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  1. 4121
    “…We determined the status of p53 by functional analysis of separated alleles in yeast in five human colon cancer cell lines, SW‐480, SW‐620, DLD‐1, COLO320 and LS174T and investigated whether p53 is necessary for apoptosis and cell cycle arrest after treatment of the cells with a DNA‐damaging agent, etoposide (VP‐16), or γ‐irradiation. …”
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    Induction of p53‐independent Apoptosis Associated with G2M Arrest Following DNA Damage in Human Colon Cancer Cell Lines
  2. 4122
    “…Target prediction and functional analysis of color-related miRNAs showed that a variety of putative target genes—including slc7a11, mc1r and asip—played potential roles in pigmentation. …”
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    Comparative microRNA-seq Analysis Depicts Candidate miRNAs Involved in Skin Color Differentiation in Red Tilapia
  3. 4123
    por Singh, Pranveer
    Publicado 2018
    “…Efficiency of refolding protocol was validated by structural analysis by CD, native folding by fluorescence and functional analysis by its binding with full length HIV-1 gp120 via SPR. …”
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    Surface plasmon resonance (SPR) based binding studies of refolded single chain antibody fragments
  4. 4124
    “…The resistant cell line showed increased expression of MDR1 transcript, but protein levels and functional analysis results were similar to the parental cell line. …”
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    Class III β-Tubulin Overexpression Induces Chemoresistance to Eribulin in a Leiomyosarcoma Cell Line
  5. 4125
    por LeBrun, Erick S., Kang, Sanghoon
    Publicado 2018
    “…The high homogeneity of microbial communities detected at each site allows sites to act as environmental replicates for comparing the two different functional analysis methods. We found that while both methods capture the homogeneity of the system, both differed greatly in the total abundance of genes detected, as well as the diversity of taxa detected. …”
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    A comparison of computationally predicted functional metagenomes and microarray analysis for microbial P cycle genes in a unique basalt-soil forest
  6. 4126
    “…SAM methods were leveraged to identify differentially expressed genes (DEGs). Functional analysis of DEGs was performed using DAVID. The GeneMania and Cytohubba were used to construct the PPI network. …”
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    Dysfunction of Sister Chromatids Separation Promotes Progression of Hepatocellular Carcinoma According to Analysis of Gene Expression Profiling
  7. 4127
    “…We have explored this hypothesis using mutagenesis and functional analysis, followed by molecular simulations. …”
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    The Insensitivity of TASK-3 K(2)P Channels to External Tetraethylammonium (TEA) Partially Depends on the Cap Structure
  8. 4128
    “…It often takes years before enough clinical data are acquired, and it can be costly and time‐consuming to perform functional analysis of a single variant. It is important that other tools are developed to aid in clarifying how a specific genetic variant impacts a protein's function, and ultimately the health of the patient. …”
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    Personalized molecular modeling for pinpointing associations of protein dysfunction and variants associated with hereditary cancer syndromes
  9. 4129
    “…In addition, it has been developed into a suitable host for the heterologous expression of natural product biosynthetic genes and gene clusters, enabling the functional analysis of the encoded enzymes. A. oryzae shares a 99.5% genome homology with Aspergillus flavus, but their secondary metabolomes differ significantly and various compounds unique to A. oryzae have been reported. …”
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    Oryzines A & B, Maleidride Congeners from Aspergillus oryzae and Their Putative Biosynthesis
  10. 4130
    “…The cell cycle distribution of Plac9 was analyzed by flow cytometry, and a functional analysis was performed using L02 cells following their stable infection with a lentivirus over-expressing Plac9. …”
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    Placenta-specific 9, a putative secretory protein, induces G2/M arrest and inhibits the proliferation of human embryonic hepatic cells
  11. 4131
    “…GRNs underlie almost all cellular phenomena; hence, comprehensive GRN maps are essential tools to elucidate gene function, thereby facilitating the identification and prioritization of candidate genes for functional analysis. High-throughput gene expression datasets have yielded various statistical and ML-based algorithms to infer causal relationship between genes and decipher GRNs. …”
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    Statistical and Machine Learning Approaches to Predict Gene Regulatory Networks From Transcriptome Datasets
  12. 4132
    “…Furthermore, lineage studies and functional analysis of Tbx1- and Pax3-null mice reveal a unique developmental program for somitic neck muscles that is distinct from that of somitic trunk muscles. …”
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    Unique morphogenetic signatures define mammalian neck muscles and associated connective tissues
  13. 4133
    por Beumann, Sarah, Wegner, Sven-Ake
    Publicado 2018
    “…RESULTS: We present results in the form of student feedback from a course on functional analysis for third- and fourth-year students. …”
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    An outlook on self-assessment of homework assignments in higher mathematics education
  14. 4134
    “…CRISPR/Cas9 has broad applications in basic research and biotechnology and has been widely used across eukaryotic species for genome engineering and functional analysis of genes. The recently developed CRISPR/Cas13 systems target RNA rather than DNA and thus offer new potential for transcriptome engineering and combatting RNA viruses. …”
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    Engineering RNA Virus Interference via the CRISPR/Cas13 Machinery in Arabidopsis
  15. 4135
    “…Our results showed that Dab1 was reduced in breast cancer, and its compromised expression correlated with triple negative breast cancer phenotype, poor differentiation, as well as lymph node metastasis. Functional analysis in breast cancer cell lines demonstrated that Dab1 promoted cell apoptosis, which, at least partially, depended on its regulation of NF‐κB/Bcl‐2/caspase‐9 pathway. …”
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    Disabled‐1 is down‐regulated in clinical breast cancer and regulates cell apoptosis through NF‐κB/Bcl‐2/caspase‐9
  16. 4136
    “…Phylotypic analysis showed that most viruses belonged to the order Caudovirales, especially the family Podoviridae (41.92–48.7%), which is similar to the situation in the Pacific Ocean. Functional analysis revealed a relatively high frequency of phage-associated and metabolism genes. …”
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    Metagenomic Characterization of the Viral Community of the South Scotia Ridge
  17. 4137
    “…Mesenchymal progenitor cells with a capacity to respond to titanium surface stimuli and differentiate into osteoblasts were used to perform comparative tests between two different implant topographies, including their functional interaction with pre-osteoblasts directly seeded onto the implants. Functional analysis of nanostructured implant surfaces was performed by in vitro assay analysis. …”
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    In Vitro Assessment of the Functional Dynamics of Titanium with Surface Coating of Hydroxyapatite Nanoparticles
  18. 4138
    “…We identified a novel splicing mutation (NM_006359.2:c.1141-8C>A) of SLC9A6 in a seven-year-old boy with microcephaly, severe developmental delay, and intractable epilepsy. Functional analysis found multiple aberrant transcripts, none of which maintained the canonical open reading frame. …”
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    A novel splicing mutation in SLC9A6 in a boy with Christianson syndrome
  19. 4139
    “…Thus, generations of zebrafish models utilize the functional analysis of genes involved in CAD, which are derived from large-scale human population analysis. …”
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    On Zebrafish Disease Models and Matters of the Heart
  20. 4140
    “…Microbial structure was significantly influenced by the treatment processes, shifting from Gammaproteobacteria and Betaproteobacteria in RW to Alphaproteobacteria in TW. Further functional analysis indicated the basic metabolic functions of microorganisms in TW did not vary considerably. …”
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    Metagenomic analysis reveals significant changes of microbial compositions and protective functions during drinking water treatment
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