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  1. 41
    “…An increasing number of studies showed that 5-Fu resistance was the main reason for the failure of colorectal cancer treatment. …”
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    Inhibition of CDK1 Reverses the Resistance of 5-Fu in Colorectal Cancer
  2. 42
    “…PURPOSE: The aim was to investigate the pharmacokinetics of preoperatively administered intraperitoneal (IP) 5-FU in patients with resectable pancreatic ductal adenocarcinoma (PDAC) by analyzing levels of 5-FU and target metabolites in peritoneal fluid, plasma, liver, lymph nodes, pancreatic tumour, and pancreatic tissue. …”
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    Pharmacokinetics of preoperative intraperitoneal 5-FU in patients with pancreatic ductal adenocarcinoma
  3. 43
    por Lin, Tz-Feng, Yeh, Shih-Hsuan
    Publicado 2021
    “…The distribution of 5-FU in micelles is related to the PEO and PPO segment length of Pluronic polymers and the environmental temperature. …”
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    Thermosensitive Interfacial Migration of 5-FU in the Microenvironment of Pluronic Block Copolymers
  4. 44
    “…To observe the effects of Fu’s subcutaneous needling (FSN) and acupuncture treatment on the mitochondrial structure and function of the skeletal muscle tissue of rats with sciatica. …”
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    Effects of Fu’s subcutaneous needling on mitochondrial structure and function in rats with sciatica
  5. 45
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    Author Correction: The fusion–fission optimization (FuFiO) algorithm
  6. 46
    “…BACKGROUND: Xuan-Fu-Hua decoction is a traditional Chinese medicine formula widely used for the treatment of inflammation-related disease in the lung and liver. …”
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    Transcriptomic and network pharmacology approaches revealed possible mechanisms underlying the 5-fluorouracil (5-FU)-sensitizing effect of Xuan-Fu-Hua decoction treatment on liver cancer cells
  7. 47
    “…A statistical analysis was performed on the patient data collected from two compassionate-use programmes using oxaliplatin (Eloxatin®) + 5-fluorouracil (5-FU) ± folinic acid (FA), to identify predictive factors for oxaliplatin-based salvage treatment in patients with 5-FU-resistant advanced colorectal cancer (ACRC). 481 5-FU-resistant ACRC patients, most with performance status ≤ 2, ≥ 3 involved sites, and ≥ 2 prior lines of chemotherapy, received oxaliplatin + 5-FU ± FA. …”
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    Factors predicting efficacy of oxaliplatin in combination with 5-fluorouracil (5-FU) ± folinic acid in a compassionate-use cohort of 481 5-FU-resistant advanced colorectal cancer patients
  8. 48
    por Brickell, K, Porter, D, Thompson, P
    Publicado 2003
    “…Interactions between phenytoin and the fluoropyrimidine derivatives, 5 fluorouracil (5FU) and capecitabine, are not commonly documented or widely recognised. …”
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    Phenytoin toxicity due to fluoropyrimidines (5FU/capecitabine): three case reports
  9. 49
    “…Here we reported that a new system, 5-FU-loaded hydrogel system, can improve the therapeutic effects of intraperitoneal chemotherapy. …”
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    5-FU-hydrogel inhibits colorectal peritoneal carcinomatosis and tumor growth in mice
  10. 50
    por Zhang, Qian, Li, Chunsheng
    Publicado 2013
    “…Previous studies have showed that the effects of Shen-Fu injection (SFI) are based on aconitine properties, supplemented by ginsenoside, which can scavenge free radicals, improve energy metabolism, inhibit inflammatory mediators, suppress cell apoptosis, and alleviate mitochondrial damage. …”
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    The Roles of Traditional Chinese Medicine: Shen-Fu Injection on the Postresuscitation Care Bundle
  11. 51
    “…Several modalities of drug administration have been investigated to improve bioavailability and to reduce 5-FU related toxicity. The aim of present study was to evaluate the effect of skimmed milk on the absorption and metabolism of 5-FU in rabbits, mice and dogs. …”
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    Effect of Skimmed Milk on the Absorption and Metabolism of5-Fluorouracil (5-FU) in Animals
  12. 52
    “…Fluorouracil (5-FU) has been wildly used as a primary medication in the treatment of solid tumors including colorectal cancer. …”
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    Determining the optimal 5-FU therapeutic dosage in the treatment of colorectal cancer patients
  13. 53
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    FuSpot: a web-based tool for visual evaluation of fusion candidates
  14. 54
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    Knockout of SIRT4 decreases chemosensitivity to 5-FU in colorectal cancer cells
  15. 55
    “…To investigate the detailed mechanism of 5-FU resistance, we developed a model of 5-FU-resistant cells from HCT-8 cells, a well-established colorectal cancer cell line. …”
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    Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells
  16. 56
    “…The traditional Chinese medicine decoction FuFangChangTai (FFCT) has been used in the therapy of colon cancer clinically, yielding alleviated toxicity and enhanced immunity. …”
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    FuFangChangTai Decoction Activates Macrophages via Inducing Autophagy
  17. 57
    “…BACKGROUND: Septic shock is a serious disease with high morbidity, which will lead to organ dysfunction. Shen fu injection (SFI) has been widely used for septic shock as a treatment in China. …”
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    Shen fu injection for patients with septic shock: Protocol for an updated systematic review
  18. 58
    “…Here, we established 5-Fu resistant CRC cell line (SW620R) and examined the role of YAP in chemotherapy resistance. …”
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    Combinational inhibition of EGFR and YAP reverses 5-Fu resistance in colorectal cancer
  19. 59
    “…5-Fluorouracil (5-FU), a commonly used antimetabolite and antineoplastic agent, has been approved for the treatment of various cancers. …”
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    A unique presentation of 5-fluorouracil (5-FU) induced cerebral encephalopathy
  20. 60
    “…Even if 5‐fluorouracil (5‐FU) is used as the first‐line chemotherapeutic drug, responsiveness is only 20‐30%. …”
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    Overexpression of sortilin is associated with 5‐FU resistance and poor prognosis in colorectal cancer
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