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  1. 486001
    “…Size metrics investigated were total body weight, fat and fat-free mass. Theory-based allometry was used to scale pharmacokinetic parameters to a 70 kg individual. …”
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    Population Pharmacokinetic Modelling of Acetaminophen and Ibuprofen: the Influence of Body Composition, Formulation and Feeding in Healthy Adult Volunteers
  2. 486002
    “…Here we assess the contribution of polygenic risk scores (PRSs) to the occurrence of extreme phenotypes with respect to age at onset, namely, primary BC diagnosis before the age of 35 years (early diagnosis, ED) and cancer-free survival until the age of 60 years (late/no diagnosis, LD) in female BRCA1/2 PV carriers. …”
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    Polygenic risk scores indicate extreme ages at onset of breast cancer in female BRCA1/2 pathogenic variant carriers
  3. 486003
    “…RESULTS: For the base-case, VN resulted in incremental costs per patient of CHF 764’402 (VN: CHF 901’654, SoC: CHF 137’252), incremental blindness-free years of 7.67 (VN: 28.32, SoC: 20.65) and incremental QALYs of 6.73 (VN: 18.35, SoC: 11.62), leading to an incremental cost-effectiveness ratio of CHF 113’526 per QALY gained. …”
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    Cost-effectiveness of voretigene neparvovec in the treatment of patients with inherited retinal disease with RPE65 mutation in Switzerland
  4. 486004
    “…In addition, the overall survival (OS) and progression‐free survival (PFS) rates among PD‐L1 inhibitor managed sufferers were acquired through a follow‐up visit. …”
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    Serum exosomal miR‐16‐5p functions as a tumor inhibitor and a new biomarker for PD‐L1 inhibitor‐dependent immunotherapy in lung adenocarcinoma by regulating PD‐L1 expression
  5. 486005
    “…Although current guidelines encourage people living with HIV (PLWH) to take COVID-19 vaccines, whether their immune response to COVID-19 vaccines is distinct from HIV-free individuals is still unclear. METHODS: Between March to June 2021, 48 PLWH and 40 HNC, aged 18 to 59 years, were enrolled in the study in Wuchang district of Wuhan city. …”
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    Immune response and safety to inactivated COVID-19 vaccine: a comparison between people living with HIV and HIV-naive individuals
  6. 486006
    “…Separation of leukocytes and cell-free supernatant of a bronchoalveolar lavagate by centrifugation revealed that carbon black was completely located in the cell sediment, indicating total engulfment by alveolar macrophages. …”
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    Toxicokinetics of Nanoparticles Deposited in Lungs Using Occupational Exposure Scenarios
  7. 486007
    “…By POM12, 25 (83.3%) eyes were medication-free. Three (10%) eyes had stent occlusion by iris requiring laser iridoplasty. …”
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    Prospective 12-month outcomes of combined iStent inject implantation and phacoemulsification in Asian eyes with normal tension glaucoma
  8. 486008
    por Bhave, Prachi, Ahmed, Tasnia, Lo, Serigne N, Shoushtari, Alexander, Zaremba, Anne, Versluis, Judith M, Mangana, Joanna, Weichenthal, Michael, Si, Lu, Lesimple, Thierry, Robert, Caroline, Trojanello, Claudia, Wicky, Alexandre, Heywood, Richard, Tran, Lena, Batty, Kathleen, Dimitriou, Florentia, Stansfeld, Anna, Allayous, Clara, Schwarze, Julia K, Mooradian, Meghan J, Klein, Oliver, Mehmi, Inderjit, Roberts-Thomson, Rachel, Maurichi, Andrea, Yeoh, Hui-Ling, Khattak, Adnan, Zimmer, Lisa, Blank, Christian U, Ramelyte, Egle, Kähler, Katharina C, Roy, Severine, Ascierto, Paolo A, Michielin, Olivier, Lorigan, Paul C, Johnson, Douglas B, Plummer, Ruth, Lebbe, Celeste, Neyns, Bart, Sullivan, Ryan, Hamid, Omid, Santinami, Mario, McArthur, Grant A, Haydon, Andrew M, Long, Georgina V, Menzies, Alexander M, Carlino, Matteo S
    Publicado 2022
    “…Primary outcome was objective response rate (ORR); secondary outcomes were progression-free survival (PFS) and overall survival (OS). RESULTS: In total, 325 patients were included: 234 (72%) plantar, 69 (21%) subungual and 22 (7%) palmar primary sites. …”
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    Efficacy of anti-PD-1 and ipilimumab alone or in combination in acral melanoma
  9. 486009
    “…The median progression-free survival was 18.0 months, and the median overall survival for all patients was not reached. …”
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    Four-year follow-up of LCAR-B38M in relapsed or refractory multiple myeloma: a phase 1, single-arm, open-label, multicenter study in China (LEGEND-2)
  10. 486010
    “…METHODS: Sixty cadets (43 males, 17 females; 20.9 ± 3.8 years; 173.6 ± 10.2 cm; 75.6 ± 13.7 kg) completed the 6-event ACFT (3-repetition maximum trap-bar deadlift [3DL], standing power toss [SPT], hand-release pushups [HRPU], sprint-drag-carry shuttle run [SDC], leg tuck [LTK], or plank [PLK], and 2-mile run [2MR]), body composition analysis via dual-energy x-ray absorptiometry (percent body fat [%BF], lean body mass [LBM], fat-free mass index [FFMI (LBM+bone mineral content)]), and an omega-3 questionnaire. …”
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    Body Composition, Eicosapentaenoic Acid, and Vitamin D are Associated with Army Combat Fitness Test Performance
  11. 486011
    “…BACKGROUND: Patients with V600BRAF mutant metastatic melanoma have higher rates of progression-free survival (PFS) and overall survival (OS) with first-line anti-PD1 (PD1]+anti-CTLA-4 (IPI) versus PD1. …”
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    Efficacy and safety of anti-PD1 monotherapy or in combination with ipilimumab after BRAF/MEK inhibitors in patients with BRAF mutant metastatic melanoma
  12. 486012
    “…Wechat public platform has built a bridge for communication between teachers and students and realized free dialogue between teachers and students. Therefore, the platform has become an oral English training base. …”
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    RESEARCH ON THE IMPLEMENTATION AND PRACTICE OF WECHAT PUBLIC PLATFORM TEACHING RESOURCES BASED ON PSYCHOLOGICAL AND EMOTIONAL REGULATION — TAKING PRIMARY SCHOOL FOREIGN LANGUAGE (ENGLISH) CURRICULUM AS AN EXAMPLE
  13. 486013
    “…Detection of CTCs at any follow-up visit was significantly predictive of worse disease-free survival (DFS;hazard ratio [HR]: 2.44; 95% confidence interval [CI]: 1.41-4.24; p=0.002), regional control (HR: 6.18; 95% CI: 1.18-32.35; p=0.031), distant control (HR: 2.93; 95% CI: 1.52-5.65;p=0.001) and overall survival (OS;HR: 2.02; 95% CI: 1.16-3.51; p=0.013). …”
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    Circulating tumor cells detected in follow-up predict survival outcomes in tri-modality management of advanced non-metastatic esophageal cancer: a secondary analysis of the QUINTETT randomized trial
  14. 486014
    “…The optimized strategy was further used to compare the phosphoproteomes of the lung cancer cells with different metastatic abilities. Label-free quantification proteomics demonstrated that 510, 863, and 1108 phosphorylated proteins were identified from normal lung fibroblasts (MRC-5), low metastatic lung cancer cells (95C), and high metastatic lung cancer cells (95D), respectively, using the optimized Ti(4+)-IMAC method. …”
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    基于亲和色谱的肺癌细胞磷酸化蛋白质组研究及其应用
  15. 486015
    “…In recent years, human umbilical cord mesenchymal stem cells (huc-MSCs)-derived exosomes have been used to relieve neuropathic pain and other inflammatory diseases as a promising cell-free therapeutic strategy. However, the therapeutic value of huc-MSCs-derived exosomes in complete Freund's adjuvant (CFA)-induced inflammatory pain remains to be confirmed. …”
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    Huc-MSCs-derived exosomes attenuate inflammatory pain by regulating microglia pyroptosis and autophagy via the miR-146a-5p/TRAF6 axis
  16. 486016
    por Ward, Sarah V., Burton, Anya, Tamimi, Rulla M., Pereira, Ana, Garmendia, Maria Luisa, Pollan, Marina, Boyd, Norman, dos-Santos-Silva, Isabel, Maskarinec, Gertraud, Perez-Gomez, Beatriz, Vachon, Celine, Miao, Hui, Lajous, Martín, López-Ridaura, Ruy, Bertrand, Kimberly, Kwong, Ava, Ursin, Giske, Lee, Eunjung, Ma, Huiyan, Vinnicombe, Sarah, Moss, Sue, Allen, Steve, Ndumia, Rose, Vinayak, Sudhir, Teo, Soo-Hwang, Mariapun, Shivaani, Peplonska, Beata, Bukowska-Damska, Agnieszka, Nagata, Chisato, Hopper, John, Giles, Graham, Ozmen, Vahit, Aribal, Mustafa Erkin, Schüz, Joachim, Van Gils, Carla H., Wanders, Johanna O. P., Sirous, Reza, Sirous, Mehri, Hipwell, John, Kim, Jisun, Lee, Jong Won, Dickens, Caroline, Hartman, Mikael, Chia, Kee-Seng, Scott, Christopher, Chiarelli, Anna M., Linton, Linda, Flugelman, Anath Arzee, Salem, Dorria, Kamal, Rasha, McCormack, Valerie, Stone, Jennifer
    Publicado 2022
    “…METHODS: Participants were 10,681 breast-cancer-free women from 22 countries in the International Consortium of Mammographic Density, each with centrally assessed mammographic density and a common set of epidemiologic data. …”
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    The association of age at menarche and adult height with mammographic density in the International Consortium of Mammographic Density
  17. 486017
    “…Endpoints were overall-survival (OS), progression-free-survival (PFS), and cumulative incidences of isolated loco-regional failures, distant metastases, secondary tumors as well as non-cancer deaths within the first year. …”
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    Long-term survival of patients with central or > 7 cm T4 N0/1 M0 non-small-cell lung cancer treated with definitive concurrent radiochemotherapy in comparison to trimodality treatment
  18. 486018
    por Fallah, Aria, Lewis, Evan, Ibrahim, George M., Kola, Olivia, Tseng, Chi‐Hong, Harris, William B., Chen, Jia‐Shu, Lin, Kao‐Min, Cai, Li‐Xin, Liu, Qing‐Zhu, Lin, Jiu‐Luan, Zhou, Wen‐Jing, Mathern, Gary W., Smyth, Matthew D., O'Neill, Brent R., Dudley, Roy W. R., Ragheb, John, Bhatia, Sanjiv, Delev, Daniel, Ramantani, Georgia, Zentner, Josef, Wang, Anthony C., Dorfer, Christian, Feucht, Martha, Czech, Thomas, Bollo, Robert J., Issabekov, Galymzhan, Zhu, Hongwei, Connolly, Mary, Steinbok, Paul, Zhang, Jian‐Guo, Zhang, Kai, Hidalgo, Eveline Teresa, Weiner, Howard L., Wong‐Kisiel, Lily, Lapalme‐Remis, Samuel, Tripathi, Manjari, Sarat Chandra, Poodipedi, Hader, Walter, Wang, Feng‐Peng, Yao, Yi, Champagne, Pierre‐Olivier, Brunette‐Clément, Tristan, Guo, Qiang, Li, Shao‐Chun, Budke, Marcelo, Pérez‐Jiménez, Maria Angeles, Raftopoulos, Christian, Finet, Patrice, Michel, Pauline, Schaller, Karl, Stienen, Martin N., Baro, Valentina, Cantillano Malone, Christian, Pociecha, Juan, Chamorro, Noelia, Muro, Valeria L., von Lehe, Marec, Vieker, Silvia, Oluigbo, Chima, Gaillard, William D., Al‐Khateeb, Mashael, Al Otaibi, Faisal, Krayenbühl, Niklaus, Bolton, Jeffrey, Pearl, Phillip L., Weil, Alexander G.
    Publicado 2021
    “…Log‐rank test found that vertical hemispherotomy was associated with durable seizure‐free progression compared to the lateral approach (p = .01). …”
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    Comparison of the real‐world effectiveness of vertical versus lateral functional hemispherotomy techniques for pediatric drug‐resistant epilepsy: A post hoc analysis of the HOPS study
  19. 486019
    “…Overall survival (OS), progression-free survival (PFS), objective response rate (ORR) were evaluated by modified Response Evaluation Criteria in Solid Tumors criteria, and safety profiles were compared between the two groups. …”
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    Lenvatinib with or without Concurrent Drug-Eluting Beads Transarterial Chemoembolization in Patients with Unresectable, Advanced Hepatocellular Carcinoma: A Real-World, Multicenter, Retrospective Study
  20. 486020
    “…INTRODUCTION: Several clinical trials comparing the efficacy and safety of transarterial chemoembolization (TACE) plus molecular-targeted agents versus TACE alone revealed no clinical benefits in progression-free survival (PFS) or overall survival (OS). Here, we report the final OS analysis from the TACTICS trial, which previously demonstrated significant improvement in PFS with TACE plus sorafenib in patients with unresectable hepatocellular carcinoma (HCC) (NCT01217034). …”
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    Final Results of TACTICS: A Randomized, Prospective Trial Comparing Transarterial Chemoembolization Plus Sorafenib to Transarterial Chemoembolization Alone in Patients with Unresectable Hepatocellular Carcinoma
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