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  1. 3101
    “…RESULTS: Here we present a functional analysis of IN mutants impaired for LEDGF/p75 and TNPO3 interaction. …”
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    Mutations affecting interaction of integrase with TNPO3 do not prevent HIV-1 cDNA nuclear import
  2. 3102
    “…However, the use of such large collections could hamper GBA functional analysis for genes whose expression is condition specific. …”
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    Computational Selection of Transcriptomics Experiments Improves Guilt-by-Association Analyses
  3. 3103
    “…In our previous work, we developed the Functional Analysis through Hidden Markov Models (FATHMM) software and, using a model weighted for inherited disease mutations, observed improved performances over alternative computational prediction algorithms. …”
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    Predicting the functional consequences of cancer-associated amino acid substitutions
  4. 3104
    “…First, in this study, to establish a method for the expression and functional analysis of bovine PD-1, hybridomas producing monoclonal antibodies (mAb) specific for bovine PD-1 were established. …”
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    Blockade of bovine PD-1 increases T cell function and inhibits bovine leukemia virus expression in B cells in vitro
  5. 3105
    “…Global analysis of gene expression profiles and functional analysis of differentially expressed (DE) genes were implemented. …”
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    Gene expression analysis of induced pluripotent stem cells from aneuploid chromosomal syndromes
  6. 3106
    “…By comprehensive functional analysis of the tail during Drosophila oogenesis we have gained an understanding of how KHC achieves specificity in its transport and how it is regulated. …”
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    The auto-inhibitory domain and ATP-independent microtubule-binding region of Kinesin heavy chain are major functional domains for transport in the Drosophila germline
  7. 3107
    “…Protein expression was confirmed by western blotting and functional analysis was carried out using siRNA. RESULTS: Thirteen multiple-drug resistance proteins were identified, as well as seven proteins with specific resistance to cisplatin, including α-enolase. …”
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    Identification of chemoresistant factors by protein expression analysis with iTRAQ for head and neck carcinoma
  8. 3108
    “…Compared with other existing methods in metagenomic functional analysis the new approach is more accurate in assigning reads to functional roles, and therefore at more general levels. …”
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    Statistical Approach of Functional Profiling for a Microbial Community
  9. 3109
    “…The mutation profile is annotated followed by functional analysis through pathway enrichment and network analysis to identify most critical genes and pathways implicated in the disease genesis. …”
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    XomAnnotate: Analysis of Heterogeneous and Complex Exome- A Step towards Translational Medicine
  10. 3110
    “…SMAD3 was identified as a direct target gene of miR-708, and functional analysis demonstrated that miR-708 could markedly suppress osteogenic differentiation and adipogenesis differentiation of MSCs. …”
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    MiR-708 promotes steroid-induced osteonecrosis of femoral head, suppresses osteogenic differentiation by targeting SMAD3
  11. 3111
    “…Ingenuity database was used for functional analysis of DEG. Sixty-sevens DEG (P<0.05) were identified in PBC of patients with DOX-cardiotoxicity. …”
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    Biomarkers for Presymptomatic Doxorubicin-Induced Cardiotoxicity in Breast Cancer Patients
  12. 3112
    “…CONCLUSIONS: RV functional analysis using a RHLA stack resulted in shorter analysis times and lower measurement variability than for a SAX stack orientation.…”
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    Horizontal Long Axis Imaging Plane for Evaluation of Right Ventricular Function on Cardiac Magnetic Resonance Imaging
  13. 3113
    “…Functional analysis using NOG annotation showed that 82.79% of proteins are poorly characterized indicating the possibility of novel microbial functions and with potential biomedical and biotechnological applications. …”
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    Unraveling the microbial and functional diversity of Coamo thermal spring in Puerto Rico using metagenomic library generation and shotgun sequencing
  14. 3114
    “…CONCLUSION: These encouraging results provide new therapeutical opportunities in pancreatic cancer treatment and build the basis for further functional analysis as well as first clinical studies for this promising agent.…”
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    Innovative substance 2250 as a highly promising anti-neoplastic agent in malignant pancreatic carcinoma - in vitro and in vivo
  15. 3115
    “…The potential target genes of differentially expressed (DE) co-miRNAs were predicted in the methamphetamine and ketamine rats, then functional analysis of their target genes was performed. …”
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    Expression of microRNAs in the serum exosomes of methamphetamine-dependent rats vs. ketamine-dependent rats
  16. 3116
    por Zhou, Lu, Wang, Jiaqi, Wang, Tailing
    Publicado 2018
    “…The coding region of the FOXL2 gene was amplified and mutations were determined by sequencing analyses. Functional analysis was carried out to study changes in expression and transcriptional activity of the mutant FOXL2 protein. …”
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    Functional study on new FOXL2 mutations found in Chinese patients with blepharophimosis, ptosis, epicanthus inversus syndrome
  17. 3117
    “…Here we will focus on the functional analysis of missense mutations found in SHANK genes. …”
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    Functional Relevance of Missense Mutations Affecting the N-Terminal Part of Shank3 Found in Autistic Patients
  18. 3118
    “…FINDINGS: The level of DENV2 replication was correlated with the magnitude of the plasmablast response. Functional analysis of plasmablast-derived monoclonal antibodies showed that the DENV2-specific response was dominated by cells producing DENV2 serotype-specific antibodies. …”
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    Longitudinal analysis of acute and convalescent B cell responses in a human primary dengue serotype 2 infection model
  19. 3119
    “…Proteomic analysis and subsequent biological functional analysis identified eight proteins that were up/downregulated by ricin treatment and which might thus contribute to ricin toxicity. …”
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    Effects of ricin on primary pulmonary alveolar macrophages
  20. 3120
    “…Here we demonstrate how MPs (native and batch synthesized) from ER derived microsomes can be processed for functional analysis by electrophysiology and radioactive uptake assay methods. …”
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    Functional Reconstitution of Membrane Proteins Derived From Eukaryotic Cell-Free Systems
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