“…Collectively, our data bring new insights on Drosophila hemocyte function and open the route to post-genomic functional analysis of the cellular immune response.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A total of 58 ADCY FANGs were identified from the topologically associating domains on the basis of the Hi-C data. Functional analysis of these FANGs revealed abnormal activation of the MAPK signaling pathway. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A motif analysis and a gene functional analysis indicated the enrichment of RNA-binding protein (RBP) binding sites and neuronal functions for the set of genes with neuron-enhanced distal PAS usage. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here, we performed functional analysis of BmTCTP by using a binary transgenic CRISPR/Cas9 (clustered regularly interspaced short palindromic repeat/RNA‐guided CRISPER‐associated protein 9 nucleases) system. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Furthermore, we constructed an individualized prognosis prediction model through nomogram and time‐dependent receiver operating characteristic (ROC) curve analyses. Functional analysis suggested that, in addition to material and energy metabolism, ATP metabolism also played an essential role in the regulation of the tumor immune microenvironment. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Among RNA modifications, functional analysis of N(6)-methyladenosine (m(6)A), the most abundant RNA modification found from humans to plants is actively progressing, and it has also been known that m(6)A abnormality is involved in cancer and other diseases. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The P. brassicae and B. napus transcriptional patterns were modulated by these microbial diversities, these modulations being dependent on the host genotype plant and the kinetic time. The functional analysis of gene expressions allowed the identification of pathogen and plant host functions potentially involved in the change of plant disease level, such as pathogenicity‐related genes (NUDIX effector) in P. brassicae and plant defence‐related genes (glucosinolate metabolism) in B. napus.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Specific taxa that were significantly more abundant in PM-treated mice include Akkermansia muciniphila and several Bacteroides members. Predictive functional analysis revealed overrepresentation of carbohydrate metabolism function in the fecal microbiota of PM recipients compared to controls, and this function was linked to Bacteroides spp. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We also found that these genes were associated with poor overall survival and relapse free survival except CDCA7. The functional analysis showed that this gene family might take part in many processes, including cell division, apoptosis, DNA damage and DNA repair, which might contribute to the tumor progression. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In addition, high SNHG17 expression was associated with a poor prognosis in OC. Functional analysis revealed that SNHG17 could promote OC cell growth. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In combining structural and functional analysis, recent studies have begun to reveal how FLRT-mediated responses are precisely tuned – from forming different protein complexes to modulate either cell adhesion or repulsion in neurons. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, conventional reverse genetics cannot be applied for the functional analysis of genes that are essential during asexual blood-stage replication. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…It was soon followed by the documentation of the expression and functional analysis of transmembrane prostate androgen-induced protein (TMEPAI)/PMEPA1 in other solid tumors including renal, colon, breast, lung, and ovarian cancers. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Analysis of RNA-seq data from The Cancer Genome Atlas identified differentially expressed genes (DEGs) in EC (568 TTAGPs out of 3467) and ascertained DEGs associated with histological subtypes, higher grade endometrioid tumours and late stage EC. Functional analysis demonstrated that DEGs were predominantly involved in cell cycle regulation, while the survival analysis identified 69 DEGs associated with prognosis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Expression analyses of transcription and protein levels confirmed internal correlation and their relevance with the tumor. Functional analysis of these genes demonstrated their enrichment in pathways, including checkpoint, chromosomal region and protein serine/threonine kinase activity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The mRNA sequencing of AFB1-treated or OTA-treated chicken hepatocarcinoma and functional analysis revealed the pathways that were commonly regulated by both mycotoxins, especially PPAR signaling, focal adhesion, and MAPK signaling. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Quantitative PCR confirmed that CORT administration increased densities of Clostridium perfringens in the small intestine, but only HDC was associated with increased densities of the bacterium in ceca. Predictive functional analysis by Phylogenetic Investigation of Communities by Reconstruction of Unobserved States 2 (PICRUSt2) showed pathways of carbohydrate metabolism to be enriched with CORT, and amino acid synthesis to be enriched in control birds in the small intestine. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Begomoviruses appear to be internalized together with BtCubam via its interaction with the 12–19 CUB domains of BtCUBN via clathrin-dependent endocytosis. Functional analysis indicates that interruption of BtCUBN and BtAMN lead to reduction of virus acquisition and transmission by whitefly. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here, we carried out a comparative functional analysis of these transcription factors in wild-type and Aft plants, and tested their ability to take part in the transcriptional complexes that regulate the biosynthetic pathway and their efficiency in inducing anthocyanin pigmentation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Active compounds were selected using Oriental Medicine Advanced Searching Integrated System (OASIS) and the Traditional Chinese Medicine System Pharmacology Database and Analysis Platform (TCMSP), and target genes linked to the selected components were retrieved using Search Tool for Interacting Chemicals (STITCH) and GeneCards. Functional analysis of potential target genes was performed through the Annotation, Visualization and Integrated Discovery (DAVID) database and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, and molecular docking confirmed the correlation between five core compounds (quercetin, kaempferol, baicalein, ellagic acid, and baicalin) and six potential target genes (AKT1, CASP3, MAPK1, MAPK3, NOS2, and PTGS2). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso