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  1. 485861
    “…Meanwhile, the correlation between PAR1/PAR4 expression levels, clinicopathological characteristics, and disease free survival was analyzed. Then, we constructed PAR1/PAR4 knockdown cell models and investigated the role of PAR1/PAR4 knockdown on the proliferation, apoptosis, changes of calcium flow, and metastasis of ESCC cells via MTT, flow cytometry, transwell and wound healing assays in vitro. …”
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    PAR1 and PAR4 exert opposite effects on tumor growth and metastasis of esophageal squamous cell carcinoma via STAT3 and NF-κB signaling pathways
  2. 485862
    “…MAIN OUTCOMES AND MEASURES: The association of TACS(GC) with disease-free survival (DFS) and overall survival (OS) was assessed. …”
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    Association of Tumor-Associated Collagen Signature With Prognosis and Adjuvant Chemotherapy Benefits in Patients With Gastric Cancer
  3. 485863
    “…MAIN OUTCOMES AND MEASURES: The primary end point was 3-year disease-free survival (DFS). RESULTS: A total of 589 patients (median [IQR] age, 55 [47-52] years; 375 [63.7%] men and 214 [36.3%] women) were enrolled, including 294 patients randomized to the capecitabine with RT group and 295 patients randomized to the capecitabine and oxaliplatin with RT group. …”
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    Postoperative Chemoradiotherapy With Capecitabine and Oxaliplatin vs Capecitabine for Stage II to III Rectal Cancer: A Randomized Clinical Trial
  4. 485864
    “…METHODS: Data from a multicenter study on 133 patients treated with the anti-PD1 antibody nivolumab (July 2015–December 2016) were retrieved from a prospective database. Progression-free (PFS), overall survival (OS), incidence and severity of irAEs according to BMI categories were estimated by Kaplan–Meier method, landmark-analyses and Cox regressions. …”
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    Body mass index is not associated with survival outcomes and immune-related adverse events in patients with Hodgkin lymphoma treated with the immune checkpoint inhibitor nivolumab
  5. 485865
    “…Previously reported protein binding of 78.1% was used to define free exposure. Dose ranging studies were conducted on all STM to assess in vivo activity over a range of MIN exposures. …”
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    1103. Minocycline (MIN) Pharmacodynamics (PD) against Stenotrophomonas maltophilia (STM) in a Neutropenic Murine Thigh Infection Model
  6. 485866
    “…METHODS: LINE is the most popular messenger app in Japan; about 86 million people in Japan (roughly two-thirds of the population) use this messenger app. Corowa-kun, a free chatbot, was created in LINE on February 6, 2021. …”
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    439. Corowa-kun: Impact of a COVID-19 Vaccine Information Chatbot on Vaccine Hesitancy, Japan 2021
  7. 485867
    “…The prespecified exploratory endpoints included all-cause mortality and number of ventilator-free days (VFDs) through Day 28. RESULTS: Characteristics for 101 participants are shown in Table 1. …”
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    LB3. Baricitinib plus Standard of Care for Hospitalized Adults with COVID-19 on Invasive Mechanical Ventilation or Extracorporeal Membrane Oxygenation: Results of a Randomized, Placebo-Controlled Trial
  8. 485868
    “…BACKGROUND: HIV counseling and testing (HCT) is provided free of charge on college campuses, but very few studies have examined whether HCT uptake is equitably distributed. …”
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    Inequities in the utilization of HIV counseling and testing services among undergraduates in mainland China
  9. 485869
    “…Kaplan–Meier analysis was performed to estimate the progression-free survival (PFS) and overall survival (OS). Fisher exact test was used for categorical variables. …”
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    Correlation of circulating tumor DNA EGFR mutation levels with clinical outcomes in patients with advanced lung adenocarcinoma
  10. 485870
    “…Three subtests of RAVLT were used: RAVLT learning (RAVLT075), free-recall memory (RAVLT015), and recognition (RAVLT015R). …”
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    Toward Personalized Web-Based Cognitive Rehabilitation for Patients With Ischemic Stroke: Elo Rating Approach
  11. 485871
    “…METHODS: Ambulance accident data were collected from Austrian, German, and Swiss free web-based daily newspapers, as listed in Wikipedia, for the period between January 2014 and January 2019. …”
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    Online Newspaper Reports on Ambulance Accidents in Austria, Germany, and Switzerland: Retrospective Cross-sectional Review
  12. 485872
    “…MAIN OUTCOMES AND MEASURES: The main outcomes included overall survival (OS); subsequent-line, treatment-free survival (sTFS), defined as the period from metastasis to the date requiring subsequent-line treatment or death; and the survival to toxicity ratio (STR), defined as person-year rate of OS divided by person-year rate of severe hematologic toxic effects. …”
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    Treatment and Survival Outcomes Associated With Platinum Plus Low-Dose, Long-term Fluorouracil for Metastatic Nasopharyngeal Carcinoma
  13. 485873
    “…IRAK1 KO SCLL cells were xenografted into immunocompetent syngeneic mice where the typical rapid progression of disease was lost and the mice remained disease free. IRAK1 in this system has no effect on cell cycle progression or apoptosis and robust growth of the KO cells in immunodeficient mice suggested an effect on immune surveillance. …”
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    IRAK1-regulated IFN-γ signaling induces MDSC to facilitate immune evasion in FGFR1-driven hematological malignancies
  14. 485874
    “…In addition, body composition parameters will be assessed for a sub-set of children using bio-electrical impedance analysis on admission and at discharge to analyse changes in total body water, fat-free mass, and fat mass. Post discharge, all study participants will be followed up monthly until 6 months. …”
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    Effectiveness of community-based treatment programs for treatment of uncomplicated severe acute malnourished children aged 6–59 months using locally produced nutrient dense foods: protocol for a multicentric longitudinal quasi-experimental study
  15. 485875
    “…Of these, 95 patients from each group were analyzed, and their 5-year relapse-free survival (RFS) rates with and without oxaliplatin were 73.7 and 77.1%, respectively. …”
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    Evaluation of a 55-gene classifier as a prognostic biomarker for adjuvant chemotherapy in stage III colon cancer patients
  16. 485876
    por Haukvik, Unn K., Gurholt, Tiril P., Nerland, Stener, Elvsåshagen, Torbjørn, Akudjedu, Theophilus N., Alda, Martin, Alnæs, Dag, Alonso‐Lana, Silvia, Bauer, Jochen, Baune, Bernhard T., Benedetti, Francesco, Berk, Michael, Bettella, Francesco, Bøen, Erlend, Bonnín, Caterina M., Brambilla, Paolo, Canales‐Rodríguez, Erick J., Cannon, Dara M., Caseras, Xavier, Dandash, Orwa, Dannlowski, Udo, Delvecchio, Giuseppe, Díaz‐Zuluaga, Ana M., van Erp, Theo G. M., Fatjó‐Vilas, Mar, Foley, Sonya F., Förster, Katharina, Fullerton, Janice M., Goikolea, José M., Grotegerd, Dominik, Gruber, Oliver, Haarman, Bartholomeus C. M., Haatveit, Beathe, Hajek, Tomas, Hallahan, Brian, Harris, Mathew, Hawkins, Emma L., Howells, Fleur M., Hülsmann, Carina, Jahanshad, Neda, Jørgensen, Kjetil N., Kircher, Tilo, Krämer, Bernd, Krug, Axel, Kuplicki, Rayus, Lagerberg, Trine V., Lancaster, Thomas M., Lenroot, Rhoshel K., Lonning, Vera, López‐Jaramillo, Carlos, Malt, Ulrik F., McDonald, Colm, McIntosh, Andrew M., McPhilemy, Genevieve, van der Meer, Dennis, Melle, Ingrid, Melloni, Elisa M. T., Mitchell, Philip B., Nabulsi, Leila, Nenadić, Igor, Oertel, Viola, Oldani, Lucio, Opel, Nils, Otaduy, Maria C. G., Overs, Bronwyn J., Pineda‐Zapata, Julian A., Pomarol‐Clotet, Edith, Radua, Joaquim, Rauer, Lisa, Redlich, Ronny, Repple, Jonathan, Rive, Maria M., Roberts, Gloria, Ruhe, Henricus G., Salminen, Lauren E., Salvador, Raymond, Sarró, Salvador, Savitz, Jonathan, Schene, Aart H., Sim, Kang, Soeiro‐de‐Souza, Marcio G., Stäblein, Michael, Stein, Dan J., Stein, Frederike, Tamnes, Christian K., Temmingh, Henk S., Thomopoulos, Sophia I., Veltman, Dick J., Vieta, Eduard, Waltemate, Lena, Westlye, Lars T., Whalley, Heather C., Sämann, Philipp G., Thompson, Paul M., Ching, Christopher R. K., Andreassen, Ole A., Agartz, Ingrid
    Publicado 2020
    “…T1‐weighted magnetic resonance imaging scans from 4,698 individuals (BD = 1,472, healthy controls [HC] = 3,226) from 23 sites worldwide were processed with FreeSurfer. We used linear mixed‐effects models and mega‐analysis to investigate differences in hippocampal subfield volumes between BD and HC, followed by analyses of clinical characteristics and medication use. …”
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    In vivo hippocampal subfield volumes in bipolar disorder—A mega‐analysis from The Enhancing Neuro Imaging Genetics through Meta‐Analysis Bipolar Disorder Working Group
  17. 485877
    “…The level of circCHST15 was positively correlated with aggressive clinicopathological characteristics, and circCHST15 served as an independent prognostic indicator for overall survival and progression-free survival in patients with ccRCC after surgical resection. …”
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    circCHST15 is a novel prognostic biomarker that promotes clear cell renal cell carcinoma cell proliferation and metastasis through the miR-125a-5p/EIF4EBP1 axis
  18. 485878
    “…The median progression-free survival time was 18.25 months in the HAS group, which was shorter than that in the non-HAS group (72.96 months; P = 0.001). …”
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    Computed Tomography Features and Clinical Prognostic Characteristics of Hepatoid Adenocarcinoma of the Stomach
  19. 485879
    “…Kaplan–Meier plots were conducted to evaluate the effect of GADVR on progression-free survival (PFS). RESULTS: Compared with non-GADVR tumor thrombus, patients with GADVR tumor thrombus had a higher proportion of open surgery (76.2% vs. 52.1%, P = 0.035), a higher proportion of tumor thrombus adhering to the inferior vena cava (IVC) vessel wall (81% vs. 45.8%, P = 0.002), a higher proportion of segmental resection of the IVC vessel wall (61.9% vs. 15.6%, P < 0.001); higher preoperative serum creatinine value (110.0 μmol/L vs. 91.0 μmol/L, P = 0.015), a higher proportion of tumor thrombus combined with bland thrombus (non-tumor thrombus) (57.1% vs. 19.8%, P < 0.001). …”
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    Renal cell carcinoma with tumor thrombus growing against the direction of venous return: an indicator of complicated surgery and poor prognosis
  20. 485880
    “…Exercise resulted in better performance in timed‐up‐and‐go (6.3 vs. 7.1 s, P = 0.05) and timed‐stand‐test (18 vs. 14 repetitions, P < 0.01) compared with RYGB. Fat‐free mass was lower (POST9‐PRE) after RYBG than RYGB + ET (total: −7.9 vs. −4.9 kg, P < 0.01; lower‐limb: −3.8 vs. −2.7 kg, P = 0.02). …”
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    A randomized clinical trial on the effects of exercise on muscle remodelling following bariatric surgery
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