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  1. 4661
    “…We discuss the model stability using the Hyers-Ulam functional analysis. The numerical scheme for the Ebola-malaria coinfections using Lagrange interpolation is presented. …”
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    Fractional-Order Ebola-Malaria Coinfection Model with a Focus on Detection and Treatment Rate
  2. 4662
    “…Gene Ontology (GO) functional analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, and protein-protein interaction (PPI) network analysis were performed to elucidate molecular mechanisms of DEGs and screen hub genes. …”
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    Screening of Sepsis Biomarkers Based on Bioinformatics Data Analysis
  3. 4663
    “…Proteomics and bioinformatics were applied to determine the protein composition and complete the functional analysis of the EVs. Seventy-seven proteins were identified from Drynariae Rhizoma root-derived EVs, with enzymes accounting for 47% of the proteins. …”
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    Drug Value of Drynariae Rhizoma Root-Derived Extracellular Vesicles for Neurodegenerative Diseases Based on Proteomics and Bioinformatics
  4. 4664
    “…Notably, we found that Vegfa switches from the Vegfa 164 isoform to the longer Vegfa 188 isoform exclusively in lung alveolar epithelial AT1 cells. Functional analysis revealed that VEGFA 188 (and not VEGFA 164) drives the specification of Car4-positive aerocytes, a subtype of alveolar endothelial cells specialized in gas exchanges. …”
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    Aerocyte specification and lung adaptation to breathing is dependent on alternative splicing changes
  5. 4665
    por Naruse, Masae, Saito, Tetsuichiro
    Publicado 2022
    “…The delivery of exogenous mRNAs may be useful for not only vaccines but also functional analysis in the brain.…”
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    Immediate protein expression from exogenous mRNAs in embryonic brain
  6. 4666
    “…Moreover, the results also suggest that the functional analysis of the GSK3 family in stress responses can be a tool for plant breeding in order to improve crops’ resistance to salinity or to other stresses.…”
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    Inhibition of the Glycogen Synthase Kinase 3 Family by the Bikinin Alleviates the Long-Term Effects of Salinity in Barley
  7. 4667
    “…The MC interactome neighborhood of a protein encoded by a UC gene reverses the gene expression pattern. The functional analysis showed that the evolved environment of the UC proteins is typical for protein modifiers and signaling-related proteins. …”
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    Cellular Biogenetic Law and Its Distortion by Protein Interactions: A Possible Unified Framework for Cancer Biology and Regenerative Medicine
  8. 4668
    “…Objective: The aim of the present study was to explore the metabolic characteristics of patients with early-stage NAFLD based on the ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) technology, to identify differential metabolites and perform functional analysis, and especially, to establish a novel early NAFLD clinical diagnostic tool. …”
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    Serum metabolome alterations in patients with early nonalcoholic fatty liver disease
  9. 4669
    “…The in vivo approach allowed identification of 6, 9 and 42 new potential targets for Trx f, Trx m and NTRC, respectively, and an apparent specificity between NTRC and Trxs was achieved. Functional analysis showed that these targets are involved in several cellular processes.…”
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    New In Vivo Approach to Broaden the Thioredoxin Family Interactome in Chloroplasts
  10. 4670
    por Zhan, Xinqiao, Qian, Yichun, Mao, Bizeng
    Publicado 2022
    “…However, no identification or functional analysis of GELPs was reported in D. catenatum. …”
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    Identification of Two GDSL-Type Esterase/Lipase Genes Related to Tissue-Specific Lipolysis in Dendrobium catenatum by Multi-Omics Analysis
  11. 4671
    por Qiao, Han, Yin, Hong, Feng, Yan, Tang, Huaping
    Publicado 2022
    “…METHODS: Using TCGA, GEPIA, UALCAN, Kaplan-Meier plotters, Linkedomics, String, cBioPortal, TISIDB, TCIA and TIMER database methods, we investigated the expression of RCSD1 in human tumors and its relationship to clinical prognosis, functional analysis of co-expression networks, mutation status, and immune infiltration in cancers, especially lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). …”
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    Pan-cancer analysis reveals the relationship between RCSD1 immune infiltration and clinical prognosis in human tumors
  12. 4672
    “…Immune-related pathways were found in the functional analysis. Significant differences in enrichment scores for immune cells were observed. …”
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    Correlation between Ferroptosis-Related Gene Signature and Immune Landscape, Prognosis in Breast Cancer
  13. 4673
    “…RNA analysis revealed that this variant led to nonsense-mediated mRNA decay. In vitro functional analysis of the variant confirmed its role in increasing protein kinase A activity and cyclic adenosine monophosphate levels. …”
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    A Novel Missense PRKAR1A Variant Causes Carney Complex
  14. 4674
    “…Additionally, we performed a functional analysis of the lipids with significant differences using a recently developed database. …”
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    The lipidome of an omnivorous insect responds to diet composition and social environment
  15. 4675
    “…The results of functional analysis showed that the changes in these different microorganisms may affect the blood pressure of pregnant women by affecting the metabolism of vitamin K(2), sphingolipid, lipid acid and glycine. (4) Conclusion: Microbiota dysbiosis in PIH patients begins in the first trimester of pregnancy, and this may be associated with the occurrence of PIH. …”
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    The Association between Gut Microbiome and Pregnancy-Induced Hypertension: A Nested Case–Control Study
  16. 4676
    “…Methods: We performed analysis combining data on 7,875 somatic mutated genes with information on 1,751 immune-modulated genes, using gene-expression data as the intermediate phenotype, and correlated the resulting information with survival. We conducted functional analysis to identify immune-modulated molecular networks and signaling pathways enriched for somatic mutations likely to drive clinical outcomes. …”
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    Integrating Genomic Information with Tumor-Immune Microenvironment in Triple-Negative Breast Cancer
  17. 4677
    “…Herein, we report the synthesis and functional analysis of a novel nanoplatform in which a PEGylated MoS(2)-ZnO (MZ) nanocomposite was cloaked with a generally regarded as safe (GRAS)-grade Lactobacillus paracasei-derived extracellular vesicle (LPEV) for MZ-LPEV nanocomposite and evaluated its activity against Staphylococcus aureus. …”
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    A Nanocomposite with Extracellular Vesicles from Lactobacillus paracasei as a Bioinspired Nanoantibiotic Targeting Staphylococcus aureus
  18. 4678
    “…A transcriptome analysis of GBM cells exposed to G-1 was performed, followed by functional analysis of the differentially expressed genes. …”
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    Molecular Characterization of the Dual Effect of the GPER Agonist G-1 in Glioblastoma
  19. 4679
    “…RNA sequencing analysis showed that there are 1343, 48, and 1725 significantly differentially expressed genes (DEGs) in BMECs treated with NEFA, BHBA and their combination. GO functional analysis revealed that the DEGs were significantly enriched in “response to oxidative stress” and “inflammatory response”. …”
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    Transcriptome Analysis Reveals That NEFA and β-Hydroxybutyrate Induce Oxidative Stress and Inflammatory Response in Bovine Mammary Epithelial Cells
  20. 4680
    “…We found that piPSCs overexpressing OCT6 maintained colony morphology and pluripotency under differentiation conditions, with a similar gene expression pattern to that of non-differentiated piPSCs. Functional analysis revealed that OCT6 attenuated the adverse effects of extracellular signal-regulated kinase (ERK) signaling pathway inhibition on piPSC pluripotency by activating phosphatidylinositol 3-kinase-protein kinase B (PI3K-AKT) signaling activity. …”
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    OCT6 inhibits differentiation of porcine-induced pluripotent stem cells through MAPK and PI3K signaling regulation
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