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  1. 4101
    “…The candidate effectors and putative pathogenicity determinants identified in this study will help in the functional analysis of C. pseudoreteaudii virulence and pathogenicity.…”
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    Transcriptomic Analysis of Calonectria pseudoreteaudii during Various Stages of Eucalyptus Infection
  2. 4102
    “…Here we report functional analysis of a gap junction protein, Innexin 2 (Inx2), in cell type specification during Drosophila oogenesis. …”
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    A Gap Junction Protein, Inx2, Modulates Calcium Flux to Specify Border Cell Fate during Drosophila oogenesis
  3. 4103
    “…Transcription factors are master regulators of gene expression at the transcriptional level, and controlling the activity of these factors alters the transcriptome of the plant, leading to metabolic and phenotypic changes in response to stress. The functional analysis of interactions between transcription factors and other proteins is very important for elucidating the role of these transcriptional regulators in different signaling cascades. …”
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    Transcription Factor Functional Protein-Protein Interactions in Plant Defense Responses
  4. 4104
    “…With the rapid accumulation of gene expression data, gene functional module identification has become a widely used approach in functional analysis. However, tools to identify organelle functional modules and analyze their relationships are still missing. …”
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    Constructing Networks of Organelle Functional Modules in Arabidopsis
  5. 4105
    “…Our detailed description of all glial subtypes and their regional specializations, together with the powerful genetic toolkit we provide, will facilitate the functional analysis of glia in the mature nervous system. …”
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    The glia of the adult Drosophila nervous system
  6. 4106
    “…Interestingly, expression levels of identified TFs did not always change and indicate additional post-transcriptional regulatory mechanisms. Functional analysis revealed that forced expression of IRF2 enhances osteogenic differentiation. …”
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    Identification of Three Early Phases of Cell-Fate Determination during Osteogenic and Adipogenic Differentiation by Transcription Factor Dynamics
  7. 4107
    “…These responses might help HUVECs and their MVs deal with the more oxidising conditions found in older cells. Functional analysis confirmed the antioxidant machinery of the MVs to be active and to increase in size with senescence. …”
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    The Antioxidant Machinery of Young and Senescent Human Umbilical Vein Endothelial Cells and Their Microvesicles
  8. 4108
    “…In this paper, we carry on the functional analysis of still not well-known centrins, the ICL1e subfamily identified in Paramecium, and show their requirement for correct basal body anchoring through interactions with Centrin2 and Centrin3. …”
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    Centrin diversity and basal body patterning across evolution: new insights from Paramecium
  9. 4109
    “…Among the 66 significantly differentially expressed proteins in Fg1, 39 and 27 were more or less abundant expressed. Functional analysis suggested that the enzymes involved in the methylerythritol 4-phosphate and mevalonate pathways, which provide a substrate for biosynthesis of farnesyl pyrophosphate, a precursor of DON, were activated in Fg1. …”
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    Screening of Deoxynivalenol Producing Strains and Elucidation of Possible Toxigenic Molecular Mechanism
  10. 4110
    “…This study aimed to fill in the knowledge gap and examined their influence on the performances of logistic regression (LR) approaches in DIF detections, including the ordinal logistic regression (OLR) and the logistic discriminant functional analysis (LDFA). Results indicated that both the standard OLR and LDFA yielded severely inflated false positive rates as the magnitude of the differences in ERS increased between two groups. …”
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    Modified Logistic Regression Approaches to Eliminating the Impact of Response Styles on DIF Detection in Likert-Type Scales
  11. 4111
    “…Here, we show that the Na(+)/Ca(2+), K(+) exchanger NCKX4 is expressed in zebrafish, mouse, and primate cones. Functional analysis of NCKX4-deficient mouse cones revealed that this exchanger is essential for the wide operating range and high temporal resolution of cone-mediated vision. …”
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    The Na(+)/Ca(2+), K(+) exchanger NCKX4 is required for efficient cone-mediated vision
  12. 4112
    “…We undertook a transcriptome and functional analysis of human induced pluripotent stem cell (iPSC)-derived BMECs (iBMEC) from HD patients or unaffected controls. …”
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    Huntington’s Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits
  13. 4113
    “…The significance of expression of the hub genes in ccRCC was ranked top 4 among all cancers and correlated with poor prognosis. Functional analysis revealed that the hub genes were significantly enriched in cell cycle regulation and cell division. …”
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    Co-expression network analysis identified six hub genes in association with progression and prognosis in human clear cell renal cell carcinoma (ccRCC)
  14. 4114
    “…This network contained 351 nodes including 98 mRNAs, 86 microRNAs and 167 lncRNAs. Functional analysis showed that the mRNAs in DMCN were annotated into some diabetes‐related pathways. …”
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    Construction of competitive endogenous RNA network reveals regulatory role of long non‐coding RNAs in type 2 diabetes mellitus
  15. 4115
    “…To detect the differentiation stages of the MSCs, immunostaining of hepatocyte markers and functional analysis was performed. Compared with traditional 2D monolayer induction, mouse BM-MSCs spheroids and DLSs in 3D culture generated greater yields of mature, differentiated hepatocytes. …”
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    Hepatic differentiation of mouse bone marrow-derived mesenchymal stem cells using a novel 3D culture system
  16. 4116
    “…Interestingly, most “ground-state miRNAs” are encoded by an imprinted region on chromosome 12 within the Dlk1-Dio3 locus. Functional analysis revealed that ground-state miRNAs embedded in the Dlk1-Dio3 locus (miR-541-5p, miR-410-3p, and miR-381-3p) promoted pluripotency via inhibition of multi-lineage differentiation and stimulation of self-renewal. …”
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    Small RNA Sequencing Reveals Dlk1-Dio3 Locus-Embedded MicroRNAs as Major Drivers of Ground-State Pluripotency
  17. 4117
    “…The CPPs form strongly interconnected networks and are annotated to a variety of biological functions, including RNA splicing, protein translation, and chromatin remodeling. Functional analysis of select CPPs revealed the requirement for eukaryotic initiation factor three subunit A (eIF3A), fused in sarcoma (FUS), and ribosomal protein s17 (RPS17) in experience-dependent structural plasticity in tectal neurons and behavioral plasticity in tadpoles. …”
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    Role of the visual experience-dependent nascent proteome in neuronal plasticity
  18. 4118
    “…In doing so, we have identified 167 gene families that govern phage resistance in our strain set and performed functional analysis on them. This revealed genes of possible prophage or mobile genetic element origin, along with genes involved in restriction-modification and transcription regulators, though the majority were genes of unknown function. …”
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    Use of a Regression Model to Study Host-Genomic Determinants of Phage Susceptibility in MRSA
  19. 4119
    “…Here, we report a novel protein elicitor BAR11 from the biocontrol strain Hhs.015 and its functions in plant defense responses. Functional analysis showed that the elicitor BAR11 significantly stimulated plant systemic resistance in Arabidopsis thaliana to Pseudomonas syringae pv. tomato DC3000. …”
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    A Novel Protein Elicitor BAR11 From Saccharothrix yanglingensis Hhs.015 Improves Plant Resistance to Pathogens and Interacts With Catalases as Targets
  20. 4120
    “…Network motifs are significantly overrepresented subgraphs that have been proposed as building blocks for natural and engineered networks. Detailed functional analysis has been performed for many types of motif in isolation, but less is known about how motifs work together to perform complex tasks. …”
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    Organization of feed-forward loop motifs reveals architectural principles in natural and engineered networks
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