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  1. 486061
    por Gounder, Mrinal M., Razak, Albiruni Abdul, Somaiah, Neeta, Chawla, Sant, Martin-Broto, Javier, Grignani, Giovanni, Schuetze, Scott M., Vincenzi, Bruno, Wagner, Andrew J., Chmielowski, Bartosz, Jones, Robin L., Riedel, Richard F., Stacchiotti, Silvia, Loggers, Elizabeth T., Ganjoo, Kristen N., Le Cesne, Axel, Italiano, Antoine, Garcia del Muro, Xavier, Burgess, Melissa, Piperno-Neumann, Sophie, Ryan, Christopher, Mulcahy, Mary F., Forscher, Charles, Penel, Nicolas, Okuno, Scott, Elias, Anthony, Hartner, Lee, Philip, Tony, Alcindor, Thierry, Kasper, Bernd, Reichardt, Peter, Lapeire, Lore, Blay, Jean-Yves, Chevreau, Christine, Valverde Morales, Claudia Maria, Schwartz, Gary K., Chen, James L., Deshpande, Hari, Davis, Elizabeth J., Nicholas, Garth, Gröschel, Stefan, Hatcher, Helen, Duffaud, Florence, Herráez, Antonio Casado, Beveridge, Roberto Diaz, Badalamenti, Giuseppe, Eriksson, Mikael, Meyer, Christian, von Mehren, Margaret, Van Tine, Brian A., Götze, Katharina, Mazzeo, Filomena, Yakobson, Alexander, Zick, Aviad, Lee, Alexander, Gonzalez, Anna Estival, Napolitano, Andrea, Dickson, Mark A., Michel, Dayana, Meng, Changting, Li, Lingling, Liu, Jianjun, Ben-Shahar, Osnat, Van Domelen, Dane R., Walker, Christopher J., Chang, Hua, Landesman, Yosef, Shah, Jatin J., Shacham, Sharon, Kauffman, Michael G., Attia, Steven
    Publicado 2022
    “…The primary end point was progression-free survival (PFS). Patients who received at least one dose of study treatment were included for safety analysis (ClinicalTrials.gov identifier: NCT02606461). …”
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    Selinexor in Advanced, Metastatic Dedifferentiated Liposarcoma: A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial
  2. 486062
    “…BACKGROUND: Natural language processing (NLP) methods are powerful tools for extracting and analyzing critical information from free-text data. MedTaggerIE, an open-source NLP pipeline for information extraction based on text patterns, has been widely used in the annotation of clinical notes. …”
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    Multicenter Validation of Natural Language Processing Algorithms for the Detection of Common Data Elements in Operative Notes for Total Hip Arthroplasty: Algorithm Development and Validation
  3. 486063
    “…RESULTS: At follow-up, employees in the intervention condition were more likely to report increased sleep duration on work (7.20 vs 6.99, p=0.01) and on free (8.26 vs 8.04, p=0.03) nights. At follow-up, the prevalence of poor sleep quality was lower in the intervention (n=160 of 321, 50%) compared with control (n=184 of 327, 56%) (p=0.04). …”
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    Evaluating the impact of a sleep health education and a personalised smartphone application on sleep, productivity and healthcare utilisation among employees: results of a randomised clinical trial
  4. 486064
    “…The second aim is to evaluate the accuracy of IMUs for quantifying the sagittal plane FJA overground in comparison to bi-dimensional (2-D) optical motion capture (OMC). 14 horses (7 free from lameness and 7 lame) were enrolled and analyzed with both systems at walk and trot on a firm surface. …”
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    Fetlock Joint Angle Pattern and Range of Motion Quantification Using Two Synchronized Wearable Inertial Sensors per Limb in Sound Horses and Horses with Single Limb Naturally Occurring Lameness
  5. 486065
    “…The Atherosclerotic Cardiovascular Disease (ASCVD) score was calculated to estimate 10-year risk of cardiovascular disease or stroke and the diabetes lifetime-perspective prediction (DIAL) score was calculated to estimate years free of cardiovascular disease. RESULTS: Six months after replacing exogenous insulin by DMR and GLP-1RA, visceral adipose tissue decreased significantly by 24%. …”
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    Eliminating exogenous insulin therapy in patients with type 2 diabetes by duodenal ablation and GLP-1RA decreases risk scores for cardiovascular events
  6. 486066
    “…Median OS was 11.5 (10–22.3) months from start of VEN when subsequent alloHSCT was carried out. Relapse-free survival (RFS) for the total cohort was 10.2 (2.2 – 24.3) months. …”
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    Clinical experience with venetoclax in patients with newly diagnosed, relapsed, or refractory acute myeloid leukemia
  7. 486067
    “…No significant differences were observed between the groups in terms of overall survival (HR = 0.63; 95% CI 0.24 to 1.67; P = 0.852) or recurrence-free survival (HR = 0.29; 95% CI 0.03 to 2.67; P = 0.900). …”
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    Pathological and oncological outcomes of pylorus-preserving versus conventional distal gastrectomy in early gastric cancer: a systematic review and meta-analysis
  8. 486068
    “…A total of 6-week-old pathogen-free, female BALB/c mice, weighing 20-25 g were used for all animal experiments. …”
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    P010 Evaluation of antifungal efficacy of two novel cyclic lipopeptides of the class Bacillomycin from Bacillus subtilis RLID 12.1 in a murine model of invasive candidiasis
  9. 486069
    “…Supernatant was collected at 12 h, 24 h, 48 h, 72 h, 96 h, and 120 h of incubation and evaluated for antibacterial activity by agar-well diffusion assay. Effect of cell-free supernatant of Malassezia on growth of bacteria was also monitored by growth kinetics of S. epidermidis for 24 h in the absence and presence of M. furfur supernatant using Epoch-2 microplate spectrophotometer. …”
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    P105 In vitro interaction of Malassezia and commensal Staphylococcus species
  10. 486070
    “…Besides that, there are difficulties in handling sick cats, lack of diagnosis of human and veterinary cases, and poor access to free medication. In 2011, the first case of CTS was identified in Curitiba, Paraná, Brazil. …”
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    P138 A decade of cat-transmitted sporotrichosis (CTS) in a tertiary hospital from Curitiba, southern Brazil (2011-21)
  11. 486071
    “…S3.4 FREE ORAL PAPER SESSION, SEPTEMBER 21, 2022, 4:45 PM - 6:15 PM:   OBJECTIVES: Making fluconazole (FLC) fungicidal in combination with adjuvants is a promising strategy to avoid the emergence of FLC resistance and eliminate the persistence and recurrence of fungal infections. …”
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    S3.4a The repurposing approach identifies pitavastatin (calcium) making fluconazole fungicidal by inhibiting ergosterol synthesis
  12. 486072
    “…Grindr provides an option to disclose current PrEP use (HIV positive, HIV negative, or HIV negative with PrEP use). The free text in all profiles was analyzed, and any mention of COVID-19 vaccination was recorded. …”
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    Engagement With HIV and COVID-19 Prevention: Nationwide Cross-sectional Analysis of Users on a Geosocial Networking App
  13. 486073
    “…Together, our data suggest that co-targeting TIGIT may prevent CAR T relapses and thus promote long-term progression-free survival in MCL patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12943-022-01655-0.…”
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    TIGIT is the central player in T-cell suppression associated with CAR T-cell relapse in mantle cell lymphoma
  14. 486074
    “…METHODS AND FINDINGS: This study included 93,110 participants (24 to 60 years old; 11.6% male) from the Nurses’ Health Study (NHS), NHSII, and Health Professionals Follow-Up Study (HPFS) cohorts who were free of T2D, cardiovascular disease, and cancer at baseline (1988 for NHS/HPFS and 1989 for NHSII) for analyses of weight change and 104,180 (24 to 78 years old; 14.2% male) for T2D risk assessment. …”
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    Weight loss strategies, weight change, and type 2 diabetes in US health professionals: A cohort study
  15. 486075
    por Ecclestone, Tegwen, Merry, Peter
    Publicado 2022
    “…Serum protein electrophoresis showed paraprotein bands with abnormal serum free light chain assay possibly consistent with myeloma, lymphoma or MGUS. …”
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    P21 The fly in the ointment: a rare cause of cytopaenia
  16. 486076
    “…Combined hazard ratios (HRs) for overall survival (OS) and progression-free survival (PFS) were calculated using fixed- or random-effects models based on heterogeneity. …”
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    Patients with melanoma treated with immune checkpoint inhibitors who had non-thyroid endocrine and skin immune-related adverse events have better prognosis: A systematic review and meta-analysis
  17. 486077
    “…S5.4 FREE ORAL PAPER SESSION, SEPTEMBER 22, 2022, 3:00 PM - 4:30 PM:   OBJECTIVE: Recent genome-wide genotype-phenotype association studies (GWAS) of sets of clinical fungal isolates have reported problems resulting from strong phylogenetic clustering (apparent quasi-clonal population structure, difficulties in localizing association signals on chromosomes). …”
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    S5.4b Genomic variation structure in clinical isolate collections alters benefits of association screening: a study of Cryptococcus neoformans var. grubii in Colombia
  18. 486078
    “…The 5-year progression-free survival (PFS) of the patients with primary intraosseous RDD was 57.5%. …”
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    Primary intraosseous Rosai–Dorfman disease: An analysis of clinicopathologic characteristics, molecular genetics, and prognostic features
  19. 486079
    “…Secondary outcomes included changes in body composition (fat mass, fat-free mass, and percentage of body weight), resting energy expenditure, and adaptive thermogenesis. …”
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    Effect of a Personalized Diet to Reduce Postprandial Glycemic Response vs a Low-fat Diet on Weight Loss in Adults With Abnormal Glucose Metabolism and Obesity: A Randomized Clinical Trial
  20. 486080
    “…The intensification of malaria prevention and control through the free distribution of insecticide-treated nets in recent years may have altered the composition, geographic distribution and natural infection rate of Anopheles species, with implications for malaria transmission dynamics. …”
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    Diversity and behavioral activity of Anopheles mosquitoes on the slopes of Mount Cameroon
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