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261“…The effects of treatment with 5-FU/folinic acid on interleukin-2 related lymphocyte responses was investigated in 21 patients with advanced colorectal cancer. …”
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262por Nakano, J, Huang, C, Liu, D, Masuya, D, Nakashima, T, Yokomise, H, Ueno, M, Wada, H, Fukushima, M“…The sensitivity to 5-fluorouracil (5-FU) has been reported to be associated with target molecule thymidylate synthase (TS), fluoropyrimidine-metabolising enzymes such as orotate phosphoribosyltransferase (OPRT), and dihydropyrimidine dehydrogenase (DPD). …”
Publicado 2006
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263por Saunders, M P, Hogg, M, Carrington, B, Sjursen, A-M, Allen, J, Beech, J, Swindell, R, Valle, J W“…This single-centre phase I trial was designed to determine the maximum tolerated dose of irinotecan and the recommended dose to use in combination with a fixed dose of 5-fluorouracil (5-FU) administered as a protracted venous infusion, for the first-line treatment of metastatic colorectal cancer (CRC). …”
Publicado 2004
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264por Wagner, A D, Buechner-Steudel, P, Moehler, M, Schmalenberg, H, Behrens, R, Fahlke, J, Wein, A, Behl, S, Kuss, O, Kleber, G, Fleig, W E“…BACKGROUND: Gemcitabine, oxaliplatin and 5-fluorouracil (5-FU) are active in biliary tract cancer and have a potentially synergistic mode of action and non-overlapping toxicity. …”
Publicado 2009
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265“…The aim of this study was to evaluate the predictive value of the polymorphism Glutathione S-transferase P1 (GSTP1) Ile(105)Val on oxaliplatin/5-FU-based chemotherapy in advanced gastric cancer. …”
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266por McIntyre, Dominick J. O., Howe, Franklyn A., Ladroue, Christophe, Lofts, Fiona, Stubbs, Marion, Griffiths, John R.“…Previous studies have shown better survival associated with longer 5FU tumour half-life. This work investigated 5FU pharmacokinetics in liver metastases of colorectal cancer. …”
Publicado 2010
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267por Nagata, M, Nakayama, H, Tanaka, T, Yoshida, R, Yoshitake, Y, Fukuma, D, Kawahara, K, Nakagawa, Y, Ota, K, Hiraki, A, Shinohara, M“…BACKGROUND: Resistance to 5-fluorouracil (5-FU) is a major obstacle in treating oral squamous cell carcinoma (OSCC). …”
Publicado 2011
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268por Park, Ji Soo, Lim, Jae Yun, Park, Seung Kyo, Kim, Min Kyung, Ko, Hee Sung, Yoon, Sun Och, Kim, Jong Won, Choi, Seung Ho, Cho, Jae Yong“…Arm A was defined as 5-fluorouracil (5-FU)+cisplatin (FP) or folinic acid, 5-FU and oxaliplati (FOLFOX), followed by folinic acid, 5-FU and irinotecan (FOLFIRI), and paclitaxel or docetaxel plus 5-FU, with or without epirubicin. …”
Publicado 2011
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269por Wehler, Thomas C., Hamdi, Swaantje, Maderer, Annett, Graf, Claudine, Gockel, Ines, Schmidtmann, Irene, Hainz, Michael, Berger, Martin R., Theobald, Matthias, Galle, Peter R., Moehler, Markus, Schimanski, Carl C.“…Interestingly, treatment with either sorafenib or 5-FU resulted in a significant decrease of VEGFR1 and PDGFRβ expression intensity. …”
Publicado 2012
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270“…Functional assays demonstrated that HuR and FOXO1 expression levels were markedly enhanced upon 5-fluorouracil (5-FU) stimulation in MDA-MB-231 cells. Knockdown of HuR apparently abrogated 5-FU-induced apoptosis detected by caspase-3 activities. …”
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271por Wang, Jingbo, Wang, Xu, Zhao, Mingjue, Choo, Su Pin, Ong, Sin Jen, Ong, Simon Y. K., Chong, Samuel S., Teo, Yik Ying, Lee, Caroline G. L.“…5-Fluorouracil (5-FU) and its pro-drug Capecitabine have been widely used in treating colorectal cancer. …”
Publicado 2014
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272por ITOH, YOSHIYUKI, IKEDA, MITSURU, HIRASAWA, NAOKI, ISHIHARA, SHUNICHI, OKUDA, TAKAHITO, MURAO, TAKAYUKI, KUBOTA, SEIJI, OKADA, TOHRU, NAGANAWA, SHINJI, ISHIGAKI, TAKEO“…We conducted a retrospective comparison of the hemotoxicity of the sequential administration of 5-Fluorouracil (5-FU) prior to Nedaplatin (NDP) (FN therapy) and that of its reverse sequence (NF therapy) for gynecological malignancy. …”
Publicado 2014
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273por Buhl, Ida Kappel, Gerster, Sarah, Delorenzi, Mauro, Jensen, Thomas, Jensen, Peter Buhl, Bosman, Fred, Tejpar, Sabine, Roth, Arnaud, Brunner, Nils, Hansen, Anker, Knudsen, Steen“…PURPOSE: This study evaluates whether gene signatures for chemosensitivity for irinotecan and 5-fluorouracil (5-FU) derived from in vitro grown cancer cell lines can predict clinical sensitivity to these drugs. …”
Publicado 2016
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274“…OBJECTIVE: We aimed to investigate how the embryonic stem cell-related gene Oct3/4 changes during the injury-repair process of distal pulmonary epithelium induced by 5-fluorouracil (5-Fu). METHODS: We have developed the lung injury model induced by 5-Fu and observed the dynamic changes of Oct3/4 by indirect immunofluorescence, Western blot, and quantitative real-time PCR. …”
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275por Infante, Paola, Faedda, Roberta, Bernardi, Flavia, Bufalieri, Francesca, Lospinoso Severini, Ludovica, Alfonsi, Romina, Mazzà, Daniela, Siler, Mariangela, Coni, Sonia, Po, Agnese, Petroni, Marialaura, Ferretti, Elisabetta, Mori, Mattia, De Smaele, Enrico, Canettieri, Gianluca, Capalbo, Carlo, Maroder, Marella, Screpanti, Isabella, Kool, Marcel, Pfister, Stefan M., Guardavaccaro, Daniele, Gulino, Alberto, Di Marcotullio, Lucia“…Suppressor of Fused (SuFu), a tumour suppressor mutated in medulloblastoma, is a central player of Hh signalling, a pathway crucial for development and deregulated in cancer. …”
Publicado 2018
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276por Tomita, Yoshihiro, Arakawa, Fumiko, Yamamoto, Takafumi, Kuwahara, Motohisa, Watanabe, Ryoji, Iwasaki, Hiroshi, Kikuchi, Masahiro, Kuroki, Masahide“…Mouse monoclonal antibody FU‐MK‐1, raised against a human gastric adenocarcinoma, recognizes an antigen (termed MK‐1 antigen) present on the majority of carcinomas. …”
Publicado 2000
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277por Fu, Yang, Yang, Ge, Xue, Peipei, Guo, Luwei, Yin, Yuhan, Ye, Zhiqiang, Peng, Sanfei, Qin, Yanru, Duan, Qiuhong, Zhu, Feng“…Dasatinib dramatically decreased 5-Fu triggered apoptosis in colon carcinoma via suppression of Src activation. …”
Publicado 2018
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278“…Here, we explored the effect of miR-329 and its target gene on the sensitivity of 5-fluorouracil (5-FU) in the chemotherapy of CRC. RT-qPCR was utilized to determine the expression of miR-329 in cancer tissues, adjacent tissues and cells. …”
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279por Wang, Qiao, Shi, Guoshan, Zhang, Yun, Lu, Feilong, Xie, Duoli, Wen, Chengping, Huang, Lin“…Systemic sclerosis (SSc; scleroderma) is a complicated idiopathic connective tissue disease with seldom effective treatment. GUI-ZHI-FU-LING-WAN (GFW) is a classic Traditional Chinese Medicine (TCM) formula widely used for the treatment of SSc. …”
Publicado 2019
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280“…We found that our FuNP outperformed other software in terms of temporal characteristics and artifacts removal. …”
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