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  1. 4341
    por Li, Jade, Sun, Zhaoxia
    Publicado 2011
    “…In this paper we characterized qilin(hi3959A) mutant's phenotypes in detail, investigated cilia formation in this mutant and performed structural and functional analysis of the Qilin protein. Results reveal Qilin's essential role in cilia assembly and maintenance in multiple organs, including the kidney, the lateral line organ, and the outer segment of the photoreceptor cell. …”
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    Qilin Is Essential for Cilia Assembly and Normal Kidney Development in Zebrafish
  2. 4342
    “…Based on the data from the literature, extended functional analysis, including linkage disequilibrium analysis, pathway-based analysis and gene mapping were performed to provide new insights into genetic causes of ADHD. …”
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    ADHDgene: a genetic database for attention deficit hyperactivity disorder
  3. 4343
    “…RNAi-mediated knockdown of CTCF sharply diminished the interaction frequencies between the chromatin loops of the kcnq5 gene locus and down-regulated local gene expression. Functional analysis showed that the interacting chromatin loops of the kcnq5 gene locus can repress the gene expression in a luciferase reporter assay. …”
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    CTCF Mediates the Cell-Type Specific Spatial Organization of the Kcnq5 Locus and the Local Gene Regulation
  4. 4344
    por Zhou, Fengfeng, Ma, Qin, Li, Guojun, Xu, Ying
    Publicado 2012
    “…QServer supports the biclustering and functional analysis for a wide range of organisms, including human, mouse, Arabidopsis, bacteria and archaea, whose underlying genome database will be continuously updated. …”
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    QServer: A Biclustering Server for Prediction and Assessment of Co-Expressed Gene Clusters
  5. 4345
    “…To interrogate the phenotype of myeloid cells in vivo, we subjected elicited peritoneal macrophages harvested from wild-type and GM-CSF-deficient mice to mass spectrometric and functional analysis. Unexpectedly, we found that peritoneal macrophages exhibited many features of the DCs generated in vitro. …”
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    Unique Proteomic Signatures Distinguish Macrophages and Dendritic Cells
  6. 4346
    “…It provides several options including construction of taxonomic trees, creation of a composition chart, functional analysis using COGs, and comparative analysis of multiple metagenomic datasets. …”
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    Fast and Accurate Taxonomic Assignments of Metagenomic Sequences Using MetaBin
  7. 4347
    “…Here we aim to characterize the modes of binding between hT1R2–hT1R3 and low-molecular-weight sweet compounds by functional analysis of a series of site-directed mutants and by molecular modeling–based docking simulation at the binding pocket formed on the large extracellular amino-terminal domain (ATD) of hT1R2. …”
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    Characterization of the Modes of Binding between Human Sweet Taste Receptor and Low-Molecular-Weight Sweet Compounds
  8. 4348
    “…Several, but not all positions with higher impact showed evidence for purifying selection, or co-localized with known liver-associated transcription factor binding sites, demonstrating the value of empirical high-resolution functional analysis.…”
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    Massively parallel functional dissection of mammalian enhancers in vivo
  9. 4349
    “…Cell-free synthesis is an open and powerful tool for high-yield protein production in small reaction volumes predestined for high-throughput structural and functional analysis. Membrane proteins require addition of detergents for solubilization, liposomes, or nanodiscs. …”
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    Fluorescent In Situ Folding Control for Rapid Optimization of Cell-Free Membrane Protein Synthesis
  10. 4350
    “…BM transplant studies revealed that transplantation of NFAT5(+/−)ApoE(−/−) marrow into NFAT5(+/+)ApoE(−/−) mice resulted in a similar 86% reduction in lesion formation. In vitro functional analysis of BM-derived macrophages demonstrated that NFAT5 is required for macrophage migration, which is a key event in the propagation of atherosclerosis. …”
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    NFAT5 expression in bone marrow-derived cells enhances atherosclerosis and drives macrophage migration
  11. 4351
    “…Furthermore, the analysis supports that an IRAK4-like kinase is an ancestral protein in the metazoan lineage of the IRAK family. Through functional analysis, several potentially diverged sites were identified in the common death domain and kinase domain. …”
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    Molecular Evolution and Structural Features of IRAK Family Members
  12. 4352
    “…However, the methods for inference, functional analysis and visualization of gene regulatory modules and GRNs require the user to collect heterogeneous data from many sources using numerous bioinformatics tools. …”
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    An Integrative Approach to Inferring Gene Regulatory Module Networks
  13. 4353
    “…In the present study, we cloned a G protein-coupled receptor (GPCR) cDNA from the desert locust, Schistocerca gregaria. Cell-based functional analysis of this receptor indicated that it is activated by both known isoforms of Schgr-sNPF in a concentration dependent manner, with EC(50) values in the nanomolar range. …”
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    Functional Characterization of the Short Neuropeptide F Receptor in the Desert Locust, Schistocerca gregaria
  14. 4354
    “…Using the Illumina Infinium HumanMethylation27 BeadChip, we identified genes exhibiting differential methylation associated with normal labor and preterm birth. Functional analysis of the differentially methylated genes revealed biologically relevant enriched gene sets. …”
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    Genome-Wide Analysis of DNA Methylation in Human Amnion
  15. 4355
    por Krencik, Robert, Ullian, Erik M.
    Publicado 2013
    “…When designing experiments, careful consideration must be given to choosing paradigms for differentiation, maturation, and functional analysis of these temporally asynchronous cellular populations in culture. …”
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    A cellular star atlas: using astrocytes from human pluripotent stem cells for disease studies
  16. 4356
    por Zhang, Junran
    Publicado 2013
    “…Given the fact that DNA lesions caused by replication blockages are the primary substrates for HR in mitotic cells, functional analysis of BRCA1 in HR repair in the context of replication stress should benefit our understanding of the molecular mechanisms underlying tumorigenesis associated with BRCA1 deficiencies, as well as the development of therapeutic approaches for cancer patients carrying BRCA1 mutations or reduced BRCA1 expression. …”
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    The role of BRCA1 in homologous recombination repair in response to replication stress: significance in tumorigenesis and cancer therapy
  17. 4357
    “…Here we report the identification of a novel l-xylulose reductase LXR3 in the fungus Trichoderma reesei by a bioinformatic approach in combination with a functional analysis. LXR3, a 31 kDa protein, catalyzes the reduction of l-xylulose to xylitol via NADPH and is also able to convert d-xylulose, d-ribulose, l-sorbose, and d-fructose to their corresponding polyols. …”
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    A Novel l-Xylulose Reductase Essential for l-Arabinose Catabolism in Trichoderma reesei
  18. 4358
    “…Transwell cell migration and invasion assays were carried out for functional analysis. The effects of GABA on liver cancer cell cytoskeletal were determined by immunofluorescence staining. …”
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    Suppression of Human Liver Cancer Cell Migration and Invasion via the GABA(A) Receptor
  19. 4359
    “…The continuously increasing amount of RNA sequence and experimentally determined 3D structure data drives the development of computational methods supporting exploration of these data. Contemporary functional analysis of RNA molecules, such as ribozymes or riboswitches, covers various issues, among which tertiary structure modeling becomes more and more important. …”
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    RNAlyzer—novel approach for quality analysis of RNA structural models
  20. 4360
    “…Further studies including functional analysis of the detected mutations will provide precise information regarding the effect of the mutations. …”
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    Transient Neonatal Diabetes Mellitus in a Turkish Patient with Three Novel Homozygous Variants in the ZFP57 Gene
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