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  1. 3301
    “…MiRWalk 2.0 tool was used to predict miRNA-mRNA pairs. Subsequently, functional analysis and immune cell infiltration analysis were performed to explore the pivotal functions of the target genes. …”
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    Uncovering key molecules and immune landscape in cholestatic liver injury: implications for pathogenesis and drug therapy
  2. 3302
    “…At the same time, the functional analysis of these identified venom proteins was carried out separately. …”
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    Comparative Analysis of the Venom Proteins from Two Eupelmid Egg Parasitoids Anastatus japonicus and Mesocomys trabalae
  3. 3303
    “…Nerve regeneration was assessed by functional analysis using the Visual Statisc Sciatic Index (SSI) and MR neurography during the 12-week regeneration period. …”
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    Avoiding scar tissue formation of peripheral nerves with the help of an acellular collagen matrix
  4. 3304
    “…Among them, 527 proteins were quantified using peak intensity-based semi-quantification (iBAQ), covering a wide dynamic range of approximately 8 orders of magnitude. Based on the functional analysis, we proposed a hypothetical mechanism of OME. …”
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    Proteomic Study of Middle Ear Effusion and Its Clinical Application for Otitis Media with Effusion
  5. 3305
    “…Functional enrichment analysis of differentially methylated mRNAs screened between the two groups after sequencing showed that they mainly regulated cell development, spermatogenesis, and testicular endocrine function. Functional analysis of the differentially expressed genes screened between the two groups showed that they were involved in the biological processes of mitosis, meiosis, and flagellated sperm motility. …”
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    Transcriptome Studies Reveal the N(6)-Methyladenosine Differences in Testis of Yaks at Juvenile and Sexual Maturity Stages
  6. 3306
    por Steel, G, Lutz, E M
    Publicado 2007
    “…Here, we report the characterisation of the gene that encodes the mouse VPAC(2) receptor (Vipr2), localisation of the transcriptional start site and functional analysis of the promoter region. The Vipr2 gene contains 12 introns within its protein-coding region and spans 68.6 kb. …”
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    Characterisation of the Mouse Vasoactive Intestinal Peptide Receptor Type 2 Gene, Vipr2, and Identification of a Polymorphic LINE-1-like Sequence That Confers Altered Promoter Activity
  7. 3307
    “…CONCLUSION: A new tetraspanin family (Tsp3) and a tetraspanin-like protein family (Tpl1) have been identified in fungi. Functional analysis by gene replacement showed that these proteins, as well as Pls1, are involved in the infection process of the plant pathogenic fungus M. grisea. …”
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    Fungi have three tetraspanin families with distinct functions
  8. 3308
    “…Mutations T404fsX30 and R355fsX69 were the most prevalent among index cases and were detected in six (23.0%) and three (11.5%) patients, respectively. Functional analysis showed that the three nonsense mutants assayed (E173X, E262X, and W341X) and F261L were null alleles. …”
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    CYP1B1 mutations in Spanish patients with primary congenital glaucoma: phenotypic and functional variability
  9. 3309
    “…The rank order of inhibitor potency was OLT ≫ TBD ≫ D3T, with IC(50) values estimated as 0.2, 12.8 and >100 μM, respectively. Functional analysis revealed that OLT and TBD, in addition to their effects on CYP, modulate liver lipid metabolism, especially fatty acids. …”
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    Chemical genomics of cancer chemopreventive dithiolethiones
  10. 3310
    “…BACKGROUND: The purpose of this study was to identify new tumour suppressor microRNAs (miRs) in clear cell renal cell carcinoma (ccRCC), carry out functional analysis of their suppressive role and identify their specific target genes. …”
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    Tumour suppressor microRNA-584 directly targets oncogene Rock-1 and decreases invasion ability in human clear cell renal cell carcinoma
  11. 3311
    “…The network topological features indicated that MDD is similar to schizophrenia compared to cancer. In the functional analysis, we performed the gene set enrichment analysis for both Gene Ontology categories and canonical pathways. …”
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    A comprehensive network and pathway analysis of candidate genes in major depressive disorder
  12. 3312
    “…Furthermore, we performed functional analysis to identify a group of dysregulated miRNAs that could be responsible for the selective suppression of low molecular weight neurofilament (NFL) mRNA observed in ALS. …”
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    Altered microRNA expression profile in amyotrophic lateral sclerosis: a role in the regulation of NFL mRNA levels
  13. 3313
    “…The expression of Sox9 was likewise negatively regulated by miR-101 in rat chondrocytes. Functional analysis showed that miR-101 could aggravate chondrocyte ECM degradation, whereas miR-101 inhibition could reverse IL-1β-induced ECM degradation. …”
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    Silencing of microRNA-101 prevents IL-1β-induced extracellular matrix degradation in chondrocytes
  14. 3314
    “…Several annotation pipelines have been developed for functional analysis based on sequence, ‘omics’, and literature data. …”
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    Evaluation and integration of functional annotation pipelines for newly sequenced organisms: the potato genome as a test case
  15. 3315
    “…The transmembrane glucose transporter gene AGAP007752 was selected for functional analysis by RNA interference. The effect of gene silencing on infection level was evaluated. …”
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    Gene expression changes in the salivary glands of Anopheles coluzzii elicited by Plasmodium berghei infection
  16. 3316
    “…We performed a functional analysis of rs10019009 via reverse transcription-polymerase chain reaction, alkaline phosphatase (ALP) activity in human osteosarcoma U(2)OS cells. …”
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    Association Between Dentin Matrix Protein 1 (rs10019009) Polymorphism and Ankylosing Spondylitis in a Chinese Han Population from Shandong Province
  17. 3317
    “…The transcriptional profile of the SH-SY5Y human neuroblastoma cell line overexpressing ROP16 were determined by microarray analysis in order to determine the host neural cell response to the virulent factor. Functional analysis was performed using the Protein Analysis Through Evolutionary Relationships classification system. …”
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    Transcriptional profile of SH-SY5Y human neuroblastoma cells transfected by Toxoplasma rhoptry protein 16
  18. 3318
    “…Differentially-expressed genes (DEGs) were identified from CRC samples compared with adjacent non-cancerous controls using the Limma package in R, followed by functional analysis using the Database for Annotation, Visualization, and Integrated Discovery online tool. …”
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    Microarray analysis of differentially-expressed genes and linker genes associated with the molecular mechanism of colorectal cancer
  19. 3319
    “…To the best of our knowledge, this is the first report on the functional analysis of unknown membrane proteins belonging to DUF1538 family.…”
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    Characterization of a novel two-component Na(+)(Li(+), K(+))/H(+) antiporter from Halomonas zhaodongensis
  20. 3320
    “…We then predicted the potential target genes of selected, differentially expressed (DE) miRNAs and then carried out functional analysis of these target genes. We also verified our results by RT-qPCR. …”
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    Expression of miRNAs in Serum Exosomes versus Hippocampus in Methamphetamine-Induced Rats and Intervention of Rhynchophylline
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