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  1. 3821
    “…Furthermore, the expression level of most such transporters in plants is likely to be too low for purification and downstream functional analysis. Heterologous expression systems should address both of these issues. …”
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    Heterologous Expression of a Membrane-Spanning Auxin Importer: Implications for Functional Analyses of Auxin Transporters
  2. 3822
    “…The T-512C polymorphism located in the 5′ untranslated region was associated with a decreased risk of recurrent cardiovascular events during follow-up. The functional analysis of the R38C polymorphism showed that it leads to a profound change in expression and activity of hGX sPLA2, although there was no detectable impact on CAD risk. …”
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    Molecular and functional characterization of polymorphisms in the secreted phospholipase A2 group X gene: relevance to coronary artery disease
  3. 3823
    “…However, its small size makes surgical treatment and electrophysiological manipulation technically difficult, hampering the functional analysis of neuronal circuits that play critical roles in memory processing. …”
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    Neuronal Mechanisms of Learning and Memory Revealed by Spatial and Temporal Suppression of Neurotransmission Using Shibire(ts1), a Temperature-Sensitive Dynamin Mutant Gene in Drosophila Melanogaster
  4. 3824
    por Ichida, Kimiyoshi
    Publicado 2009
    “…Recent genome-wide association studies have led to validation of the in vitro model constructed from each functional analysis of urate transporters, and identification of novel candidate genes related to urate metabolism and transport proteins, such as glucokinase regulatory protein (GKRP), PDZK1 and MCT9. …”
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    What lies behind serum urate concentration? Insights from genetic and genomic studies
  5. 3825
    “…We identified in silico their predicted targets, several of which match the genes that have been identified to be differentially expressed in ectopic versus eutopic endometrium in studies of gene expression. A functional analysis of the predicted targets indicates that several of these are involved in molecular pathways implicated in endometriosis, thus strengthening the hypothesis of the role of microRNAs in this pathology.…”
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    Differential Expression of MicroRNAs between Eutopic and Ectopic Endometrium in Ovarian Endometriosis
  6. 3826
    “…We also reviewed how these tools were used to generate a large collection of mutants and how these mutants can be screened and detected for functional analysis of a gene. The data suggested that the current population of mutants might be large enough to tag all predicted genes. …”
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    Natural and artificial mutants as valuable resources for functional genomics and molecular breeding
  7. 3827
    “…Structural modeling and functional analysis of the intermediates of transcription through a nucleosome was conducted. …”
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    Mechanism of chromatin remodeling and recovery during passage of RNA polymerase II
  8. 3828
    “…Recently raloxifene response element (RRE), a new enhancer with a polypurine sequence for estrogen receptor (ER)-mediated gene activation, was identified on the TGF-beta 3 gene. Functional analysis of the RRE-mediated pathway has shown that this would be an important pathway for bone preserving effect. …”
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    Identification of a mutation in the human raloxifene response element of the transforming growth factor-beta 3 gene.
  9. 3829
    “…Two large-scale studies are then described: (i) the mapping and visualization of the barcodes on the human chromosomes and (ii) automatic clustering of the barcodes to highlight protein subsets sharing similar evolutionary histories and their functional analysis. The methodologies developed here open the way to the efficient application of other data mining and knowledge extraction techniques in evolutionary systems biology studies. …”
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    EvoluCode: Evolutionary Barcodes as a Unifying Framework for Multilevel Evolutionary Data
  10. 3830
    por Chen, Shengyong, Li, Xiaoli
    Publicado 2012
    “…This paper introduces the fundamental principles and summarizes the research progress of the last year for imaging neural activity in the human brain. Aims of functional analysis of neural activity from fMRI include biological findings, functional connectivity, vision and hearing research, emotional research, neurosurgical planning, pain management, and many others. …”
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    Functional Magnetic Resonance Imaging for Imaging Neural Activity in the Human Brain: The Annual Progress
  11. 3831
    por Veltz, Romain, Faugeras, Olivier
    Publicado 2011
    “…The first method involves tools of functional analysis and yields a new estimate of the semigroup of the previous linear operator using the eigenvalues of its infinitesimal generator. …”
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    Stability of the stationary solutions of neural field equations with propagation delays
  12. 3832
    “…Using methods from the theory of functional analysis we show the existence and uniqueness of a solution of these equations. …”
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    Analysis of a hyperbolic geometric model for visual texture perception
  13. 3833
    “…Nonetheless, transformation protocols have remained a significant bottleneck for this pathogen, hindering functional analysis research in many labs. RESULTS: In this study, we tested three different transformation methods for B. cinerea: electroporation, air-pressure-mediated and sclerotium-mediated transformation. …”
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    Transformation of Botrytis cinerea by direct hyphal blasting or by wound-mediated transformation of sclerotia
  14. 3834
    “…The relevance of DNBs with the diseases was also validated by related experimental data and functional analysis.…”
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    Detecting early-warning signals for sudden deterioration of complex diseases by dynamical network biomarkers
  15. 3835
    por Jakobi, Arjen J., Huizinga, Eric G.
    Publicado 2012
    “…Although we primarily designed this strategy to accelerate assembly of repetitive constructs for single-molecule force spectroscopy, we anticipate that this approach is equally applicable to the reconstitution and modification of complex modular sequences including structural and functional analysis of multi-domain proteins, synthetic biology or the modular construction of episomal vectors.…”
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    A Rapid Cloning Method Employing Orthogonal End Protection
  16. 3836
    por Cao, Jun, Shi, Feng
    Publicado 2012
    “…Our findings shed light on several key differences in RALF gene family evolution among the plant species, which may provide a scaffold for future functional analysis of this family.…”
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    Evolution of the RALF Gene Family in Plants: Gene Duplication and Selection Patterns
  17. 3837
    “…This model will be used in wide range of studies for functional analysis and improvement activity of the protein.…”
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    Homology Modeling and Functional Characterization of PR-1a Protein of Hordeum vulgare subsp. Vulgare
  18. 3838
    “…The effectiveness of this method was validated by functional analysis and experimental data.…”
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    Identifying critical transitions and their leading biomolecular networks in complex diseases
  19. 3839
    por Chan, Zhulong
    Publicado 2013
    “…Comparative proteome profiling and functional analysis revealed that defense related proteins, energy metabolism, and antioxidant pathway played important roles in fruits in response to storage conditions and exogenous elicitor treatments. …”
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    Proteomic responses of fruits to environmental stresses
  20. 3840
    “…Sequence conservation of the distal CTD identifies putative membrane and protein interaction sites, the latter of which bind the N-terminal helix of Gα(q) in both the crystal structure and cryo-EM reconstructions. Functional analysis suggests the distal CTD plays roles in membrane targeting and in optimizing the orientation of the catalytic core at the membrane for maximal rates of lipid hydrolysis.…”
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    Full-Length Gα(q)–Phospholipase C-β3 Structure Reveals Interfaces of the C-terminal Coiled-Coil Domain
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