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  1. 4301
    “…GSEA revealed that endothelial cells were enriched for upregulated IFN-g response genes when comparing treated cells to both untreated cells and cells treated after CD4(+) T cell depletion. Functional analysis showed that knocking out IFNgR1 in endothelial cells inhibited treatment response. …”
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    Endothelial cells are a key target of IFN-g during response to combined PD-1/CTLA-4 ICB treatment in a mouse model of bladder cancer
  2. 4302
    por Vargas Castro, A.
    Publicado 2023
    “…RESULTS: The results have been very positive and this is attributed to the transdisciplinary network around each patient, family inclusion and the multi-pronged psychotherapeutic approach based on functional analysis of every patient’s situation. CONCLUSIONS: In short, The Sun Project has shown that these approaches and interventions give excellent and rapid outcomes in pre-teens and adolescents suffering from suicide related thoughts and acts. …”
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    Suicidal crisis: A common cause of hospitalisation in adolescents. introducing an innovative program
  3. 4303
    “…Proteomics combined with lactic acid proteomics revealed 160 lysine lactylation (Kla) sites of 119 proteins. Functional analysis showed that the lactylation-modified proteins were enriched in the pathway of glucose and other substances’ metabolism, and many key enzymes of glycolysis and gluconeogenesis were lactated. …”
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    Protein Lactylation Modification and Proteomics Features in Cirrhosis Patients after UC-MSC Treatment
  4. 4304
    “…These results shed new light on the evolutionary trajectories of foxl2 and foxl2l and highlights the need for further detailed functional analysis of these two duplicated paralogs.…”
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    Comparative Studies on Duplicated foxl2 Paralogs in Spotted Knifejaw Oplegnathus punctatus Show Functional Diversification
  5. 4305
    “…The transcriptome sequencing analysis of wild-type (WT) and KO mice shows a large number of differentially expressed genes that are enriched in amino acid metabolism by functional analysis. Of note, glycine levels are substantially increased in the lungs of KO mice with or without P. multocida infection in comparison to the WT controls. …”
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    Slc6a13 Deficiency Attenuates Pasteurella multocida Infection-Induced Inflammation via Glycine-Inflammasome Signaling
  6. 4306
    “…Despite the advantage of high capture efficiency, downstream functional analysis of scRNA-seq data is made difficult by the excess of zero values (i.e., the dropout phenomenon). …”
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    Imputation method for single-cell RNA-seq data using neural topic model
  7. 4307
    “…We concentrate our functional analysis on global changes marking relevant pathways or functional groups of genes. …”
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    A Global Survey of Gene Regulation during Cold Acclimation in Arabidopsis thaliana
  8. 4308
    “…CONCLUSION: This method is able to spot structural similarities associated to function-related similarities, independently on sequence or fold resemblance, therefore is a valuable tool for the functional analysis of uncharacterized proteins. Results are available at…”
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    Functional annotation by identification of local surface similarities: a novel tool for structural genomics
  9. 4309
    “…This study includes characterization and functional analysis of p53 expressed in eight cell lines: three wild-type cell lines and five cell lines harboring mutations. …”
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    Expression of C-terminal deleted p53 isoforms in neuroblastoma
  10. 4310
    “…Our results open a new avenue for the annotation and functional analysis of genes and sequenced genomes, in which thousands of short ORFs are still uncharacterised.…”
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    Peptides Encoded by Short ORFs Control Development and Define a New Eukaryotic Gene Family
  11. 4311
    “…Our data further validate the effectiveness of antagomirs in vivo and should facilitate future studies to silence miRNAs for functional analysis and in clinically relevant settings.…”
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    Specificity, duplex degradation and subcellular localization of antagomirs
  12. 4312
    “…Crystal structures and their dynamic and functional analysis show entire loop grafts to be feasible, resulting in altered specificity, while individual point mutations do not change the nicking pattern of L1-EN. …”
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    Determinants for DNA target structure selectivity of the human LINE-1 retrotransposon endonuclease
  13. 4313
    “…One important aspect is the identification and functional analysis of regulatory elements in non-coding DNA. …”
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    Dissecting the action of an evolutionary conserved non-coding region on renin promoter activity
  14. 4314
    Publicado 1991
    “…Flow cytometry, immunoprecipitation, and mRNA analyses showed that cell activation with phorbol esters or with a variety of stimuli such as Staphylococcus aureus or anti-mu antibodies in combination with cytokines induced de novo CD11c/CD18 cell surface expression on most B cells while CD11b expression was not affected. Functional analysis of CD11c/CD18 on B cells revealed that it plays a dual role. …”
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    Regulated expression and function of CD11c/CD18 integrin on human B lymphocytes. Relation between attachment to fibrinogen and triggering of proliferation through CD11c/CD18
  15. 4315
    “…Here, we show that hCcr4, hDcp1b, hLsm, and rck/p54 proteins related to 5′–3′ mRNA decay also localize to these structures, whereas DcpS, which is involved in cap nucleotide catabolism, is nuclear. Functional analysis using fluorescence resonance energy transfer revealed that hDcp1a and hDcp2 interact in vivo in these structures that were shown to differ from the previously described stress granules. …”
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    Cytoplasmic foci are sites of mRNA decay in human cells
  16. 4316
    “…Large-scale proteomic and functional analysis of isolated pseudopodia revealed the Lim, actin, and SH3 domain protein (Lasp-1) as a novel protein necessary for cell migration, but not adhesion to, the extracellular matrix (ECM). …”
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    Regulation of cell migration and survival by focal adhesion targeting of Lasp-1
  17. 4317
    “…Structural and functional analysis of the heterogeneous heparinoids generally requires advanced equipment, is time consuming, and needs (extensive) sample preparation. …”
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    Characterization of anticoagulant heparinoids by immunoprofiling
  18. 4318
    “…Here, the genome sequence of Shewanella piezotolerans WP3, a piezotolerant and psychrotolerant iron reducing bacterium from deep-sea sediment was determined with related functional analysis to study its environmental adaptation mechanisms. …”
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    Environmental Adaptation: Genomic Analysis of the Piezotolerant and Psychrotolerant Deep-Sea Iron Reducing Bacterium Shewanella piezotolerans WP3
  19. 4319
    “…Mapping against genome sequences recovers additional 13% of EST data, which otherwise would escape further analysis. To enable functional analysis of the datasets, ESTs are functionally annotated using the hierarchical FunCat annotation scheme as well as GO annotation terms. …”
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    OREST: the online resource for EST analysis
  20. 4320
    “…Here, we describe a structural and functional analysis of the HR inhibitor protein RecX and its mode of interaction with the RecA filament. …”
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    Structural basis for inhibition of homologous recombination by the RecX protein
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