“…We systematically tested the human LTR18A subfamily for regulatory activity using massively parallel reporter assay (MPRA) and found AP-1- and CEBP-related binding motifs as drivers of enhancer activity. Functional analysis of evolutionarily reconstructed ancestral sequences revealed that LTR18A elements have generally lost regulatory activity over time through sequence changes, with the largest effects occurring owing to mutations in the AP-1 and CEBP motifs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Genome analysis of a representative strain C2P003 resulted in a large number of unique gene sequences in comparison to other well-studied strains of the species. A functional analysis of the genome revealed features associated with the synthesis of exopolysaccharides, protein secretion and biofilm production as well as genes for stress adaptation, suggesting the ability of C2P003 to effectively colonize ash leaves. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Visual inspection is the traditional method behavior analysts use to interpret functional‐analysis results. Limitations of visual inspection include lack of standardized rules, subjectivity, and inconsistent interrater reliability (Fisch, 1998). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, for a time-efficient functional analysis of the coronaries, other methods must be applied.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here, we applied a structure-guided functional analysis of the bifunctional AE in the oncogenic human gammaherpesvirus Kaposi's sarcoma-associated herpesvirus (KSHV), called SOX. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…By testing this idea on bacterial pan-genome datasets, we showed that this approach was able to extract the most succinct feature sets that predicted AMR activities very well, indicating the potential of these genes as AMR biomarkers. The functional analysis demonstrated that the CVFS approach was able to extract both known AMR genes and novel ones, suggesting the capabilities of the algorithm in selecting relevant features and highlighting the potential of the novel genes in expanding the antimicrobial resistance gene databases.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These results pointed out the key FaMYBs for further functional analysis of gene regulation of strawberry fruit quality and would be helpful in the clarification on ofe roles of MYBs in the metabolism of fruit crops.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…With this morpho-functional analysis, we documented distinct microglia subpopulations eliciting sex-specific responses to stimulation: male microglia tended to have a more pro-inflammatory phenotype, while female microglia showed increased sensitivity to conduritol-B-epoxide (CBE), a small molecule inhibitor of glucocerebrosidase, the enzyme encoded by the GBA1 gene, mutations of which are the major risk factor for Parkinson’s Disease (PD). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Phylogenic analysis classified the genome of our strain close to the MP7 and LMG 24199 strains of P. vagans. Functional analysis showed that the highest number of genes within the analyzed bacterium genome were involved in transcription, amino acid transport and metabolism, and carbohydrate transport and metabolism. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: A total of 1796 DEGs were identified, including 1742 upregulated and 54 downregulated DEGs. A subsequent functional analysis showed that the significant DEGs were involved in the angiogenesis process. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Genes identified as differentially expressed were subjected to functional analysis with the Ingenuity Pathway Analysis software (IPA). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Oral administration of soybean sprouts grown for increased coumestrol (a HASPIN inhibitor) decreased the phosphorylated tau protein level in the hippocampus and suppressed short-term memory loss in the Alzheimer’s disease model mice (5xFAD). Functional analysis of HASPIN may help treatment of Alzheimer’s disease. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…(IBM Corp., Armonk, NY, USA), by a stepwise discriminant functional analysis for gender determination. Results Linear measurements, including maximum and minimum widths of the ramus, maximum height of the condyle, height of the ramus, and coronoid and bigonial width, revealed more values in males than in females. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Linear discriminant analysis Effect Size (LEfSe) analysis revealed that the populations of Actinomycetales including Nocardiaceae, Nocardia, Gordoniaceae, Gordonia, Nakamurellaceae, and Aeromonadaceae were reduced, whereas those of Rhizobiales including Xanthobacteraceae, Bradyrhizobiaceae, Rhodospirillaceae, and Pirellulaceae were increased in the gut microbiome. Functional analysis using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt2) predicted that P. sabiae administration altered taurine metabolism in the zebrafish gut, and we demonstrated that P. sabiae administration increased the taurine concentration in the brain. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Lions, and in particular the lower- and higher-order error estimates of asymptotic expansions are obtained in the setting of functional analysis. The review of differential geometry and treatment of boundary layers in a curved domain is an additional strength of this book. …”
Enlace del recurso
Enlace del recurso

“…The exploration of disease development and therapeutic strategies at the genetic level have become the key to the treatment of cancer and other genetic diseases. The functional analysis of genes and mutations has been slow and laborious. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Through further transcriptomics profiling and functional analysis, we discovered that neuronal HLH‐30/TFEB modulates neurotransmission through the hitherto uncharacterized protein W06A11.1 by inducing peripheral mitochondrial fragmentation and organismal heat stress resistance in a non‐cell autonomous manner. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Meanwhile, the differentially expressed genes (DEGs) between normal and tumor tissue were used to perform functional analysis, which showed a significant association with leukocyte transendothelial migration pathways in the TCGA cohort. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Differentially expressed genes (DEGs) and differentially methylated genes (DMGs) among the three groups (normal, NAFL, and NASH) were identified, and the functional analysis revealed that the development of NAFLD was primarily related to the oxidoreductase-related activity, PPAR signaling pathway, tight junction, and pathogenic Escherichia coli infection. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Proteomics analysis of the upper small intestine epithelial cells identified 3684 proteins, of which 1032 were differentially expressed proteins (DEPs). Functional analysis of DEPs showed significant enrichment of proteins related to endocytosis, protein transport, and tight junctions (TJ). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso