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  1. 5181
    “…The recent advances in relative protein–ligand binding free energy calculations have shown the value of alchemical methods in drug discovery. …”
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    Alchemical absolute protein–ligand binding free energies for drug design
  2. 5182
    “…The effects of DNASE1L3 or DNASE1 deficiency on cell-free DNA (cfDNA) methylation were explored in plasma of mice deficient in these nucleases and in DNASE1L3-deficient humans. …”
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    Nuclease deficiencies alter plasma cell-free DNA methylation profiles
  3. 5183
    “…CONCLUSION: Successful reconstruction was performed using ALT free flaps for large anterior skull base defects. …”
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    Anterior skull base reconstruction using an anterolateral thigh free flap
  4. 5184
    “…The objective of this study was to examine the relationship between group A Streptococcus (GAS) throat culture testing and antibiotic prescriptions at 10 free clinics in the Tampa Bay Area serving the uninsured population. …”
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    Treatment of Pharyngitis in Uninsured Patients: A Multicenter Study of Free Clinics
  5. 5185
    por Westerterp, Klaas R, Yamada, Yosuke, Sagayama, Hiroyuki, Ainslie, Philip N, Andersen, Lene F, Anderson, Liam J, Arab, Lenore, Baddou, Issaad, Bedu-Addo, Kweku, Blaak, Ellen E, Blanc, Stephane, Bonomi, Alberto G, Bouten, Carlijn V C, Bovet, Pascal, Buchowski, Maciej S, Butte, Nancy F, Camps, Stefan G J A, Close, Graeme L, Cooper, Jamie A, Das, Sai K, Cooper, Richard, Dugas, Lara R, Ekelund, Ulf, Entringer, Sonja, Forrester, Terrence, Fudge, Barry W, Goris, Annelies H, Gurven, Michael, Hambly, Catherine, El Hamdouchi, Asmaa, Hoos, Marije B, Hu, Sumei, Joonas, Noorjehan, Joosen, Annemiek M, Katzmarzyk, Peter, Kempen, Kitty P, Kimura, Misaka, Kraus, William E, Kushner, Robert F, Lambert, Estelle V, Leonard, William R, Lessan, Nader, Martin, Corby K, Medin, Anine C, Meijer, Erwin P, Morehen, James C, Morton, James P, Neuhouser, Marian L, Nicklas, Theresa A, Ojiambo, Robert M, Pietiläinen, Kirsi H, Pitsiladis, Yannis P, Plange-Rhule, Jacob, Plasqui, Guy, Prentice, Ross L, Rabinovich, Roberto A, Racette, Susan B, Raichlen, David A, Ravussin, Eric, Reynolds, Rebecca M, Roberts, Susan B, Schuit, Albertine J, Sjödin, Anders M, Stice, Eric, Urlacher, Samuel S, Valenti, Giulio, Van Etten, Ludo M, Van Mil, Edgar A, Wells, Jonathan C K, Wilson, George, Wood, Brian M, Yanovski, Jack, Yoshida, Tsukasa, Zhang, Xueying, Murphy-Alford, Alexia J, Loechl, Cornelia U, Luke, Amy H, Pontzer, Herman, Rood, Jennifer, Schoeller, Dale A, Wong, William W, Speakman, John R
    Publicado 2021
    “…BACKGROUND: Physical activity may be a way to increase and maintain fat-free mass (FFM) in later life, similar to the prevention of fractures by increasing peak bone mass. …”
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    Physical activity and fat-free mass during growth and in later life
  6. 5186
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    Breastfeeding versus free distribution of infant formulas by the Public Health System
  7. 5187
    por Kappen, Mitchel, Naber, Marnix
    Publicado 2021
    “…These findings mark the necessity and usefulness of novel, bias-free, and scientific approaches to candidate and employee screening and selection procedures in recruitment and human resources.…”
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    Objective and bias-free measures of candidate motivation during job applications
  8. 5188
    “…Interestingly, these non-isocyanate polyurethanes (NIPUs) with ferroelectric properties could be successfully synthesized using a solvent-free reactive extrusion process on the basis of an aminolysis reaction between resorcinol bis-carbonate and different diamine extension agents. …”
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    Solvent-Free Design of Biobased Non-isocyanate Polyurethanes with Ferroelectric Properties
  9. 5189
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    Z-DNA as a Tool for Nuclease-Free DNA Methyltransferase Assay
  10. 5190
    “…To rationalize these findings by the distinct lipid compositions, we computed ~200 free energies of stalk formation in membranes with different lipid head groups, tail lengths, tail unsaturations, and sterol content. …”
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    Free energies of membrane stalk formation from a lipidomics perspective
  11. 5191
    “…In contrast to diffusion metrics derived from the single-compartment model, no relationship was seen between iron and the free water compartment in substantia nigra.…”
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    Nigral diffusivity, but not free water, correlates with iron content in Parkinson’s disease
  12. 5192
    “…Emerging noninvasive optical technologies such as reflectance confocal microscopy (RCM) can provide label-free, cellular-level resolution, in vivo images of skin without performing a biopsy. …”
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    Biopsy-free in vivo virtual histology of skin using deep learning
  13. 5193
    “…Here we introduce a new class of wireless battery-free devices, named osseosurface electronics, which feature soft mechanics, ultra-thin form factor and miniaturized multimodal biointerfaces comprised of sensors and optoelectronics directly adhered to the surface of the bone. …”
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    Osseosurface electronics—thin, wireless, battery-free and multimodal musculoskeletal biointerfaces
  14. 5194
    “…To address this gap, we asked if social integration and social status in free-ranging rhesus macaques (Macaca mulatta) predict anatomical and physiological markers of immunity. …”
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    Sociality predicts individual variation in the immunity of free-ranging rhesus macaques
  15. 5195
    “…To further improve this approach, [Formula: see text] ‐conforming finite elements can be used to obtain exactly divergence‐free velocity solutions. We present several new finite element discretizations. …”
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    Divergence‐free tangential finite element methods for incompressible flows on surfaces
  16. 5196
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    DNAzyme-Amplified Label-Free Biosensor for the Simple and Sensitive Detection of Pyrophosphatase
  17. 5197
    por Guedj, Benjamin, Pujol, Louis
    Publicado 2021
    “…“No free lunch” results state the impossibility of obtaining meaningful bounds on the error of a learning algorithm without prior assumptions and modelling, which is more or less realistic for a given problem. …”
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    Still No Free Lunches: The Price to Pay for Tighter PAC-Bayes Bounds
  18. 5198
    “…Free light chains (FLC) are a promising biomarker to detect intrathecal inflammation in patients with inflammatory central nervous system (CNS) diseases, including multiple sclerosis (MS). …”
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    The Increasing Role of Kappa Free Light Chains in the Diagnosis of Multiple Sclerosis
  19. 5199
    “…Therefore, using liquid chromatography–tandem mass spectrometry, we assessed the levels of several neuroactive steroids in various brain areas and the plasma of germ-free (GF) male mice and conventionally colonized controls. …”
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    Exploring the Impact of the Microbiome on Neuroactive Steroid Levels in Germ-Free Animals
  20. 5200
    “…To tackle these issues, a data-driven model-free adaptive controller is proposed in this paper which guarantees stability and the desired performance of the inverter in the presence of uncertainties. …”
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    Data-Driven Model-Free Adaptive Control of Z-Source Inverters
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