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  1. 3401
    “…We next performed functional analysis to determine DEARGs’ possible roles. …”
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    Identifying Aging-Related Biomarkers and Immune Infiltration Features in Diabetic Nephropathy Using Integrative Bioinformatics Approaches and Machine-Learning Strategies
  2. 3402
    “…METHODS: For gene expression analysis, 9 tumours (TUM) and their paired normal mucosa (NM) were hybridized on 4 × 44K Whole rat arrays (Agilent) and selected genes were validated by semi-quantitative RT-PCR. Functional analysis on microarray data was performed by GenMAPP/MappFinder analysis. …”
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    Gene expression profile and genomic alterations in colonic tumours induced by 1,2-dimethylhydrazine (DMH) in rats
  3. 3403
    “…The tTA cDNA was inserted into a 196 kb PAC containing a genomic mouse Tph2 fragment (177 kb) by homologous recombination in E. coli. For functional analysis of Ptet-controlled transgene expression, TPH2-tTA mice were crossed to a Ptet-regulated lacZ reporter line (Ptet-nLacZ). …”
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    Tetracycline Inducible Gene Manipulation in Serotonergic Neurons
  4. 3404
    “…The most significant outcome of the present work is that it lays out a roadmap for future studies of regulatory mechanisms by providing a list of key candidate genes for functional analysis.…”
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    Transcriptomic changes during regeneration of the central nervous system in an echinoderm
  5. 3405
    “…Based on their distinct profiles, miRNAs from sera and exosomes may reflect different aspects of physiological and pathological conditions in cattle. The functional analysis suggest that sera may be preferable for the purpose of detecting inflammation in cattle, while exosomes may be a better choice for monitoring the status of muscle development and lipid metabolism. …”
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    Comparative miRNAome analysis revealed different miRNA expression profiles in bovine sera and exosomes
  6. 3406
    “…We assembled a high likelihood dataset which we used to perform co-expression and functional analysis of the most stably iron deficiency-induced genes. …”
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    Iron homeostasis in Arabidopsis thaliana: transcriptomic analyses reveal novel FIT-regulated genes, iron deficiency marker genes and functional gene networks
  7. 3407
    “…CONCLUSIONS: The results showed that most of the SDs were “unique SDs”, which originated after species formation. Functional analysis suggested that SDs might play different roles in different species. …”
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    Segmental duplications: evolution and impact among the current Lepidoptera genomes
  8. 3408
    “…Gene structural and functional analysis, target prediction, annotation clustering, and pathway enrichment analysis were executed. …”
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    Structure and functional impact of seed region variant in MIR-499 gene family in bronchial asthma
  9. 3409
    “…No reference genome to facilitate functional analysis is available for this species. RESULTS: To better understand the virulence factor at both phenotypic and genomic level, we characterized 15 H. parviporum isolates originating from different locations across Finland for virulence, vegetative growth, sporulation and saprotrophic wood decay. …”
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    Intraspecific comparative genomics of isolates of the Norway spruce pathogen (Heterobasidion parviporum) and identification of its potential virulence factors
  10. 3410
    “…The relevance of the genetic signature for the model is inspected by a functional analysis. RESULTS: BLASSO has been compared with a baseline LASSO model. …”
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    BLASSO: integration of biological knowledge into a regularized linear model
  11. 3411
    “…Background: The objectives of any metagenomic study typically include identification of resident microbes and their relative proportions (taxonomic analysis), profiling functional diversity (functional analysis), and comparing the identified microbes and functions with available metadata (comparative metagenomics). …”
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    iVikodak—A Platform and Standard Workflow for Inferring, Analyzing, Comparing, and Visualizing the Functional Potential of Microbial Communities
  12. 3412
    “…Based on the ceRNA hypothesis and considering the synergistic or feedback regulation of ceRNAs, a lncRNA–miRNA–mRNA network was constructed. Functional analysis was performed using gene ontology term and KEGG pathway enrichment analysis and KOBAS 2.0 software. …”
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    Integrated analysis reveals five potential ceRNA biomarkers in human lung adenocarcinoma
  13. 3413
    “…Expression levels, transcript biotypes, alternative splicing and other features of the regulated transcripts were studied. A functional analysis was performed to determine overrepresented ontological groups among gene expression profiles. …”
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    Systemic response to rupture of intracranial aneurysms involves expression of specific gene isoforms
  14. 3414
    “…We identified 116 DEGs including 81 upregulated and 35 downregulated DEGs. Functional analysis revealed that they were significantly enriched in the extracellular region and biosynthesis of amino acids. …”
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    Identification of Potential Biomarkers in Association With Progression and Prognosis in Epithelial Ovarian Cancer by Integrated Bioinformatics Analysis
  15. 3415
    “…Single marker association analyses revealed four most significant single nucleotide polymorphisms (SNPs) mainly affecting milk protein percentage or milk fat yield in buffalo. Genes functional analysis indicated that these DGAT family genes could influence lactation performance in the mammal through regulating lipid metabolism. …”
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    Genome-wide identification of Diacylglycerol Acyltransferases (DGAT) family genes influencing Milk production in Buffalo
  16. 3416
    “…Most importantly, proteins can be processed for downstream applications like purification and functional analysis without the necessity of transfection, selection, and expansion of clones. …”
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    Cell-Free Protein Synthesis: A Promising Option for Future Drug Development
  17. 3417
    “…A ceRNA network was constructed among 81 lncRNAs, 9 miRNAs, and 197 mRNAs. Functional analysis showed that numerous mRNAs were significantly associated with regulation of cellular glucuronidation. …”
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    Identification of RNA Transcript Makers Associated With Prognosis of Kidney Renal Clear Cell Carcinoma by a Competing Endogenous RNA Network Analysis
  18. 3418
    “…MF did not activate glucocorticoid or androgen receptors in LCTs. Functional analysis showed that PGRMC1 is required for MF and P4 to stimulate the proliferation and invasiveness of LCTs. …”
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    Mifepristone Treatment Promotes Testicular Leydig Cell Tumor Progression in Transgenic Mice
  19. 3419
    “…The C-index of the nomogram achieved 0.74 (0.69–0.80) in the primary cohort and 0.82 (0.77–0.87) in the validation cohort. Functional analysis and correlation analysis found that the radiomic signatures were mainly associated with metabolism related pathways. …”
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    A Metabolism-Related Radiomics Signature for Predicting the Prognosis of Colorectal Cancer
  20. 3420
    “…The PINK1 p.R501Q functional analysis revealed pathogenic loss of function. …”
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    Early-Onset Parkinson Disease Screening in Patients From Nigeria
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