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  1. 3901
    por Roland, Damian
    Publicado 2018
    “…One approach is to utilise the Functional Analysis Resonance Method (FRAM), which enables systems to examine process and sociocontextual issues in treatment and management pathways. …”
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    Guideline developers are not the only experts: Utilising the FRAM method in sepsis pathways
  2. 3902
    “…More specifically, we carried out an interview-based structural-functional analysis to identify underlying systemic problems, reveal their patterns of interaction, and analyse the implications of these patterns for the relationship among the key processes within the innovation system, the so-called system functions. …”
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    Interaction patterns of systemic problems in distributed energy technology diffusion: a case study of photovoltaics in the Western Cape province of South Africa
  3. 3903
    “…Herein, we have tested several combinations of published protocols, for example, growth factor vs. small molecule and different time durations of treatment for definitive endoderm (DE) induction and further hepatocyte differentiation to develop an efficient DE induction and hepatocyte differentiation in a highly reproducible manner based on the stage-specific marker expression and functional analysis.…”
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    Fine Tuning of Hepatocyte Differentiation from Human Embryonic Stem Cells: Growth Factor vs. Small Molecule-Based Approaches
  4. 3904
    por Sun, Yuyan, Fan, Min, He, Yanjun
    Publicado 2019
    “…A total of 1641 differently expressed genes (DEGs) were identified, with 886 DEGs upregulated and 755 DEGs downregulated after CGMMV infection. A functional analysis indicated that the DEGs were involved in photosynthesis, plant–pathogen interactions, secondary metabolism, and plant hormone signal transduction. …”
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    Transcriptome Analysis of Watermelon Leaves Reveals Candidate Genes Responsive to Cucumber green mottle mosaic virus Infection
  5. 3905
    “…Artificial melanin synthesized using conventional methods is insoluble, making structural and functional analysis of this chemical difficult. In this study, we describe a melanin solubilization method based on polymerization of homogentisic acid (solubilizing component) and an equivalent amount of L‐DOPA in the presence of laccase. …”
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    Solubilized melanin suppresses macrophage function
  6. 3906
    “…We describe our approach for setting up and executing the functional analysis of META-pipe on additional academic and commercial clouds. …”
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    META-pipe cloud setup and execution
  7. 3907
    “…The combined effects of these truncated forms augmented doxorubicin-induced cytotoxicity. Functional analysis demonstrated that these fragments and their combination with doxorubicin can arrest cells in the G2 phase of the cell cycle as specified by flow cytometry. …”
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    N-Terminal Domain of Fragile Histidine Triad Exerts Potent Cytotoxic Effect in HT1080 Cells and Increases Doxorubicin Cytotoxicity
  8. 3908
    por Grinter, Rhys, Lithgow, Trevor
    Publicado 2019
    “…The structural data, in combination with functional analysis, presented in this work show that FhuE has evolved to specifically engage with planar siderophores. …”
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    Determination of the molecular basis for coprogen import by Gram-negative bacteria
  9. 3909
    “…The characterization of plant m6A writers, erasers and readers, as well as the elucidation of their functions, is currently one of the most fascinating hotspots in plant biology research. The functional analysis of m6A in plants will be booming in the foreseeable future, which could contribute to crop genetic improvement through epitranscriptome manipulation. …”
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    N6‐methyladenosine regulatory machinery in plants: composition, function and evolution
  10. 3910
    “…Here, we have used functional analysis of mutant transporters combined with molecular dynamics simulations of lipid-transporter interactions to understand how these bioactive lipids interact with GlyT2. …”
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    Identification of an allosteric binding site on the human glycine transporter, GlyT2, for bioactive lipid analgesics
  11. 3911
    “…We performed structural and functional analysis of these proteins and validated our findings with a combination of RIP-qPCR experiments, in vitro results released in past studies, publicly available RIP- and eCLIP-seq data, and results from software tools for predicting RNA–protein interactions.…”
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    Comprehensive in vivo identification of the c-Myc mRNA protein interactome using HyPR-MS
  12. 3912
    “…Here, we have combined proteomics, gene expression profiling, functional analysis, and metabolic tracing to decipher the impact of MYCN on neuroblastoma cell metabolism. …”
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    MYCN-enhanced Oxidative and Glycolytic Metabolism Reveals Vulnerabilities for Targeting Neuroblastoma
  13. 3913
    “…Fusion of GFP and phase-contrast images is of high significance to the study of subcellular localization, protein functional analysis, and genetic expression. This paper proposes a novel algorithm to fuse these two types of biological images via generative adversarial networks (GANs) by carefully taking their own characteristics into account. …”
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    Green Fluorescent Protein and Phase-Contrast Image Fusion via Generative Adversarial Networks
  14. 3914
    “…The results in Drosophila wing discs indicate that silence of Usp10 decreases the transcription of target genes of the Hippo pathway by reducing Yki protein. In vivo functional analysis ulteriorly showed that Usp10 upregulates the Yki activity in Drosophila eyes. …”
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    Usp10 Modulates the Hippo Pathway by Deubiquitinating and Stabilizing the Transcriptional Coactivator Yorkie
  15. 3915
    “…Several hundreds of genes were differentially expressed after grape intake or after washout. The functional analysis of these genes detected significant changes in key processes such as inflammation and immunity, thrombosis, DNA and protein repair, autophagy and mitochondrial biogenesis. …”
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    Microarray data and pathway analyses of peripheral blood mononuclear cells from healthy subjects after a three weeks grape-rich diet
  16. 3916
    por Wang, Xiao, Li, Tianzuo
    Publicado 2020
    “…The survival analyses were investigated. The functional analysis of the prognostic signature was examined. …”
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    Development of a 15-gene signature for predicting prognosis in advanced colorectal cancer
  17. 3917
    “…Thus, FV-LVs provide an efficient method for functional analysis of genes involved in SSCs and spermatogenesis.…”
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    Transgenesis and Genome Editing of Mouse Spermatogonial Stem Cells by Lentivirus Pseudotyped with Sendai Virus F Protein
  18. 3918
    “…In this review, we summarize the work conducted in rice, maize, and barley for the genetic dissection of the pathway and the functional analysis of the genes involved. Similarities and differences detected in these species for the BR role in plant development are presented. …”
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    The Role of Brassinosteroids in Controlling Plant Height in Poaceae: A Genetic Perspective
  19. 3919
    “…Moreover, there was slight coverage between DEG and DAS genes. Furthermore, functional analysis showed that the DAS genes are most frequently related to ion binding and stimulus response. …”
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    Integrative analysis of gene expression and alternative splicing in microalgae grown under heterotrophic condition
  20. 3920
    “…This study aims at verifying the hypothesis by applying mining to these two datasets to elucidate the contrast in the influence of the design variables. We used functional analysis of variance for data mining; scrutinized the effects of single and two-combined design variables. …”
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    Hypothesis Verification for Designing Flyback Booster by Analysis of Variance Visualized on Triangular Matrix Representations
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