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  1. 221
    por Aznab, Mozaffar, Khazaei, Mansour
    Publicado 2016
    “…This case report has presented an evidence of the development Stevens - Johnson syndrome associated with combination chemotherapy administration of 5FU, gemcitabin and cisplatin in a patient with biliary tract cancer. …”
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    Stevens-Johnson Syndrome Patient Received Combination Chemotherapy Gemcitabine, Cisplatin, and 5-FU for Biliary Tract Cancer
  2. 222
    “…Chronic hypoxia suppressed the expression of cyclinD1, CDK4, and CDK6, inducing G1 phase block and 5-flurouracil (5-FU) chemoresistance. Overexpression of c-Myc reversed the inhibition of cyclinD1, CDK4, and CDK6, which accelerated the G1/S phase transition under hypoxia and enhanced sensitivity to 5-FU. …”
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    c-Myc is regulated by HIF-2α in chronic hypoxia and influences sensitivity to 5-FU in colon cancer
  3. 223
    “…The present data suggested that DKK4 may enhance the resistance of colorectal cancer cells to 5-Fu and YN968D1 treatment, when used alone or in combination.…”
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    DKK4 enhances resistance to chemotherapeutics 5-Fu and YN968D1 in colorectal cancer cells
  4. 224
    “…Furthermore, we found that the intracellular concentration of 5-FU was elevated by miR-3190-5p, and consequently the sensitivity of CRC cells to 5-FU was also enhanced. …”
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    A polymorphism in ABCC4 is related to efficacy of 5-FU/capecitabine-based chemotherapy in colorectal cancer patients
  5. 225
    “…The 5-fluorouracil (5-FU) treatment induces DNA damage and stalling of DNA replication forks. …”
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    NSC30049 inhibits Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations
  6. 226
    “…Conclusions: HES1 promotes chemoresistance to 5-Fu by prompting EMT and inducing of several ABC transporter genes. …”
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    HES1 Promotes Colorectal Cancer Cell Resistance To 5-Fu by Inducing Of EMT and ABC Transporter Proteins
  7. 227
    “…BACKGROUND: Chronic heart AQ4 failure (CHF) is the final stage of various heart diseases. YiQiFuMai injection (YQFMI) has been widely applied in the treatment of CHF. …”
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    YiQiFuMai injection for chronic heart failure: Protocol for a systematic review and meta-analysis
  8. 228
    “…Here, we investigated whether over-activation of AKT pathway is important in the resistance to 5-fluorouracil (5-FU) in SNU-C5/5-FU cells, 5-FU-resistant human colon cancer cells. …”
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    Over-activation of AKT signaling leading to 5-Fluorouracil resistance in SNU-C5/5-FU cells
  9. 229
    “…BEL-7402/5-FU reflected high resistance to 5-FU; PACC and PADF could promote drug accumulation in BEL-7402/5-FU cells, among which PADF was more effective than PACC. …”
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    The Effects and Mechanisms of Periplaneta americana Extract Reversal of Multi-Drug Resistance in BEL-7402/5-FU Cells
  10. 230
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    People with Dementia in Sub-Saharan Africa: From Support to Abuse by Caregivers: Results of EPIDEMCA-FU Program in Congo
  11. 231
    “…Dihydropyrimidine dehydrogenase (DPD) is the major enzyme in the catabolism of 5-Fluorouracil (5-FU) and its prodrug capecitabine. We report a 65-year-old female with rectal adenocarcinoma who experienced severe toxicities secondary to standard dose 5-FU based chemotherapy. …”
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    Identifying a Novel DPYD Polymorphism Associated with Severe Toxicity to 5-FU Chemotherapy in a Saudi Patient
  12. 232
    “…Context: Shenqi FuZheng injection (SFI) has been suggested as a complementary treatment of chemotherapy in China. …”
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    ShenQi FuZheng injection as an adjunctive treatment to chemotherapy in breast cancer patients: a meta-analysis
  13. 233
    “…The small molecule drug 5-fluorouracil (5-FU) is widely used in the treatment for gastric cancer (GC), however, it exerts poor efficacy and is associated with acquired and intrinsic resistance. …”
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    Inhibition of protein FAK enhances 5-FU chemosensitivity to gastric carcinoma via p53 signaling pathways
  14. 234
    “…Herein, we found that 5-FU increased gastric cancer-derived exosomal PD-L1. …”
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    5-FU-Induced Upregulation of Exosomal PD-L1 Causes Immunosuppression in Advanced Gastric Cancer Patients
  15. 235
    “…Further investigations demonstrated that overexpression of ZFP36 inhibited tumor growth and promoted 5-Fu sensitivity in xenograft tumor mice model, which could be reversed when PRC1 overexpressed simultaneously. …”
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    ZFP36 Binds With PRC1 to Inhibit Tumor Growth and Increase 5-Fu Chemosensitivity of Hepatocellular Carcinoma
  16. 236
    “…Compound Fu Brick Tea (CFBT), which is from Duyun city in China, is a traditional Chinese dark tea, Fu Brick Tea, mixed with six herbal medicine. …”
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    Compound Fu brick tea modifies the intestinal microbiome composition in high‐fat diet‐induced obesity mice
  17. 237
    “…The role of differentially expressed long non-coding RNA (lncRNA) in 5-fluorouracil (5-Fu) resistance has not been fully elucidated. Here we observed that lncRNA NEAT1 was associated with 5-Fu resistance in CRC. …”
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    LncRNA NEAT1 remodels chromatin to promote the 5-Fu resistance by maintaining colorectal cancer stemness
  18. 238
    “…We describe and evaluate a novel white-box fuzzer for C programs named FuSeBMC, which combines fuzzing and symbolic execution, and applies Bounded Model Checking (BMC) to find security vulnerabilities in C programs. …”
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    FuSeBMC: A White-Box Fuzzer for Finding Security Vulnerabilities in C Programs (Competition Contribution)
  19. 239
    por Chu, Huaizhu, Han, Nahui, Xu, Jianguo
    Publicado 2021
    “…UMP/CMP kinase is responsible for the phosphorylation of the ribonucleotide metabolite 5-fluoro-5′-monophosphate (FUMP) in 5-FU metabolic process, and recognized as a key step in the conversion of 5-FU to cytotoxic metabolites. …”
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    CMPK1 Regulated by miR-130b Attenuates Response to 5-FU Treatment in Gastric Cancer
  20. 240
    “…More importantly, WT161 showed synergistic inhibition with 5-FU on osteosarcoma cells in vitro and in vivo. Conclusions: These results indicate that WT161 inhibits the growth of osteosarcoma through PTEN and has a synergistic efficiency with 5-FU.…”
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    HDAC6 inhibitor WT161 performs anti-tumor effect on osteosarcoma and synergistically interacts with 5-FU
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