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  1. 486381
    “…MAIN OUTCOMES AND MEASURES: Progression-free survival (PFS) and overall survival (OS), estimated by Kaplan-Meier curves, and continuous variables compared by t test or Mann-Whitney test. …”
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    Safety, Antitumor Activity, and Pharmacokinetics of Toripalimab, a Programmed Cell Death 1 Inhibitor, in Patients With Advanced Non–Small Cell Lung Cancer: A Phase 1 Trial
  2. 486382
    “…On Feb 6, 2018, median follow-up was 62·9 months (IQR 58·1–74·1). 434 (10%) of 4480 women had a breast cancer recurrence (280 [9%] POAI; 154 [10%] control), hazard ratio 0·92 (95% CI 0·75–1·12); p=0·40 with the proportion free from breast cancer recurrence at 5 years of 91·0% (95% CI 89·9–92·0) for patients in the POAI group and 90·4% (88·7–91·9) in the control group. …”
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    Long-term outcome and prognostic value of Ki67 after perioperative endocrine therapy in postmenopausal women with hormone-sensitive early breast cancer (POETIC): an open-label, multicentre, parallel-group, randomised, phase 3 trial
  3. 486383
    “…LV diastolic velocity TDI peaks were significantly associated with hypertransaminasemia (p < 0.05) and tended to be associated with a low all body Fat-Free Mass Index (FFMI) (using Dual-energy X- ray Absorptiometry (DXA) (HOLOGICQDR 4500) (p = 0.056). …”
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    Echocardiographic abnormalities in 124 severely malnourished adult anorexia nervosa patients: frequency and relationship with body composition and biological features
  4. 486384
    “…The ROS-related injury reduces fertilization potential and adversely affects the sperm DNA integrity. Antioxidants act as free radical scavengers to protect spermatozoa against ROS induced damage. …”
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    Antioxidant pretreatment for male partner before ART for male factor subfertility: a randomized controlled trial
  5. 486385
    “…ROC analysis was used to determine the optimal cut-off values of ∆SUV% to distinguish LRs from non-LRs and LSs from non-LSs. Progression-free survival (PFS) and overall survival (OS) were estimated by Kaplan–Meier method. …”
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    Early Changes of the Standardized Uptake Values (SUV(max)) Predict the Efficacy of Everolimus-Exemestane in Patients with Hormone Receptor-Positive Metastatic Breast Cancer
  6. 486386
    “…Despite the commitments of the government to assure home free delivery, majority of the births in Sub-Saharan Africa are attended by traditional birth attendants. …”
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    Pooled prevalence and determinants of skilled birth attendant delivery in East Africa countries: a multilevel analysis of Demographic and Health Surveys
  7. 486387
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    Evaluating the relationship between alcohol consumption, tobacco use, and cardiovascular disease: A multivariable Mendelian randomization study
  8. 486388
    “…Documentation of RP care and an 80-character, free-text comment were shared between WIC and PCPs. …”
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    Advanced Health Information Technologies to Engage Parents, Clinicians, and Community Nutritionists in Coordinating Responsive Parenting Care: Descriptive Case Series of the Women, Infants, and Children Enhancements to Early Healthy Lifestyles for Baby (WEE Baby) Care Randomized Controlled Trial
  9. 486389
    por Bon, Giulia, Pizzuti, Laura, Laquintana, Valentina, Loria, Rossella, Porru, Manuela, Marchiò, Caterina, Krasniqi, Eriseld, Barba, Maddalena, Maugeri-Saccà, Marcello, Gamucci, Teresa, Berardi, Rossana, Livi, Lorenzo, Ficorella, Corrado, Natoli, Clara, Cortesi, Enrico, Generali, Daniele, La Verde, Nicla, Cassano, Alessandra, Bria, Emilio, Moscetti, Luca, Michelotti, Andrea, Adamo, Vincenzo, Zamagni, Claudio, Tonini, Giuseppe, Barchiesi, Giacomo, Mazzotta, Marco, Marinelli, Daniele, Tomao, Silverio, Marchetti, Paolo, Valerio, Maria Rosaria, Mirabelli, Rosanna, Russo, Antonio, Fabbri, Maria Agnese, D’Ostilio, Nicola, Veltri, Enzo, Corsi, Domenico, Garrone, Ornella, Paris, Ida, Sarobba, Giuseppina, Giotta, Francesco, Garufi, Carlo, Cazzaniga, Marina, Del Medico, Pietro, Roselli, Mario, Sanguineti, Giuseppe, Sperduti, Isabella, Sapino, Anna, De Maria, Ruggero, Leonetti, Carlo, Di Leo, Angelo, Ciliberto, Gennaro, Falcioni, Rita, Vici, Patrizia
    Publicado 2020
    “…Among the 371 patients treated with second-line T-DM1, median overall survival (mOS) from diagnosis of advanced disease and median progression-free survival to second-line treatment (mPFS2) were 52 and 6 months in 177 patients who received trastuzumab/pertuzumab in first-line, and 74 and 10 months in 194 pertuzumab-naïve patients (p = 0.0006 and 0.03 for OS and PFS2, respectively). …”
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    Loss of HER2 and decreased T-DM1 efficacy in HER2 positive advanced breast cancer treated with dual HER2 blockade: the SePHER Study
  10. 486390
    por Jehan, Fyezah, Sazawal, Sunil, Baqui, Abdullah H., Nisar, Muhammad Imran, Dhingra, Usha, Khanam, Rasheda, Ilyas, Muhammad, Dutta, Arup, Mitra, Dipak K., Mehmood, Usma, Deb, Saikat, Mahmud, Arif, Hotwani, Aneeta, Ali, Said Mohammed, Rahman, Sayedur, Nizar, Ambreen, Ame, Shaali Makame, Moin, Mamun Ibne, Muhammad, Sajid, Chauhan, Aishwarya, Begum, Nazma, Khan, Waqasuddin, Das, Sayan, Ahmed, Salahuddin, Hasan, Tarik, Khalid, Javairia, Rizvi, Syed Jafar Raza, Juma, Mohammed Hamad, Chowdhury, Nabidul Haque, Kabir, Furqan, Aftab, Fahad, Quaiyum, Abdul, Manu, Alexander, Yoshida, Sachiyo, Bahl, Rajiv, Rahman, Anisur, Pervin, Jesmin, Winston, Jennifer, Musonda, Patrick, Stringer, Jeffrey S. A., Litch, James A., Ghaemi, Mohammad Sajjad, Moufarrej, Mira N., Contrepois, Kévin, Chen, Songjie, Stelzer, Ina A., Stanley, Natalie, Chang, Alan L., Hammad, Ghaith Bany, Wong, Ronald J., Liu, Candace, Quaintance, Cecele C., Culos, Anthony, Espinosa, Camilo, Xenochristou, Maria, Becker, Martin, Fallahzadeh, Ramin, Ganio, Edward, Tsai, Amy S., Gaudilliere, Dyani, Tsai, Eileen S., Han, Xiaoyuan, Ando, Kazuo, Tingle, Martha, Marić, Ivana, Wise, Paul H., Winn, Virginia D., Druzin, Maurice L., Gibbs, Ronald S., Darmstadt, Gary L., Murray, Jeffrey C., Shaw, Gary M., Stevenson, David K., Snyder, Michael P., Quake, Stephen R., Angst, Martin S., Gaudilliere, Brice, Aghaeepour, Nima
    Publicado 2020
    “…Plasma samples were assayed for targeted measurement of proteins and untargeted cell-free ribonucleic acid profiling; urine samples were assayed for metabolites. …”
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    Multiomics Characterization of Preterm Birth in Low- and Middle-Income Countries
  11. 486391
    “…In the real-world setting, no statistically significant differences in long-term outcomes with P vs PCT were observed; a prospective randomized trial addressing the comparative efficacy of P and PCT in different patient subgroups is highly anticipated.List of abbreviations: AE - adverse events; ALK - anaplastic lymphoma kinase gene; ALT - alanine aminotransferase; (a)NSCLC - (advanced) non-small cell lung cancer; AST - aspartate aminotransferase; BRAF - v-Raf murine sarcoma viral oncogene homolog B; BRCA2 - BReast CAncer gene 2; c-Met - tyrosine-protein kinase Met; CTCAE, v. 4.03 - Common Terminology Criteria for Adverse Events, version 4.03; CTLA-4 - cytotoxic T-lymphocyte-associated protein 4; ECOG PS - Eastern Cooperative Oncology Group performance status; EGFR - epidermal growth factor receptor gene; FISH - fluorescent in situ hybridization; HER2 - human epidermal growth factor receptor 2; IC - tumor-infiltrating immune cells; ICI - immune check-point inhibitors; IHC - immunohistochemistry; IQR - interquartile range; irAE - immune related adverse events; ISCORT - Israeli Society for Clinical Oncology and Radiotherapy; KRAS - Kirsten rat sarcoma viral oncogene homolog; (m)TTD -(median) time-to-treatment discontinuation; mo - months; (m)OS - (median) overall survival; (m)PFS - (median) progression-free survival; muts/Mb - mutations per megabase; NA - not specified/not available; NOS - not otherwise specified; NR - not reported/not reached; ORR - objective response rate; P - pembrolizumab; PCR - polymerase chain reaction; PCT - combination of pembrolizumab with platinum-based chemotherapy; PD – progression of disease; PD-1 - programmed cell death-1; PD-L1 - programmed cell death ligand-1; pts - patients; RET - proto-oncogene RET; ROS1 - proto-oncogene tyrosine-protein kinase ROS1; SD - standard deviation; STK11 - serine/threonine kinase 11; TC - tumor cells; TMB - Tumor mutation burden; TPS - tumor proportion score.…”
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    Pembrolizumab as a monotherapy or in combination with platinum-based chemotherapy in advanced non-small cell lung cancer with PD-L1 tumor proportion score (TPS) ≥50%: real-world data
  12. 486392
    por Côté, Pierre, Hartvigsen, Jan, Axén, Iben, Leboeuf-Yde, Charlotte, Corso, Melissa, Shearer, Heather, Wong, Jessica, Marchand, Andrée-Anne, Cassidy, J. David, French, Simon, Kawchuk, Gregory N., Mior, Silvano, Poulsen, Erik, Srbely, John, Ammendolia, Carlo, Blanchette, Marc-André, Busse, Jason W., Bussières, André, Cancelliere, Carolina, Christensen, Henrik Wulff, De Carvalho, Diana, De Luca, Katie, Du Rose, Alister, Eklund, Andreas, Engel, Roger, Goncalves, Guillaume, Hebert, Jeffrey, Hincapié, Cesar A., Hondras, Maria, Kimpton, Amanda, Lauridsen, Henrik Hein, Innes, Stanley, Meyer, Anne-Laure, Newell, David, O’Neill, Søren, Pagé, Isabelle, Passmore, Steven, Perle, Stephen M., Quon, Jeffrey, Rezai, Mana, Stupar, Maja, Swain, Michael, Vitello, Andrew, Weber, Kenneth, Young, Kenneth J., Yu, Hainan
    Publicado 2021
    “…SYSTEMATIC REVIEW OF THE LITERATURE: We searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, the Cumulative Index to Nursing and Allied Health, and the Index to Chiropractic Literature from inception to May 15, 2019 using subject headings specific to each database and free text words relevant to manipulation/manual therapy, effectiveness, prevention, treatment, and non-musculoskeletal disorders. …”
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    The global summit on the efficacy and effectiveness of spinal manipulative therapy for the prevention and treatment of non-musculoskeletal disorders: a systematic review of the literature
  13. 486393
    “…Secondary outcomes were sum of skinfold thickness (SST), fat mass index (FMI) and fat-free mass index (FFMI). We used multivariable regression analyses (adjusting for maternal lifestyle and sociodemographic factors) to assess the associations of maternal DASH and E-DII scores with offspring adiposity outcomes in cohort-specific analyses, with subsequent random-effect meta-analyses. …”
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    Maternal dietary quality, inflammatory potential and childhood adiposity: an individual participant data pooled analysis of seven European cohorts in the ALPHABET consortium
  14. 486394
    “…We used content analysis of free text responses among providers reporting increased stress, anxiety or depression. …”
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    Mental health among outpatient reproductive health care providers during the US COVID-19 epidemic
  15. 486395
    “…The pathogenicity of the wild-bird-origin NDV sub-genotype VII.1.1 NDV strains were assessed by experimental inoculation of identified strains (KFS-Motobas-2, KFS-Elhamoul-1, and KFS-Elhamoul-3) in 28-day-old specific-pathogen-free (SPF) Cobb chickens. The clinical signs and post-mortem changes of velogenic NDV genotype VII (GVII) were observed in inoculated chickens 3 to 7 days post-inoculation, with 67.5–70% mortality rates. …”
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    Molecular Characterization of Velogenic Newcastle Disease Virus (Sub-Genotype VII.1.1) from Wild Birds, with Assessment of Its Pathogenicity in Susceptible Chickens
  16. 486396
    por van der Kooi, Anne-Lotte L F, van Dijk, Marloes, Broer, Linda, van den Berg, Marleen H, Laven, Joop S E, van Leeuwen, Flora E, Lambalk, Cornelis B, Overbeek, Annelies, Loonen, Jacqueline J, van der Pal, Helena J, Tissing, Wim J, Versluys, Birgitta, Bresters, Dorine, Beerendonk, Catharina C M, Ronckers, Cécile R, van der Heiden-van der Loo, Margriet, Kaspers, Gertjan L, de Vries, Andrica C H, Robison, Leslie L, Hudson, Melissa M, Chemaitilly, Wassim, Byrne, Julianne, Berger, Claire, Clemens, Eva, Dirksen, Uta, Falck Winther, Jeanette, Fosså, Sophie D, Grabow, Desiree, Haupt, Riccardo, Kaiser, Melanie, Kepak, Tomas, Kruseova, Jarmila, Modan-Moses, Dalit, Pluijm, Saskia M F, Spix, Claudia, Zolk, Oliver, Kaatsch, Peter, Krijthe, Jesse H, Kremer, Leontien C, Yasui, Yutaka, Brooke, Russell J, Uitterlinden, André G, van den Heuvel-Eibrink, Marry M, van Dulmen-den Broeder, Eline
    Publicado 2021
    “…VU 2006-3622) and by the Children Cancer Free Foundation (Project no. 20) and the St Jude Lifetime cohort study by NCI U01 CA195547. …”
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    Possible modification of BRSK1 on the risk of alkylating chemotherapy-related reduced ovarian function
  17. 486397
    por Cortellini, Alessio, Di Maio, Massimo, Nigro, Olga, Leonetti, Alessandro, Cortinovis, Diego L, Aerts, Joachim GJV, Guaitoli, Giorgia, Barbieri, Fausto, Giusti, Raffaele, Ferrara, Miriam G, Bria, Emilio, D'Argento, Ettore, Grossi, Francesco, Rijavec, Erika, Guida, Annalisa, Berardi, Rossana, Torniai, Mariangela, Sforza, Vincenzo, Genova, Carlo, Mazzoni, Francesca, Garassino, Marina Chiara, De Toma, Alessandro, Signorelli, Diego, Gelibter, Alain, Siringo, Marco, Marchetti, Paolo, Macerelli, Marianna, Rastelli, Francesca, Chiari, Rita, Rocco, Danilo, Della Gravara, Luigi, Inno, Alessandro, Michele, De Tursi, Grassadonia, Antonino, Di Marino, Pietro, Mansueto, Giovanni, Zoratto, Federica, Filetti, Marco, Santini, Daniele, Citarella, Fabrizio, Russano, Marco, Cantini, Luca, Tuzi, Alessandro, Bordi, Paola, Minuti, Gabriele, Landi, Lorenza, Ricciardi, Serena, Migliorino, Maria R, Passiglia, Francesco, Bironzo, Paolo, Metro, Giulio, Adamo, Vincenzo, Russo, Alessandro, Spinelli, Gian Paolo, Banna, Giuseppe L, Friedlaender, Alex, Addeo, Alfredo, Cannita, Katia, Ficorella, Corrado, Porzio, Giampiero, Pinato, David J
    Publicado 2021
    “…On the multivariable analysis, ATB emerged as a strong predictor of worse overall survival (OS) (HR=1.42 (95% CI 1.13 to 1.79); p=0.0024), and progression free survival (PFS) (HR=1.29 (95% CI 1.04 to 1.59); p=0.0192) in the pembrolizumab but not in the chemotherapy cohort. …”
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    Differential influence of antibiotic therapy and other medications on oncological outcomes of patients with non-small cell lung cancer treated with first-line pembrolizumab versus cytotoxic chemotherapy
  18. 486398
    “…BACKGROUND: In March 2020, Text4Hope—a community health service—was provided to Alberta residents. This free service aims to promote psychological resilience and alleviate pandemic-associated stress, anxiety, and depression symptoms during the COVID-19 pandemic. …”
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    Gender Differences in Satisfaction With a Text Messaging Program (Text4Hope) and Anticipated Receptivity to Technology-Based Health Support During the COVID-19 Pandemic: Cross-sectional Survey Study
  19. 486399
    “…Greater improvements with semaglutide 2.4 mg vs placebo were also seen in waist circumference, BMI, systolic blood pressure, fasting plasma glucose, C-reactive protein, and lipids (HDL, VLDL, free fatty acids, and triglycerides) (p<0.05 for all). …”
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    Efficacy and Safety of Semaglutide 2.4 MG Once-Weekly in Adults With Overweight or Obesity and Type 2 Diabetes (STEP 2)
  20. 486400
    “…Herein we present our early experience with this protocol in six normally-cycling, non-hyperandrogenic women: median (range) age 23.1 (19.8–29.0) years, body mass index 20.7 (19.2–27.2) kg/m2, calculated serum free testosterone 2.7 (2.4–5.3) pg/ml. Study subjects began transdermal E2 on cycle day 4 with the following dose-escalation protocol: 0.2 mg/d x 1 day, then 0.3 mg/d x 1 day, then 0.4 mg/d x 1 day, then 0.5 mg/d. …”
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    Assessment of Estradiol-Induced Gonadotropin Surge Generation: Preliminary Results From a Protocol of Graded Transdermal Estradiol Dosing
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