“…Our study presents novel mammalian cell-free system for eccDNA generation. Using purified protein extract we show that eccDNA formation does not involve de-novo DNA synthesis suggesting that eccDNA is generated through excision of chromosomal sequences. …”
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“…BACKGROUND: Direct observations of underwater behaviour of free-living marine mammals are rare. This is particularly true for large and potentially dangerous species such as the walrus (Odobenus rosmarus). …”
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“…RESULTS: We propose a Distribution Free Convolution Model (DFCM) to circumvent observed deficiencies in meeting and validating distribution assumptions of parametric methods. …”
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“…Here, we report a general, substrate-free platform for HTS that overcomes this problem by monitoring the reaction of broad-spectrum, activity-based probes with enzymes using fluorescence polarization. …”
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“…CONCLUSION: PKQuest_Java is a free, easy to use, interactive PBPK software routine. …”
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“…Because most of the phenytoin in serum is bound to proteins, the level of serum albumin influences the amount of free phenytoin. MATERIALS AND METHODS: We compared the measured and calculated free phenytoin levels in epileptic patients who were taking phenytoin monotherapy, using the Sheiner-Tozer equation. …”
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“…In order to overcome some of these limitations, we propose a Stochastic Context Free Grammar based framework for the analysis of protein sequences where grammars are induced using a genetic algorithm. …”
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“…A free radial forearm fascial flap has been described for intraoral reconstruction. …”
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“…OBJECTIVES: Exposure to second-hand smoke (SHS) is widespread in restaurants in Ulaanbaatar, the capital city of Mongolia. While a smoke-free policy is the most effective way of protecting restaurant workers and customers from SHS, this has not been well accepted in Mongolia. …”
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“…PCR-based methods may underestimate mutation frequencies of heterogeneous tumor genomes. Using a novel PCR-free random cloning/sequencing method, we analyzed 100 kb of total genomic DNA from blood lymphocytes, normal prostate and tumor prostate taken from six individuals. …”
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“…Label-free LC-MS analysis allows determining the differential expression level of proteins in multiple samples, without the use of stable isotopes. …”
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“…The aim of the present paper was to evaluate the genotypic diversity of S. mutans in caries-free and caries-active preschool children in Brazil. …”
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“…In a solvent-free phase-vanishing reaction with PTFE (polytetrafluoroethylene, Teflon(®)) tape as the phase screen, a thermometer adapter is utilized to insert a PTFE-sealed tube into the vapor phase above the substrate. …”
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“…The free osteocutaneous fibula flap is an established method of reconstruction of maxillary and mandibular defects. …”
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“…Low energy output and possible fattening mechanisms are expected, as either an adaptive response to drastic seasonal fluctuations of food supplies in Madagascar, or persisting traits from previously nocturnal hypometabolic ancestors. Free ranging ring-tailed lemurs (Lemur catta) and brown lemurs (Eulemur sp.) of southern Madagascar have different socio-ecological characteristics which allow a test of these theories: Both gregarious primates have a phytophagous diet but different circadian activity rhythms, degree of arboreality, social systems, and slightly different body size. …”
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“…In the present study, we report the effect of chloroform extracts of Calotropis gigantea leaf and flower on free radical scavenging activity, and lipid profile in streptozotozin-induced diabetic rats. …”
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“…Here, we present a novel, alignment-free approach for using conservation information for TF binding site discovery. …”
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