patients with intermediate/poor-risk disease (I/P; primary), intent-to-treat patients (ITT; secondary) and in patients with favourable-risk disease (FAV; exploratory). …”
Publicado 2020
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485690por Jagust, Petra, Alcalá, Sonia, Sainz Jr, Bruno, Heeschen, Christopher, Sancho, Patricia“…Moreover, 3 of the upregulated genes (MGST1, GPX8, GCCT) were associated with reduced disease-free survival in patients [Hazard ratio (HR) 2.2-2.5; P = 0.03-0.0054], suggesting a critical role for this pathway in pancreatic cancer progression. …”
Publicado 2020
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485691por Song, Jiangdian, Wang, Lu, Ng, Nathan Norton, Zhao, Mingfang, Shi, Jingyun, Wu, Ning, Li, Weimin, Liu, Zaiyi, Yeom, Kristen W., Tian, Jie“…A deep learning (DL) semantic signature to predict progression-free survival (PFS) was constructed in the training cohort, validated in 2 external validation and 2 control cohorts, and compared with the radiomics signature. …”
Publicado 2020
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485692“…Individual PK parameters were simulated to describe free AMP time above the MIC(90) (fT >MIC(90)) of 32 mg/L. …”
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485693por Asundi, Archana, Billings, Nicole, Rogers, Zoe H, Roche, Samantha, Bombard, Jennifer, Kumcu, Michael E, Cunden, Lisa S, Nanayakkara, Imaly A, Tsui, Chiahao, Knysh, Paul, Maddux, Cabell, Munro, Zachary, Herriott, Ian, Huntley, Miriam, Lin, Nina H“…Day Zero Diagnostics has developed Blood2Bac(™), a culture-free, species agnostic process to enrich bacteria direct from whole blood. …”
Publicado 2020
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485694por Mack, Andrew R, Barnes, Melissa D, Taracila, Magdalena A, Mojica, Maria F, Kumar, Vijay, Rutter, Joseph, van den Akker, Focco, Page, Malcolm, Haider, Shozeb, Bonomo, Robert A“…Figure 1: (Left) We carried out enhanced sampling metadynamics simulations to generate free-energy landscapes as a function of the dihedral angles of residue 221. …”
Publicado 2020
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485695por Katsube, Takayuki, Kawaguchi, Nao, Matsunaga, Yuko, Ariyasu, Mari, Den Nagata, Tsutae, Portsmouth, Simon, Paterson, David, Paterson, David, Satlin, Michael J, Zeitlinger, Markus, Echols, Roger, Wajima, Toshihiro“…Percent time of dosing interval of free drug concentration exceeding the minimum inhibitory concentration (MIC) in plasma and epithelial lining fluid (ELF) (%fT(>MIC) and %fT(>MIC,ELF), respectively) were determined for 60 (CREDIBLE-CR; NCT02714595) and 97 patients (APEKS-NP; NCT03032380), using a 3-compartment population PK model. …”
Publicado 2020
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485696por Good, Steven S, Moussa, Adel, Zhou, Xiao-Jian, Sommadossi, Jean-Pierre, Pietropaolo, Keith“…Here we report the potent in vitro activity of AT-281, the free base form of AT-752, against Dengue virus and other flaviviruses and the in vivo efficacy of AT-752 in a mouse model of Dengue viral disease. …”
Publicado 2020
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485697por Aleksandrova, Krasimira, Reichmann, Robin, Kaaks, Rudolf, Jenab, Mazda, Bueno-de-Mesquita, H. Bas, Dahm, Christina C., Eriksen, Anne Kirstine, Tjønneland, Anne, Artaud, Fanny, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Hüsing, Anika, Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Panico, Salvatore, Masala, Giovanna, Grioni, Sara, Sacerdote, Carlotta, Tumino, Rosario, Elias, Sjoerd G., May, Anne M., Borch, Kristin B., Sandanger, Torkjel M., Skeie, Guri, Sánchez, Maria-Jose, Huerta, José María, Sala, Núria, Gurrea, Aurelio Barricarte, Quirós, José Ramón, Amiano, Pilar, Berntsson, Jonna, Drake, Isabel, van Guelpen, Bethany, Harlid, Sophia, Key, Tim, Weiderpass, Elisabete, Aglago, Elom K., Cross, Amanda J., Tsilidis, Konstantinos K., Riboli, Elio, Gunter, Marc J.“…METHODS: The model was based on data from 255,482 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) study aged 19 to 70 years who were free of cancer at study baseline (1992–2000) and were followed up to 31 September 2010. …”
Publicado 2021
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485698por Chang, Larry W., Mbabali, Ismail, Hutton, Heidi, Amico, K. Rivet, Kong, Xiangrong, Mulamba, Jeremiah, Anok, Aggrey, Ssekasanvu, Joseph, Long, Amanda, Thomas, Alvin G., Thomas, Kristin, Bugos, Eva, Pollard, Rose, van Wickle, Kimiko, Kennedy, Caitlin E., Nalugoda, Fred, Serwadda, David, Bollinger, Robert C., Quinn, Thomas C., Reynolds, Steven J., Gray, Ronald H., Wawer, Maria J., Nakigozi, GertrudeEnlace del recurso
Publicado 2021
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485699por Ricci, Fabrizio, Aung, Nay, Gallina, Sabina, Zemrak, Filip, Fung, Kenneth, Bisaccia, Giandomenico, Paiva, Jose Miguel, Khanji, Mohammed Y., Mantini, Cesare, Palermi, Stefano, Lee, Aaron M., Piechnik, Stefan K., Neubauer, Stefan, Petersen, Steffen E.“…METHODS: 5065 consecutive UK Biobank participants underwent CMR using cine balanced steady-state free precession imaging at 1.5 T. Participants with non-Caucasian ethnicity, prevalent cardiovascular disease and other conditions known to affect cardiac chamber size and function were excluded. …”
Publicado 2020
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485700por Dietrich, Janan J., Atujuna, Millicent, Tshabalala, Gugulethu, Hornschuh, Stefanie, Mulaudzi, Mamakiri, Koh, Michelle, Ahmed, Nadia, Muhumuza, Richard, Ssemata, Andrew S., Otwombe, Kennedy, Bekker, Linda-Gail, Seeley, Janet, Martinson, Neil A., Terris-Prestholt, Fern, Fox, Julie“…After discussions with experts and the study team, we revised the DCE to include the following five attributes and levels: dosing regime: daily, and on-demand PrEP; location: private pharmacy, public clinic, mobile clinic, ATM); cost: free-of-charge, R50 (~2GBP), R265 (~12GBP); side effects: nausea, headache, rash; and duration of protection: fulltime protection versus when PrEP is used). …”
Publicado 2021
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