“…Meanwhile, 45 cytosolic proteins were found to decrease in abundance. Functional analysis showed differential abundance proteins involved in the molecular function, biological process, and cellular component with 18.88%, 33.04% and, 48.07%, respectively. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our study characterized the phylogenetic relationship, gene structures and expression patterns of EgNF-YB gene family and investigated their potential roles in abiotic stress responses, which provides solid foundations for further functional analysis of NF-YB genes in eucalyptus.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The results provide a system-wide view of the entire M. persicae crotonylome and a rich data set for functional analysis of crotonylated proteins in this economically important pest, which marks an important beginning for the further research.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We found an enrichment of longevity‐associated genes in the nPKC and NF‐κB signaling pathways by gene‐based association analyses. Functional analysis of the top three gene variants (NFKBIA, CLU, PRKCH) suggests that non‐coding variants modulate the expression of cognate genes, thereby reducing signaling through the nPKC and NF‐κB. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…For this study, we performed bioinformatics and functional analysis of proteomic datasets, previously examined by our group, from samples of adolescents with regulated and unregulated type 1 diabetes, as they compare with healthy controls. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In mice, the LTβR is crucial for surviving acute toxoplasmosis; however, until now, a functional analysis was largely incomplete. Here, we demonstrate that the LTβR is a key regulator required for the intricate balance of adaptive immune responses. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To understand how synaptic composition changes in relation to neuropathology and cognition, multiplexed liquid chromatography mass-spectrometry was used to quantify enriched synaptic proteins from the parietal association cortex of 100 subjects with contrasting levels of AD pathology and cognitive performance. 123 unique proteins were significantly associated with diagnostic category. Functional analysis showed enrichment of serotonin release and oxidative phosphorylation categories in normal (cognitively unimpaired, low neuropathology) and “resilient” (unimpaired despite AD pathology) individuals. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Quantitative analysis revealed 478 and 344 significantly differentially expressed peptides (DEPs) in the acute and chronic infection stages, respectively. Functional analysis of DEPs by Gene Ontology suggested these DEPs mainly originated from cell part and took part in cellular process. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In particular, we report, for the first time, the expression patterns of MRP126, serglycin, TXNIP, and FZD2 during the pre-laying, egg-laying, and broody periods of goose ovaries. Functional analysis by GO annotation revealed that GO terms were mainly involved in actin, cell signal transduction and regulation, and cellular components. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Additional integration and functional analysis showed that genetic variants in these five gene regions are listed at a chromatin structure and state, predicting promoters, enhancers, DNase hypersensitivity and altered transcription factor binding sites. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The designed pipeline consists of three main steps: (1) sequencing, detection, and identification of genes/variants; (2) classification of variants according to their effect; and (3) variant characterization using in silico structural and functional analysis. The pipeline was validated through the analysis of the variants detected in a well-known PCD disease-causing gene (DNAI1) and the novel candidate gene (SPAG16). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Glycoproteomics, the study of glycans and their carrier proteins in a system-wide context, is becoming a powerful tool in glycobiology that enables the functional analysis of protein glycosylation. This ‘Hitchhiker's guide to glycoproteomics’ is intended as a starting point for anyone who wants to explore the emerging world of glycoproteomics. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We propose to use the Fourier basis function for transforming discrete weekly data to the smoothed functional ILI activities. Functional analysis of variance (FANOVA) is used to examine the regional differences in temporal patterns and the impact of state's political orientation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We identified 160 cellular proteins as interaction partners of the SARS-CoV-2 N protein in HEK293T and/or Calu-3 cells. Functional analysis revealed strong enrichment for ribosome biogenesis and RNA-associated processes, including ribonucleoprotein complex biogenesis, ribosomal large and small subunits biogenesis, RNA binding, catalysis, translation and transcription. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Whole exome analysis identified the homozygous mutation c.803dupT, p.Ser269llefs*35 in the SLC25A36 gene. Functional analysis of mutant SLC25A36 protein in proteoliposomes showed a virtually abolished transport activity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This is the first study of its kind which explores the distribution of archaeal PPIases, along with detailed structural and functional analysis of each type of PPIase found in archaea.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: Modular and functional analysis indicated that the organization of CLMN performed fundamental and specific functions in diabetes and DR pathology. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The obtained results correlate with the classification of sialoliths proposed by Tretiakow. The performed functional analysis allowed for the first time the selection of proteins, the levels of which differ between the tested samples, which may suggest the role of these proteins in the calcification process in different types of sialoliths. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A complementary approach for the functional analysis of a given gene is the examination of individuals harbouring a mutant allele of the gene. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Moreover, 80% of the upregulated genes are functionally related to abiotic and biotic stresses. Co-functional analysis of stress-responsive genes revealed a network of 18 genes that code for heat shock proteins, transcription factors (TFs), and calcium-binding proteins. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso